Improved Noninvasive prediction of Liver Fibrosis by Liver Stiffness Measurement in Patients with Nonalcoholic Fatty Liver Disease Accounting for Controlled Attenuation Parameter Values
Salvatore Petta,Vincent Wai-Sun Wong,Calogero Cammà,Jean-Baptiste Hiriart,Grace Lai-Hung Wong,Fabio Marra,Julien Vergniol,Anthony W.H. Chan,Vito Di Marco,Wassil Merrouche,Henry Lik-Yuen Chan,Marco Barbara,Brigitte Le-Bail,Umberto Arena,Antonio Craxì,Victor de Ledinghen +15 more
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TLDR
In patients with NAFLD, CAP values should always be taken into account in order to avoid overestimations of liver fibrosis assessed by transient elastography.About:
This article is published in Hepatology.The article was published on 2017-04-01 and is currently open access. It has received 168 citations till now. The article focuses on the topics: Nonalcoholic fatty liver disease.read more
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Journal ArticleDOI
Association Between Hepatic Steatosis, Measured by Controlled Attenuation Parameter, and Fibrosis Burden in Chronic Hepatitis B
Wai-Kay Seto,Rex Wh Hui,Lung-Yi Mak,James Fung,Ka Shing Cheung,Kevin Liu,Danny Ka-Ho Wong,Ching-Lung Lai,Man-Fung Yuen +8 more
TL;DR: Severe steatosis, determined by CAP measurement, is associated with severe fibrosis in treatment‐naïve patients with CHB and in patients receiving treatment.
Journal ArticleDOI
Role of imaging-based biomarkers in NAFLD: Recent advances in clinical application and future research directions.
TL;DR: The different non-invasive imaging modalities available to quantify liver fat and liver fibrosis and the limitations of current modalities to detect the progressive form for NAFLD, termed non-alcoholic steatohepatitis are discussed.
Journal ArticleDOI
Controlled Attenuation Parameter And Alcoholic Hepatic Steatosis: Diagnostic Accuracy and Role Of Alcohol Detoxification
Maja Thiele,Vanessa Rausch,Gabriele Fluhr,Maria Kjærgaard,Felix Piecha,Johannes Mueller,Beate K. Straub,Beate K. Straub,Monica Lupsor-Platon,Victor De-Ledinghen,Helmut K. Seitz,Sönke Detlefsen,Bjørn Stæhr Madsen,Aleksander Krag,Sebastian Mueller +14 more
TL;DR: It is shown that CAP highly correlates with liver fat, and patients with a CAP value above 290 dB/m were highly likely to have more than 5% fat in their livers, determined by liver biopsy, and three in four (non-obese) patients rapidly decrease in CAP after short-term alcohol withdrawal.
Journal ArticleDOI
Hepatic steatosis progresses faster in HIV mono-infected than HIV/HCV co-infected patients and is associated with liver fibrosis.
Tom Pembroke,Marc Deschenes,Bertrand Lebouché,Amine Benmassaoud,Maida J. Sewitch,Peter Ghali,Philip Wong,Alex S Halme,Elise Vuille-Lessard,Costa Pexos,Marina B. Klein,Giada Sebastiani +11 more
TL;DR: HS progresses faster and is associated with liver fibrosis progression in HIV mono-infection but not in HIV/HCV co- Infection, and it is found that HIV+ patients without HCV co,infection develop fatty liver more frequently than those co-infected with HCV.
Journal ArticleDOI
Monitoring Occurrence of Liver-Related Events and Survival by Transient Elastography in Patients With Nonalcoholic Fatty Liver Disease and Compensated Advanced Chronic Liver Disease.
Salvatore Petta,Giada Sebastiani,Mauro Viganò,Javier Ampuero,Vincent Wai-Sun Wong,Jérôme Boursier,Annalisa Berzigotti,Elisabetta Bugianesi,Anna Ludovica Fracanzani,Calogero Cammà,Marco Enea,Marraud des Grottes,Vito Di Marco,Ramy Younes,Aline Keyrouz,Sergio Mazzola,Yuly P. Mendoza,Grazia Pennisi,Manuel Romero-Gómez,Antonio Craxì,Victor de Ledinghen +20 more
TL;DR: In patients with NAFLD and compensated advanced chronic liver disease, baseline LSM and change in LSM are associated with risk of liver-related events and mortality.
References
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Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes
Zobair M. Younossi,Zobair M. Younossi,Aaron B. Koenig,Dinan Abdelatif,Yousef Fazel,Linda Henry,Mark Wymer,Mark Wymer +7 more
TL;DR: As the global epidemic of obesity fuels metabolic conditions, the clinical and economic burden of NAFLD will become enormous, and random‐effects models were used to provide point estimates of prevalence, incidence, mortality and incidence rate ratios.
Journal ArticleDOI
EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease
Giulio Marchesini,Christopher P. Day,Jean-François Dufour,Ali Canbay,Valerio Nobili,Vlad Ratziu,Herbert Tilg,Michael Roden,Amalia Gastaldelli,Hannele Yki-Järvinen,Fritz Schick,Roberto Vettor,Gema Frühbeck,Lisbeth Mathus-Vliegen +13 more
TL;DR: The final purpose is to improve patient care and awareness of the importance of NAFLD, and to assist stakeholders in the decision-making process by providing evidence-based data, which also takes into consideration the burden of clinical management for the healthcare system.
Journal ArticleDOI
The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD
Paul Angulo,Jason M. Hui,Giulio Marchesini,Ellisabetta Bugianesi,Jacob George,Geoffrey C. Farrell,Felicity Enders,Sushma Saksena,Alastair D. Burt,John P. Bida,Keith D. Lindor,Schuyler O. Sanderson,Marco Lenzi,Leon A. Adams,James G. Kench,Terry M. Therneau,Christopher P. Day +16 more
TL;DR: A simple scoring system accurately separates patients with nonalcoholic fatty liver disease with and without advanced fibrosis, rendering liver biopsy for identification ofAdvanced fibrosis unnecessary in a substantial proportion of patients.
Journal ArticleDOI
Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease
Paul Angulo,David E. Kleiner,Sanne Dam-Larsen,Leon A. Adams,Einar Björnsson,Phunchai Charatcharoenwitthaya,Peter R. Mills,Jill C. Keach,Heather D. Lafferty,Alisha C. Stahler,Svanhildur Haflidadottir,Flemming Bendtsen +11 more
TL;DR: In a longitudinal study of patients with NAFLD, fibrosis stage, but no other histologic features of steatohepatitis, were associated independently with long-term overall mortality, liver transplantation, and liver-related events.