Journal ArticleDOI
Chemokines: multiple levels of leukocyte migration control☆ ☆
TLDR
New insights into the role of chemokines in leukocytes attraction and relocation will be discussed, with emphasis on the distinct levels of leukocyte migration control that ultimately determine the performance of the immune defense system.About:
This article is published in Trends in Immunology.The article was published on 2004-02-01. It has received 849 citations till now. The article focuses on the topics: Leukocyte migration.read more
Citations
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Journal ArticleDOI
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.
Beili Wu,Ellen Y.T. Chien,Clifford D. Mol,Gustavo Fenalti,Wei Liu,Vsevolod Katritch,Ruben Abagyan,Alexei Brooun,Peter A. Wells,F. Christopher Bi,Damon J. Hamel,Peter Kuhn,Tracy M. Handel,Vadim Cherezov,Raymond C. Stevens +14 more
TL;DR: Five independent crystal structures of CXCR4 bound to an antagonist small molecule IT1t and a cyclic peptide CVX15 at 2.5 to 3.2 angstrom resolution reveal a consistent homodimer with an interface including helices V and VI that may be involved in regulating signaling.
Journal ArticleDOI
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
TL;DR: This review will focus on the role of the main cytokines, chemokines, and their receptors in the pathophysiology of auto-inflammatory disorders, pro- inflammatory disorders, and neurological disorders involving inflammation.
Journal ArticleDOI
Targeting proteases: successes, failures and future prospects.
TL;DR: The status of human protease research and prospects for future protease-targeted drugs are reviewed, with reference to some key examples where protease drugs have succeeded or failed.
Journal ArticleDOI
The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes.
Karl Balabanian,Bernard Lagane,Simona Infantino,Ken Y.C. Chow,Julie Harriague,Barbara Moepps,Fernando Arenzana-Seisdedos,Marcus Thelen,Françoise Bachelerie +8 more
TL;DR: It is demonstrated that RDC1 is expressed in T lymphocytes and that CXCL12-promoted chemotaxis is inhibited by an anti-RDC1 monoclonal antibody, and it is shown that CxCL12, the only known natural ligand for CXCR4, binds to and signals through R DC1.
Journal ArticleDOI
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
Virginia Pascual,Virginia Pascual,Florence Allantaz,Edsel Arce,Marilynn Punaro,Marilynn Punaro,Jacques Banchereau +6 more
TL;DR: It is shown that serum from SoJIA patients induces the transcription of innate immunity genes, including interleukin (IL)-1 in healthy peripheral blood mononuclear cells (PBMCs), and that this cytokine represents a target for therapy in this disease.
References
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Journal ArticleDOI
International Union of Pharmacology: Approaches to the Nomenclature of Voltage-Gated Ion Channels
William A. Catterall,K. G. Chandy,David E. Clapham,George A. Gutman,Franz Hofmann,Anthony J. Harmar,Darrell R. Abernethy,Michael Spedding +7 more
TL;DR: This issue of Pharmacological Reviews includes a new venture in the collaboration between the International Union of Pharmacology (IUPHAR) and the American Society for Pharmacology and Experimental Therapeutics (ASPET), in that a new classification of voltage-gated ion channels is outlined.
Journal ArticleDOI
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TL;DR: It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM).
Journal ArticleDOI
Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
Journal ArticleDOI
Chemokines: A New Classification System and Their Role in Immunity
Albert Zlotnik,Osamu Yoshie +1 more
Journal ArticleDOI
Mouse and human dendritic cell subtypes
Ken Shortman,Yong-Jun Liu +1 more
TL;DR: The dynamics of the DC network in response to microbial invasion is studied, because many DC subtypes arise from separate developmental pathways, and their development and function are modulated by exogenous factors.
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