Journal ArticleDOI
Human milk: a source of more life than we imagine
Prescilla V. Jeurink,J. van Bergenhenegouwen,E. Jiménez,Léon M.J. Knippels,Leónides Fernández,Johan Garssen,Jan Knol,Juan M. Rodríguez,Rosario Martín +8 more
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TLDR
A better understanding of the link between the milk microbiome and health benefit, the potential factors influencing this relationship and whether or not it can be influenced by nutrition is required to open new avenues in the field of pregnancy and lactation.Abstract:
The presence of bacteria in human milk has been acknowledged since the seventies. For a long time, microbiological analysis of human milk was only performed in case of infections and therefore the presence of non-pathogenic bacteria was yet unknown. During the last decades, the use of more sophisticated culture-dependent and -independent techniques, and the steady development of the -omic approaches are opening up the new concept of the ‘milk microbiome’, a complex ecosystem with a greater diversity than previously anticipated. In this review, possible mechanisms by which bacteria can reach the mammary gland (contamination versus active migration) are discussed. In addition, the potential roles of human milk for both infant and maternal health are summarised. A better understanding of the link between the milk microbiome and health benefit, the potential factors influencing this relationship and whether or not it can be influenced by nutrition is required to open new avenues in the field of pregnancy and ...read more
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The microbiota of the respiratory tract: gatekeeper to respiratory health
Wing Ho Man,Wouter A. A. de Steenhuijsen Piters,Wouter A. A. de Steenhuijsen Piters,Debby Bogaert,Debby Bogaert +4 more
TL;DR: The epidemiological, biological and functional evidence that support the physiological role of the respiratory microbiota in the maintenance of human health are discussed.
Journal ArticleDOI
The infant microbiome development: mom matters
Noel T. Mueller,Elizabeth Bakacs,Joan Combellick,Zoya Grigoryan,Maria Gloria Dominguez-Bello +4 more
TL;DR: Recent knowledge about the impacts on infant microbiome assembly is reviewed, preventive and restorative strategies to ameliorate the effects of these impacts are discussed, and where research is needed to advance this field and improve the health of future generations are highlighted.
Journal ArticleDOI
Next-generation beneficial microbes : The case of Akkermansia muciniphila
TL;DR: It is proposed that microbes and microbiomegnosy, or knowledge of the authors' gut microbiome, can become a novel source of future therapies as plants and its related knowledge have been the source for designing drugs over the last century.
Journal ArticleDOI
Microbial Changes during Pregnancy, Birth, and Infancy.
TL;DR: The main factors shaping the infant microbiome—modes of delivery, feeding, weaning, and exposure to antibiotics are reviewed, starting to build a broader understanding of healthy vs. abnormal microbial alterations throughout major developmental time-points.
Journal ArticleDOI
Development of the gut microbiota in infancy and its impact on health in later life.
Masaru Tanaka,Jiro Nakayama +1 more
TL;DR: Recent findings regarding gut microbiota establishment are summarized, including the importance of various factors related to the development of the immune system and allergic diseases later in life are summarized.
References
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TL;DR: It is suggested that breast milk polyamines improve the maturation of the rat intestinal and systemic immune system.
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miR-155 mediates suppressive effect of progesterone on TLR3, TLR4-triggered immune response
TL;DR: It is demonstrated that progesterone suppresses TLRs-triggered immune response by regulating miR-155, and the decreased mi R-155 contributes to inhibit TLR-induced IL-6 and IFN-β via increased SOCS1 expression.
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Inhibition of Human Immunodeficiency Virus Type 1 by Lactic Acid Bacteria from Human Breastmilk
TL;DR: It is demonstrated for the first time that commensal LAB from human breastmilk inhibit HIV-1 infection in vitro and a possible role for these bacteria in mucosal protection against HIV- 1 in the breastfeeding infant is suggested.
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Conquering common breast-feeding problems.
TL;DR: Avoiding conditions that cause pain, frustration, and anxiety can lead to premature weaning and avoidance of breast-feeding subsequent children.
Journal ArticleDOI
Molecular methods to measure intestinal bacteria: a review.
G Douglas Inglis Agriculture,Matthew C. Thomas,Dallas Thomas,Martin Kalmokoff,Stephen P. J. Brooks,L. Brent Selinger +5 more
TL;DR: In this article, the authors discuss methodologies used to monitor intestinal bacteria including: (i) traditional clone libraries; (ii) direct sequencing using next-generation parallel sequencing technology; (iii) denaturing gradient gel electrophoresis; (iv) terminal restriction fragment length polymorphism analysis; (v) fluorescent in situ hybridization; and quantitative PCR.