Improved Noninvasive prediction of Liver Fibrosis by Liver Stiffness Measurement in Patients with Nonalcoholic Fatty Liver Disease Accounting for Controlled Attenuation Parameter Values
Salvatore Petta,Vincent Wai-Sun Wong,Calogero Cammà,Jean-Baptiste Hiriart,Grace Lai-Hung Wong,Fabio Marra,Julien Vergniol,Anthony W.H. Chan,Vito Di Marco,Wassil Merrouche,Henry Lik-Yuen Chan,Marco Barbara,Brigitte Le-Bail,Umberto Arena,Antonio Craxì,Victor de Ledinghen +15 more
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TLDR
In patients with NAFLD, CAP values should always be taken into account in order to avoid overestimations of liver fibrosis assessed by transient elastography.About:
This article is published in Hepatology.The article was published on 2017-04-01 and is currently open access. It has received 168 citations till now. The article focuses on the topics: Nonalcoholic fatty liver disease.read more
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Screening for Nonalcoholic Fatty Liver Disease in Inflammatory Bowel Diseases: A Cohort Study Using Transient Elastography
Chiara Saroli Palumbo,Sophie Restellini,Sophie Restellini,Che-Yung Chao,Achuthan Aruljothy,Carolyne Lemieux,Gary Wild,Waqqas Afif,Peter L. Lakatos,Peter L. Lakatos,Alain Bitton,Sila Cocciolillo,Peter Ghali,Talat Bessissow,Giada Sebastiani +14 more
TL;DR: NAFLD diagnosed by TE with CAP is a frequent comorbidity in IBD patients and is associated with extrahepatic diseases, including chronic kidney disease and cardiovascular diseases.
Journal ArticleDOI
Impact of Obesity and Alanine Aminotransferase Levels on the Diagnostic Accuracy for Advanced Liver Fibrosis of Noninvasive Tools in Patients With Nonalcoholic Fatty Liver Disease
Salvatore Petta,Vincent Wai-Sun Wong,Elisabetta Bugianesi,Anna Ludovica Fracanzani,Calogero Cammà,Jean Baptiste Hiriart,Grace Lai-Hung Wong,Julien Vergniol,Anthony W.H. Chan,Aurora Giannetti,Wassil Merrouche,Henry Lik-Yuen Chan,Brigitte Le-Bail,Brigitte Le-Bail,Rosa Lombardi,Salvatore Guastella,Antonio Craxì,Victor de Ledinghen +17 more
TL;DR: LSM has a better diagnostic accuracy for advanced fibrosis than both FIB-4 and NFS only in nonobese and/or low ALT patients, and all tested noninvasive tools have overall better NPV than PPV.
Journal ArticleDOI
Clinical relevance of liver histopathology and different histological classifications of NASH in adults
Fabio Nascimbeni,Stefano Ballestri,Mariana V. Machado,Alessandro Mantovani,Helena Cortez-Pinto,Giovanni Targher,Amedeo Lonardo +6 more
TL;DR: An integrated diagnostic approach which utilizes both non-invasive tools and liver biopsy in those individual patients with suspected NAFLD is proposed, which focuses on the most burning topics to be addressed over the next five years.
Journal ArticleDOI
Reproducibility of ultrasound attenuation imaging for the noninvasive evaluation of hepatic steatosis
TL;DR: ATI showed high intra- and inter-observer reproducibility in the assessment of hepatic steatosis, and showed a significant correlation with the visual grade of hepatosis for both reviewers.
Journal ArticleDOI
Serum coding and non-coding RNAs as biomarkers of NAFLD and fibrosis severity
Stefania Di Mauro,Alessandra Scamporrino,Salvatore Petta,Francesca Urbano,Agnese Filippello,Marco Ragusa,Maria Teresa Di Martino,Francesca Scionti,Stefania Grimaudo,Rosaria Maria Pipitone,G. Privitera,Antonino Di Pino,Roberto Scicali,Luca Valenti,Paola Dongiovanni,Anna Ludovica Fracanzani,Agata Maria Rabuazzo,Antonio Craxì,Michele Purrello,Francesco Purrello,Salvatore Piro +20 more
TL;DR: This work aimed to identify differentially expressed mRNAs and non‐coding RNAs in serum samples of biopsy‐diagnosed mild and severe NAFLD patients with respect to controls and to each other.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
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Global epidemiology of nonalcoholic fatty liver disease—Meta‐analytic assessment of prevalence, incidence, and outcomes
Zobair M. Younossi,Zobair M. Younossi,Aaron B. Koenig,Dinan Abdelatif,Yousef Fazel,Linda Henry,Mark Wymer,Mark Wymer +7 more
TL;DR: As the global epidemic of obesity fuels metabolic conditions, the clinical and economic burden of NAFLD will become enormous, and random‐effects models were used to provide point estimates of prevalence, incidence, mortality and incidence rate ratios.
Journal ArticleDOI
EASL-EASD-EASO Clinical Practice Guidelines for the Management of Non-Alcoholic Fatty Liver Disease
Giulio Marchesini,Christopher P. Day,Jean-François Dufour,Ali Canbay,Valerio Nobili,Vlad Ratziu,Herbert Tilg,Michael Roden,Amalia Gastaldelli,Hannele Yki-Järvinen,Fritz Schick,Roberto Vettor,Gema Frühbeck,Lisbeth Mathus-Vliegen +13 more
TL;DR: The final purpose is to improve patient care and awareness of the importance of NAFLD, and to assist stakeholders in the decision-making process by providing evidence-based data, which also takes into consideration the burden of clinical management for the healthcare system.
Journal ArticleDOI
The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD
Paul Angulo,Jason M. Hui,Giulio Marchesini,Ellisabetta Bugianesi,Jacob George,Geoffrey C. Farrell,Felicity Enders,Sushma Saksena,Alastair D. Burt,John P. Bida,Keith D. Lindor,Schuyler O. Sanderson,Marco Lenzi,Leon A. Adams,James G. Kench,Terry M. Therneau,Christopher P. Day +16 more
TL;DR: A simple scoring system accurately separates patients with nonalcoholic fatty liver disease with and without advanced fibrosis, rendering liver biopsy for identification ofAdvanced fibrosis unnecessary in a substantial proportion of patients.
Journal ArticleDOI
Liver Fibrosis, but No Other Histologic Features, Is Associated With Long-term Outcomes of Patients With Nonalcoholic Fatty Liver Disease
Paul Angulo,David E. Kleiner,Sanne Dam-Larsen,Leon A. Adams,Einar Björnsson,Phunchai Charatcharoenwitthaya,Peter R. Mills,Jill C. Keach,Heather D. Lafferty,Alisha C. Stahler,Svanhildur Haflidadottir,Flemming Bendtsen +11 more
TL;DR: In a longitudinal study of patients with NAFLD, fibrosis stage, but no other histologic features of steatohepatitis, were associated independently with long-term overall mortality, liver transplantation, and liver-related events.