Improved Noninvasive prediction of Liver Fibrosis by Liver Stiffness Measurement in Patients with Nonalcoholic Fatty Liver Disease Accounting for Controlled Attenuation Parameter Values
Salvatore Petta,Vincent Wai-Sun Wong,Calogero Cammà,Jean-Baptiste Hiriart,Grace Lai-Hung Wong,Fabio Marra,Julien Vergniol,Anthony W.H. Chan,Vito Di Marco,Wassil Merrouche,Henry Lik-Yuen Chan,Marco Barbara,Brigitte Le-Bail,Umberto Arena,Antonio Craxì,Victor de Ledinghen +15 more
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TLDR
In patients with NAFLD, CAP values should always be taken into account in order to avoid overestimations of liver fibrosis assessed by transient elastography.About:
This article is published in Hepatology.The article was published on 2017-04-01 and is currently open access. It has received 168 citations till now. The article focuses on the topics: Nonalcoholic fatty liver disease.read more
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Criteria to Determine Reliability of Noninvasive Assessment of Liver Fibrosis With Virtual Touch Quantification.
Jérôme Boursier,Christophe Cassinotto,Gilles Hunault,Sarah Shili,Jérôme Lebigot,Bruno Lapuyade,Adrien Lannes,Jean-Baptiste Hiriart,V. Cartier,Brigitte Le Bail,Sophie Michalak,Amaury Mouries,Frédéric Oberti,Faiza Chermak,Isabelle Fouchard-Hubert,Paul Calès,Christophe Aubé,Victor de Ledinghen +17 more
TL;DR: The reliability criteria for liver fibrosis assessment with VTQ will help physicians to accurately evaluate the severity of chronic liver diseases and monitor their progression and was shown to influence the diagnostic accuracy.
Journal ArticleDOI
Non-invasive assessment of non-alcoholic fatty liver disease: ultrasound and transient elastography.
TL;DR: The rational basis for the use of ultrasound and transient elastography in patients with NAFLD is reviewed and an overview of newer sonographic applications that might be used in clinical practice in the near future in this field is given.
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Controversies and Opportunities in the Use of Inflammatory Markers for Diagnosis or Risk Prediction in Fatty Liver Disease.
Joeri Lambrecht,Frank Tacke +1 more
TL;DR: In this article, the authors discuss the utility of such novel inflammatory markers for non-alcoholic fatty liver disease (NAFLD) diagnosis, patient stratification and risk prediction, including cytokines, chemokines or shed receptors from immune cells, circulating exosomes related to inflammation, and changing proportions of peripheral blood mononuclear cell (PBMC) subtypes.
Journal ArticleDOI
How histopathologic changes in pediatric nonalcoholic fatty liver disease influence in vivo liver stiffness
Christian A. Hudert,Heiko Tzschätzsch,Birgit Rudolph,Christoph Loddenkemper,Hermann-Georg Holzhütter,Laura Kalveram,Susanna Wiegand,Jürgen Braun,Ingolf Sack,Jing Guo +9 more
TL;DR: In this paper, the influence of seven distinct histopathologic features on LS, including septal infiltration, bridging fibrosis, pericellular fibrosis and hepatocellular ballooning, portal inflammation, lobular inflammation, and steatosis was analyzed.
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Using controlled attenuation parameter combined with ultrasound to survey non-alcoholic fatty liver disease in hemodialysis patients: A prospective cohort study
Yi-Hao Yen,Jin-Bor Chen,Ben-Chung Cheng,Jung-Fu Chen,Kuo-Chin Chang,Po-Lin Tseng,Cheng-Kun Wu,Ming-Chao Tsai,Ming-Tsung Lin,Tsung-Hui Hu +9 more
TL;DR: The number of diagnoses of NAFLD made by using CAP combined with ultrasound was more than 2 times the number made with ultrasound alone in the hemodialysis patients.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes
Zobair M. Younossi,Zobair M. Younossi,Aaron B. Koenig,Dinan Abdelatif,Yousef Fazel,Linda Henry,Mark Wymer,Mark Wymer +7 more
TL;DR: As the global epidemic of obesity fuels metabolic conditions, the clinical and economic burden of NAFLD will become enormous, and random‐effects models were used to provide point estimates of prevalence, incidence, mortality and incidence rate ratios.
Journal ArticleDOI
EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease
Giulio Marchesini,Christopher P. Day,Jean-François Dufour,Ali Canbay,Valerio Nobili,Vlad Ratziu,Herbert Tilg,Michael Roden,Amalia Gastaldelli,Hannele Yki-Järvinen,Fritz Schick,Roberto Vettor,Gema Frühbeck,Lisbeth Mathus-Vliegen +13 more
TL;DR: The final purpose is to improve patient care and awareness of the importance of NAFLD, and to assist stakeholders in the decision-making process by providing evidence-based data, which also takes into consideration the burden of clinical management for the healthcare system.
Journal ArticleDOI
The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD
Paul Angulo,Jason M. Hui,Giulio Marchesini,Ellisabetta Bugianesi,Jacob George,Geoffrey C. Farrell,Felicity Enders,Sushma Saksena,Alastair D. Burt,John P. Bida,Keith D. Lindor,Schuyler O. Sanderson,Marco Lenzi,Leon A. Adams,James G. Kench,Terry M. Therneau,Christopher P. Day +16 more
TL;DR: A simple scoring system accurately separates patients with nonalcoholic fatty liver disease with and without advanced fibrosis, rendering liver biopsy for identification ofAdvanced fibrosis unnecessary in a substantial proportion of patients.
Journal ArticleDOI
Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease
Paul Angulo,David E. Kleiner,Sanne Dam-Larsen,Leon A. Adams,Einar Björnsson,Phunchai Charatcharoenwitthaya,Peter R. Mills,Jill C. Keach,Heather D. Lafferty,Alisha C. Stahler,Svanhildur Haflidadottir,Flemming Bendtsen +11 more
TL;DR: In a longitudinal study of patients with NAFLD, fibrosis stage, but no other histologic features of steatohepatitis, were associated independently with long-term overall mortality, liver transplantation, and liver-related events.