Journal ArticleDOI
Human milk: a source of more life than we imagine
Prescilla V. Jeurink,J. van Bergenhenegouwen,E. Jiménez,Léon M.J. Knippels,Leónides Fernández,Johan Garssen,Jan Knol,Juan M. Rodríguez,Rosario Martín +8 more
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TLDR
A better understanding of the link between the milk microbiome and health benefit, the potential factors influencing this relationship and whether or not it can be influenced by nutrition is required to open new avenues in the field of pregnancy and lactation.Abstract:
The presence of bacteria in human milk has been acknowledged since the seventies. For a long time, microbiological analysis of human milk was only performed in case of infections and therefore the presence of non-pathogenic bacteria was yet unknown. During the last decades, the use of more sophisticated culture-dependent and -independent techniques, and the steady development of the -omic approaches are opening up the new concept of the ‘milk microbiome’, a complex ecosystem with a greater diversity than previously anticipated. In this review, possible mechanisms by which bacteria can reach the mammary gland (contamination versus active migration) are discussed. In addition, the potential roles of human milk for both infant and maternal health are summarised. A better understanding of the link between the milk microbiome and health benefit, the potential factors influencing this relationship and whether or not it can be influenced by nutrition is required to open new avenues in the field of pregnancy and ...read more
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The microbiota of the respiratory tract: gatekeeper to respiratory health
Wing Ho Man,Wouter A. A. de Steenhuijsen Piters,Wouter A. A. de Steenhuijsen Piters,Debby Bogaert,Debby Bogaert +4 more
TL;DR: The epidemiological, biological and functional evidence that support the physiological role of the respiratory microbiota in the maintenance of human health are discussed.
Journal ArticleDOI
The infant microbiome development: mom matters
Noel T. Mueller,Elizabeth Bakacs,Joan Combellick,Zoya Grigoryan,Maria Gloria Dominguez-Bello +4 more
TL;DR: Recent knowledge about the impacts on infant microbiome assembly is reviewed, preventive and restorative strategies to ameliorate the effects of these impacts are discussed, and where research is needed to advance this field and improve the health of future generations are highlighted.
Journal ArticleDOI
Next-generation beneficial microbes : The case of Akkermansia muciniphila
TL;DR: It is proposed that microbes and microbiomegnosy, or knowledge of the authors' gut microbiome, can become a novel source of future therapies as plants and its related knowledge have been the source for designing drugs over the last century.
Journal ArticleDOI
Microbial Changes during Pregnancy, Birth, and Infancy.
TL;DR: The main factors shaping the infant microbiome—modes of delivery, feeding, weaning, and exposure to antibiotics are reviewed, starting to build a broader understanding of healthy vs. abnormal microbial alterations throughout major developmental time-points.
Journal ArticleDOI
Development of the gut microbiota in infancy and its impact on health in later life.
Masaru Tanaka,Jiro Nakayama +1 more
TL;DR: Recent findings regarding gut microbiota establishment are summarized, including the importance of various factors related to the development of the immune system and allergic diseases later in life are summarized.
References
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Gut microbiota in health and disease
TL;DR: The present article deals with the nomenclature, modern study techniques, and functions of gut microbiota, and its relation to health and disease.
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Characterization of the Diversity and Temporal Stability of Bacterial Communities in Human Milk
Katherine M Hunt,James A. Foster,Larry J. Forney,Ursel M. E. Schütte,Daniel Beck,Zaid Abdo,Lawrence K. Fox,Janet E. Williams,Michelle K. McGuire,Mark A. McGuire +9 more
TL;DR: The conclusion that human milk, which is recommended as the optimal nutrition source for almost all healthy infants, contains a collection of bacteria more diverse than previously reported is supported.
Journal ArticleDOI
Molecular analysis of human forearm superficial skin bacterial biota
TL;DR: The results show that the bacterial biota in normal superficial skin is highly diverse, with few well conserved and well represented genera, but otherwise low-level interpersonal consensus.
Journal ArticleDOI
Bacterial imprinting of the neonatal immune system: lessons from maternal cells?
Pablo Perez,Joël Doré,Marion Leclerc,Florence Levenez,Jalil Benyacoub,Patrick Serrant,Iris Segura-Roggero,Eduardo Schiffrin,Anne Donnet-Hughes +8 more
TL;DR: The results suggest that intestinally derived bacterial components are transported to the lactating breast within mononuclear cells, which programs the neonatal immune system to recognize specific bacterial molecular patterns and to respond appropriately to pathogens and commensal organisms.