Hydrogen Sulfide Attenuates the Recruitment of CD11b+Gr-1+ Myeloid Cells and Regulates Bax/Bcl-2 Signaling in Myocardial Ischemia Injury
Youen Zhang,Hua Li,Gang Zhao,Aijun Sun,Nobel C. Zong,Zhaofeng Li,Hongming Zhu,Yunzeng Zou,Xiangdong Yang,Junbo Ge +9 more
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TLDR
The results demonstrated that the administration of NaHS improved survival, preserved left ventricular function, limited infarct size, and improved H2S levels in cardiac tissue to attenuate the recruitment of CD11b+Gr-1+ myeloid cells and to regulate the Bax/Bcl-2 pathway.Abstract:
Hydrogen sulfide, an endogenous signaling molecule, plays an important role in the physiology and pathophysiology of the cardiovascular system. Using a mouse model of myocardial infarction, we investigated the anti-inflammatory and anti-apoptotic effects of the H2S donor sodium hydrosulfide (NaHS). The results demonstrated that the administration of NaHS improved survival, preserved left ventricular function, limited infarct size, and improved H2S levels in cardiac tissue to attenuate the recruitment of CD11b(+)Gr-1(+) myeloid cells and to regulate the Bax/Bcl-2 pathway. Furthermore, the cardioprotective effects of NaHS were enhanced by inhibiting the migration of CD11b(+)Gr-1(+) myeloid cells from the spleen into the blood and by attenuating post-infarction inflammation. These observations suggest that the novel mechanism underlying the cardioprotective function of H2S is secondary to a combination of attenuation the recruitment of CD11b(+)Gr-1(+) myeloid cells and regulation of the Bax/Bcl-2 apoptotic signaling.read more
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The Role of Hydrogen Sulfide on Cardiovascular Homeostasis: An Overview with Update on Immunomodulation.
TL;DR: This review focuses on the recent progress on functional and mechanistic aspects of H2S in the inflammatory and immunoregulatory processes of cardiovascular disorders, importantly myocardial ischemia, heart failure, and atherosclerosis.
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Cardioprotection by H2S Donors: Nitric Oxide-Dependent and ‑Independent Mechanisms.
Athanasia Chatzianastasiou,Sofia Iris Bibli,Ioanna Andreadou,Panagiotis Efentakis,Nina Kaludercic,Mark E. Wood,Matthew Whiteman,Fabio Di Lisa,Andreas Daiber,Vangelis G. Manolopoulos,Csaba Szabó,D. Andreas Papapetropoulos +11 more
TL;DR: It is concluded that although all the H2S donors tested limited infarct size, the pathways involved were not conserved and cardioprotection exhibited by AP39 could result from a direct inhibitory effect on PTP acting at a site different than CypD.
Journal ArticleDOI
The role of mitochondrial reactive oxygen species, NO and H2S in ischaemia/reperfusion injury and cardioprotection
Ioanna Andreadou,Rainer Schulz,Andreas Papapetropoulos,Belma Turan,Kirsti Ytrehus,Péter Ferdinandy,Andreas Daiber,Fabio Di Lisa +7 more
TL;DR: The aim of the present review was to provide a critical analysis of formation and role of reactive species, NO and H2S in mitochondria, with a special emphasis on mechanisms of injury and protection that determine the fate of hearts subjected to I/R.
Journal ArticleDOI
Physiological roles of hydrogen sulfide in mammalian cells, tissues and organs.
TL;DR: A wide array of significant roles of H2S in the physiological regulation of all organ functions emerges from this review.
Journal ArticleDOI
GYY4137 attenuates remodeling, preserves cardiac function and modulates the natriuretic peptide response to ischemia
Shera Lilyanna,Shera Lilyanna,Meng Teng Peh,Oi Wah Liew,Oi Wah Liew,Peipei Wang,Peipei Wang,Philip K. Moore,Arthur Mark Richards,Eliana C. Martinez,Eliana C. Martinez +10 more
TL;DR: The data suggest that the slow-releasing H2S donor, GYY4137, preserves cardiac function, attenuates adverse remodeling and may exert post-ischemic cardioprotective effects in part through enhanced early post-ISChemic endogenous natriuretic peptide activation.
References
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Two’s company, three’s a crowd: can H2S be the third endogenous gaseous transmitter?
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Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction
Christophe Piot,Pierre Croisille,P. Staat,Hélène Thibault,Gilles Rioufol,Nathan Mewton,Rachid Elbelghiti,Thien Tri Cung,Eric Bonnefoy,Denis Angoulvant,Christophe Macia,Franck Raczka,Catherine Sportouch,Gérald Gahide,Gérard Finet,Xavier André-Fouët,Didier Revel,Gilbert Kirkorian,Jean-Pierre Monassier,Geneviève Derumeaux,Michel Ovize +20 more
TL;DR: Administration of cyclosporine at the time of reperfusion was associated with a smaller infarct by some measures than that seen with placebo, and these data are preliminary and require confirmation in a larger clinical trial.
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Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
John W. Elrod,John W. Calvert,Joanna Morrison,Jeannette E. Doeller,David W. Kraus,Ling Tao,Xiangying Jiao,Rosario Scalia,Levente Kiss,Csaba Szabó,Hideo Kimura,Chi Wing Chow,David J. Lefer +12 more
TL;DR: It is demonstrated that the delivery of H2S at the time of reperfusion limits infarct size and preserves left ventricular (LV) function in an in vivo model of myocardial ischemia-reperfusion (MI-R) and that either administration of H 2S or the modulation of endogenous production may be of clinical benefit in ischemic disorders.
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Regulation of the Inflammatory Response in Cardiac Repair
TL;DR: Understanding of inhibitory and proresolving signals in the infarcted heart and identification of patients with uncontrolled postinfarction inflammation and defective cardiac repair is needed to design novel therapeutic strategies.