Journal ArticleDOI
In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model
Alberta Bergamo,Alessia Masi,Anna F. A. Peacock,Abraha Habtemariam,Peter J. Sadler,Gianni Sava +5 more
TLDR
Data confirm the key role of ruthenium itself in anti-metastatic activity and the activity of osmium arene complexes in other tumour models and the possibility of changing the non-arene ligands to tune the anticancer activity of Osmium in vivo.About:
This article is published in Journal of Inorganic Biochemistry.The article was published on 2010-01-01. It has received 168 citations till now. The article focuses on the topics: Cancer cell & In vivo.read more
Citations
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Metallodrugs in Medicinal Inorganic Chemistry
Katja Dralle Mjos,Chris Orvig +1 more
Journal ArticleDOI
Noble metals in medicine: Latest advances
Serenella Medici,Massimiliano Francesco Peana,Valeria Marina Nurchi,Joanna Izabela Lachowicz,Guido Crisponi,Maria Antonietta Zoroddu +5 more
TL;DR: A detailed account of the latest results of metal-based drugs and their potential uses in the cure of severe diseases is provided and the number of published studies in this field is huge.
Journal ArticleDOI
Approaching tumour therapy beyond platinum drugs : status of the art and perspectives of ruthenium drug candidates.
TL;DR: The strategies that have led to the discovery of metal-based and organometallic ruthenium-based drugs NAMI-A and KP1019 are highlighted and their main biological/pharmacological characteristics and expectations for further development are reported.
Journal ArticleDOI
Ruthenium anticancer compounds: myths and realities of the emerging metal-based drugs.
Alberta Bergamo,Gianni Sava +1 more
TL;DR: The suggestion for the future is to change the perspective when designing new chemical entities, abandoning the philosophy that guided the actual panel of ruthenium drugs and to look further into the fine mechanism by which the most relevant r Ruthenium complexes available kill the target tumour cells, then focusing on targets selective of tumours and responsible for cell growth and malignancy.
Journal ArticleDOI
The development of RAPTA compounds for the treatment of tumors
TL;DR: Ruthenium(II)-arene RAPTA-type compounds have been extensively explored for their medicinal properties and a comprehensive review of this class of compounds is provided in this article.
References
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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal ArticleDOI
New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening
Philip Skehan,Ritsa Storeng,Dominic A. Scudiero,Anne Monks,James B. McMahon,David T. Vistica,Jonathan T. Warren,Heidi R. Bokesch,Susan Kenney,Michael R. Boyd +9 more
TL;DR: The SRB assay provides a sensitive measure of drug-induced cytotoxicity, is useful in quantitating clonogenicity, and is well suited to high-volume, automated drug screening.
Journal Article
Feasibility of Drug Screening with Panels of Human Tumor Cell Lines Using a Microculture Tetrazolium Assay
Michael C. Alley,Dominic A. Scudiero,Anne Monks,Miriam L. Hursey,Maciej Czerwinski,Donald L. Fine,B. J. Abbott,Joseph G. Mayo,Robert H. Shoemaker,Michael R. Boyd +9 more
TL;DR: Since the microculture tetrazolium assay provides sensitive and reproducible indices of growth as well as drug sensitivity in individual cell lines over the course of multiple passages and several months' cultivation, it appears suitable for initial-stage in vitro drug screening.
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Structure, Recognition, and Processing of Cisplatin-DNA Adducts.
Journal Article
A Rapid in Vitro Assay for Quantitating the Invasive Potential of Tumor Cells
Adriana Albini,Yukihide Iwamoto,Hynda K. Kleinman,George R. Martin,Stuart A. Aaronson,Kozlowski Jm,R. N. McEwan +6 more
TL;DR: The results suggest that this in vitro test allows the rapid and quantitative assessment of invasiveness and a means to screen for drugs which alter the invasive phenotype of tumor cells.