Journal ArticleDOI
Human rabies: neuropathogenesis, diagnosis, and management
Thiravat Hemachudha,Gabriella Ugolini,Supaporn Wacharapluesadee,Witaya Sungkarat,Shanop Shuangshoti,Jiraporn Laothamatas +5 more
TLDR
The shorter survival of patients with furious rabies compared with those with paralytic rabies closely corresponds to the greater amount of virus and lower immune response in the CNS of Patients with the furious form.Abstract:
Rabies is an almost invariably fatal disease that can present as classic furious rabies or paralytic rabies. Recovery has been reported in only a few patients, most of whom were infected with bat rabies virus variants, and has been associated with promptness of host immune response and spontaneous (immune) virus clearance. Viral mechanisms that have evolved to minimise damage to the CNS but enable the virus to spread might explain why survivors have overall good functional recovery. The shorter survival of patients with furious rabies compared with those with paralytic rabies closely corresponds to the greater amount of virus and lower immune response in the CNS of patients with the furious form. Rabies virus is present in the CNS long before symptom onset: subclinical anterior horn cell dysfunction and abnormal brain MRI in patients with furious rabies are evident days before brain symptoms develop. How the virus produces its devastating effects and how it selectively impairs behaviour in patients with furious rabies and the peripheral nerves of patients with paralytic rabies is beginning to be understood. However, to develop a pragmatic treatment strategy, a thorough understanding of the neuropathogenetic mechanisms is needed.read more
Citations
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Book ChapterDOI
Neuromuscular Disorders in Tropical Areas
TL;DR: The main causes (infectious, toxic, nutritional, inflammatory, hereditary, etc.) of neuromuscular disorders occuring in tropical areas are summarized.
Book ChapterDOI
Rabies and the Lyssaviruses
Ashley C. Banyard,Ashley C. Banyard,Ashley C. Banyard,Anthony R. Fooks,Anthony R. Fooks,Anthony R. Fooks +5 more
TL;DR: A multifaceted approach that involves government support, disease awareness, vaccination of at-risk human populations and, most importantly, dog rabies control, is necessary to achieve the WHO goal of eliminating dog-mediated human rabies by 2030.
Journal ArticleDOI
Gene Expression Profile Induced by Two Different Variants of Street Rabies Virus in Mice
Camila Michele Appolinário,Janet M. Daly,Richard D. Emes,Fabio Albuquerque Marchi,Bruna Letícia Devidé Ribeiro,Jane Megid +5 more
TL;DR: The global gene expression in experimental infection due to V3 wild-type RABV, from the vampire bat Desmodus rotundus, an important source of infection for humans, domestic animals and wildlife in Latin America is demonstrated.
Posted ContentDOI
One-year descriptive analysis of patients treated at an anti-rabies clinic – a retrospective study from Kashmir
TL;DR: The burden of animal bites, especially dog bites, is huge in Kashmir and it is recommended that serious efforts directed towards immunizing and decreasing the stray dog population need to be put into practice to decrease the number of animal bite victims and prevent any rabies deaths.
Journal ArticleDOI
Redefining Non-Inferiority in Anamnestic Antibody Responses Using the Mean Increase of Log-Transformed Antibody Titers after Revaccination: Secondary Analysis of a Randomized Controlled Rabies Vaccination Trial.
Lisanne A Overduin,Patrick H P Soentjens,Jelle J. Goeman,Magdalena A Berkowska,Jacques J. M. van Dongen,Leo G. Visser +5 more
TL;DR: Comparing mean increases in log-transformed titers after revaccination appears to be a feasible and more informative method of studying non-inferiority regarding the anamnestic antibody response.
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