Journal ArticleDOI
Human rabies: neuropathogenesis, diagnosis, and management
Thiravat Hemachudha,Gabriella Ugolini,Supaporn Wacharapluesadee,Witaya Sungkarat,Shanop Shuangshoti,Jiraporn Laothamatas +5 more
TLDR
The shorter survival of patients with furious rabies compared with those with paralytic rabies closely corresponds to the greater amount of virus and lower immune response in the CNS of Patients with the furious form.Abstract:
Rabies is an almost invariably fatal disease that can present as classic furious rabies or paralytic rabies. Recovery has been reported in only a few patients, most of whom were infected with bat rabies virus variants, and has been associated with promptness of host immune response and spontaneous (immune) virus clearance. Viral mechanisms that have evolved to minimise damage to the CNS but enable the virus to spread might explain why survivors have overall good functional recovery. The shorter survival of patients with furious rabies compared with those with paralytic rabies closely corresponds to the greater amount of virus and lower immune response in the CNS of patients with the furious form. Rabies virus is present in the CNS long before symptom onset: subclinical anterior horn cell dysfunction and abnormal brain MRI in patients with furious rabies are evident days before brain symptoms develop. How the virus produces its devastating effects and how it selectively impairs behaviour in patients with furious rabies and the peripheral nerves of patients with paralytic rabies is beginning to be understood. However, to develop a pragmatic treatment strategy, a thorough understanding of the neuropathogenetic mechanisms is needed.read more
Citations
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Antibody response to rabies pre-exposure vaccination among village health volunteers in a northern region of Thailand
TL;DR: In this paper , the authors provide a pre-exposure prophylaxis rabies immunization to village health volunteers (VHV) who provide rabies vaccination for pets and free-roaming dogs in their villages and evaluate the antibody level and adverse effects after vaccination.
Journal ArticleDOI
Prevention and control of zoonoses at their source: from the Chinese perspective
TL;DR: A strategy that is suited to China's national conditions, is proposed, and the main factors contributing to the risk of zoonotic disease are analyzed.
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Roles of traditional medicine and traditional healers for rabies prevention and potential impacts on post-exposure prophylaxis: A literature review
TL;DR: Understanding the cultural context under which traditional remedies are used may facilitate collaboration of traditional healers with the modern medical system to ensure timely and appropriate use of proven therapies for prevention and clinical management of rabies.
Journal ArticleDOI
Potential of Immunotherapies in Treating Hematological Cancer-Infection Comorbidities-A Mathematical Modelling Approach.
TL;DR: In this article, a mechanism based computational model coupled a cancer-infection development to the adaptive immune system is presented and analyzed, and the model maps the outcome to the underlying physiological mechanisms and agree with numerous evidence-based medical observations.
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