Journal ArticleDOI
IL-6 Induced M1 Type Macrophage Polarization Increases Radiosensitivity in HPV Positive Head and Neck Cancer
Xiaohang Chen,Enhui Fu,Huihuang Lou,Xionghui Mao,Bingqing Yan,Fangjia Tong,Ji Sun,Lanlan Wei +7 more
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TLDR
M1 macrophages represent an important tissue microenvironment factor with implications for HNSC treatment efficacy and may prove valuable as a biomarker of radiation sensitivity.About:
This article is published in Cancer Letters.The article was published on 2019-08-01. It has received 36 citations till now. The article focuses on the topics: Macrophage polarization & Radiosensitivity.read more
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Polarization of tumor-associated macrophages by TLR7/8 conjugated radiosensitive peptide hydrogel for overcoming tumor radioresistance
Fumin Zhang,Zujian Feng,Jinjian Liu,Hui Li,Qi Su,Jiamin Zhang,Pingsheng Huang,Weiwei Wang,Jianfeng Liu +8 more
TL;DR: Wang et al. as mentioned in this paper showed that TAMs repolarization regulated by Smac-TLR7/8 hydrogel could increase tumor necrosis factor secretion, activate antitumor immune response and effectively inhibit tumor growth.
Journal ArticleDOI
Patterns of Immune Infiltration in HNC and Their Clinical Implications: A Gene Expression-Based Study
TL;DR: A difference in immune response may be an important driver of head and neck cancer progression and response to treatment and the deconvolution algorithm of gene expression microarray data by CIBERSOFT provides useful information about the immune cell composition of HNC patients.
Journal ArticleDOI
Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer: Focus on Immunological Aspects.
TL;DR: The reported cellular and immunological factors involved in the enhanced radiation response in HPV-driven head and neck squamous cell carcinomas are discussed, focusing on the vital role of the immune response in the outcome of HNSCC radiotherapy.
Journal ArticleDOI
Radiation-Induced Immunity and Toxicities: The Versatility of the cGAS-STING Pathway
TL;DR: In this article, the authors reviewed how radiation therapy can modulate the immune response involved in the tumor control and side effects associated with inflammatory processes and discussed the versatile roles of tumor microenvironment components during RT, how the innate immune sensing of RT-induced genotoxicity, through the cGAS-STING pathway, might link the anti-tumor immune response, radiationinduced necrosis and radiation-induced fibrosis.
Journal ArticleDOI
Interplay between cancer cells and M2 macrophages is necessary for miR-550a-3-5p down-regulation-mediated HPV-positive OSCC progression
Ming-xin Cao,Wei-long Zhang,Xiang-hua Yu,Jia-Shun Wu,Xin-Wei Qiao,Mei-Chang Huang,Ke Wang,Jing-biao Wu,Ya-Jie Tang,Jian Jiang,Xin-hua Liang,Ya-ling Tang +11 more
TL;DR: It is found that miR-550a-3-5p suppressed the migration, invasion and EMT of HPV- positive OSCC cells dependent on decreasing M2 macrophages polarization, revealing a novel crosstalk between cancer cells and immune cells in HPV-positive OSCC microenvironment.
References
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Journal ArticleDOI
Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
Peter J. Murray,Judith E. Allen,Subhra K. Biswas,Edward A. Fisher,Derek W. Gilroy,Sergij Goerdt,Siamon Gordon,John A. Hamilton,Lionel B. Ivashkiv,Toby Lawrence,Massimo Locati,Alberto Mantovani,Fernando O. Martinez,Jean-Louis Mege,David M. Mosser,Gioacchino Natoli,Jeroen P. J. Saeij,Joachim L. Schultze,Kari Ann Shirey,Antonio Sica,Jill Suttles,Irina A. Udalova,Jo A. Van Ginderachter,Stefanie N. Vogel,Thomas A. Wynn +24 more
TL;DR: A set of standards encompassing three principles-the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation are described with the goal of unifying experimental standards for diverse experimental scenarios.
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Human Papillomaviruses; Epithelial Tropisms, and the Development of Neoplasia
TL;DR: It appears that cellular environment and the site of infection affect viral pathogenicity by modulating viral gene expression, and changes in E6 and E7 expression are thought to account for the development of neoplasias at the endocervix, the anal and cervical transformation zones, and the tonsilar crypts and other oropharyngeal sites.
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SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation
Hongwei Qin,Andrew T. Holdbrooks,Yudong Liu,Stephanie L. Reynolds,Lora L. Yanagisawa,Etty N. Benveniste +5 more
TL;DR: Findings collectively indicate that SOCS3 is involved in repressing the M1 proinflammatory phenotype, thereby deactivating inflammatory responses in macrophages.
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Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage
Irina Ushach,Albert Zlotnik +1 more
TL;DR: It is intriguing to consider how evolution has directed these pathways to develop; their complexity likely mirrors the multiple functions in which cells of the monocyte/macrophage system are involved.
Journal ArticleDOI
Opposite Effects of M1 and M2 Macrophage Subtypes on Lung Cancer Progression
Ang Yuan,Yi-Jing Hsiao,Hsuan-Yu Chen,Huei-Wen Chen,Chao-Chi Ho,Yu-Yun Chen,Yi-Chia Liu,Tsai-Hsia Hong,Tsai-Hsia Hong,Sung-Liang Yu,Jeremy J.W. Chen,Pan-Chyr Yang +11 more
TL;DR: The results suggest that M1/M2 gene expression signature may be used as a prognostic indicator for lung cancer patients, and M1- and M2-polarized subtypes may be a target of investigation of immune-modulating therapies for Lung cancer in the future.