Individualizing Risk Prediction for Positive Coronavirus Disease 2019 Testing: Results From 11,672 Patients.
Lara Jehi,Xinge Ji,Alex Milinovich,Serpil C. Erzurum,Brian P. Rubin,Steve Gordon,James B. Young,Michael W. Kattan +7 more
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TLDR
Relevance of age, race, gender, and socioeconomic characteristics in COVID-19-susceptibility is demonstrated and a potential modifying role of certain common vaccinations and drugs identified in drug-repurposing studies is suggested.Citations
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Temporal dynamics in total excess mortality and COVID-19 deaths in Italian cities.
Paola Michelozzi,Francesca de’Donato,Matteo Scortichini,Patrizio Pezzotti,Massimo Stafoggia,Manuela De Sario,Giuseppe Costa,Fiammetta Noccioli,Flavia Riccardo,Antonino Bella,Moreno Demaria,Pasqualino Rossi,Silvio Brusaferro,Giovanni Rezza,Marina Davoli +14 more
TL;DR: Data from the Italian rapid mortality surveillance system was used to quantify excess deaths during the epidemic, to estimate the mortality deficit during the previous months and to compare total excess mortality with deaths among positive cases of SARS-CoV-2.
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Potential effects of vaccinations on the prevention of COVID-19: rationale, clinical evidence, risks, and public health considerations.
Janet Sultana,Giampiero Mazzaglia,Nicoletta Luxi,Antonino Cancellieri,Annalisa Capuano,Carmen Ferrajolo,Chiara de Waure,Guido Ferlazzo,Gianluca Trifirò +8 more
TL;DR: This review will discuss the available immunologic and clinical evidence to support the benefit of the influenza, pneumococcal, and tuberculosis vaccines in the context of COVID-19 as well as to provide an overview on the CO VID-19-specific vaccines that are in the development pipeline.
Posted ContentDOI
Induction of trained immunity by influenza vaccination - impact on COVID-19.
Priya A. Debisarun,Katharina L. Gössling,Ozlem Bulut,Gizem Kilic,Martijn Zoodsma,Zhaoli Liu,Marina Oldenburg,Nadine Rüchel,Bowen Zhang,Cheng-Jian Xu,Cheng-Jian Xu,Patrick Struycken,Valerie A. C. M. Koeken,Valerie A. C. M. Koeken,Jorge Domínguez-Andrés,Simone J.C.F.M. Moorlag,Esther Taks,Philipp Niklas Ostermann,Lisa Müller,Heiner Schaal,Ortwin Adams,Arndt Borkhardt,Jaap ten Oever,Reinout van Crevel,Yang Li,Mihai G. Netea,Mihai G. Netea,Mihai G. Netea +27 more
TL;DR: In this article, a large academic Dutch hospital found that SARS-CoV-2 infection was less common among employees who had received a previous influenza vaccination: relative risk reductions of 37% and 49% were observed following influenza vaccination during the first and second COVID-19 waves, respectively.
Journal ArticleDOI
Can Melatonin Be a Potential "Silver Bullet" in Treating COVID-19 Patients?
TL;DR: Experimental evidence suggesting that melatonin is a potential “silver bullet” in the COVID 19 pandemic is discussed and exogenous melatonin can be an adjuvant capable of augmenting the efficacy of anti-SARS-CoV-2 vaccines.
Journal ArticleDOI
Multiple sclerosis management during the COVID-19 pandemic.
Brandon P Moss,Kedar R Mahajan,Robert A. Bermel,Kelsey Hellisz,Le H. Hua,Timothy Hudec,Scott Husak,Marisa P. McGinley,Daniel Ontaneda,Zhini Wang,Malory Weber,Paula Tagliani,Simón Cárdenas-Robledo,Ana Zabalza,Georgina Arrambide,Pere Carbonell-Mirabent,Marta Rodriguez-Barranco,Jaume Sastre-Garriga,Mar Tintoré,Xavier Montalban,Morgan Douglas,Esther Ogbuokiri,Berna Aravidis,Jeffrey A. Cohen,Ellen M. Mowry,Kathryn C. Fitzgerald +25 more
TL;DR: In this article, the authors suggest that people with MS may be at higher risk for complications from the 2019 coronavirus (COVID-19) pandemic due to use of immunomodulatory disease modifying therapies (DMTs).
References
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Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support
Paul A. Harris,Robert W. Taylor,Robert J. Thielke,Jonathon Payne,Nathaniel Gonzalez,José G. Conde +5 more
TL;DR: Research electronic data capture (REDCap) is a novel workflow methodology and software solution designed for rapid development and deployment of electronic data Capture tools to support clinical and translational research.
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Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study.
Fei Zhou,Ting Yu,Ronghui Du,Guohui Fan,Ying Liu,Zhibo Liu,Jie Xiang,Yeming Wang,Bin Song,Xiaoying Gu,Xiaoying Gu,Lulu Guan,Yuan Wei,Li Hui,Xudong Wu,Jiuyang Xu,Shengjin Tu,Yi Zhang,Hua Chen,Bin Cao +19 more
TL;DR: Wang et al. as discussed by the authors used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death, including older age, high SOFA score and d-dimer greater than 1 μg/mL.
Journal ArticleDOI
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
Nanshan Chen,Min Zhou,Xuan Dong,Jie-Ming Qu,Fengyun Gong,Yang Han,Yang Qiu,Jingli Wang,Ying Liu,Yuan Wei,Jia'an Xia,Ting Yu,Xinxin Zhang,Li Zhang +13 more
TL;DR: Characteristics of patients who died were in line with the MuLBSTA score, an early warning model for predicting mortality in viral pneumonia, and further investigation is needed to explore the applicability of the Mu LBSTA scores in predicting the risk of mortality in 2019-nCoV infection.
Journal ArticleDOI
The REDCap consortium: Building an international community of software platform partners.
Paul A. Harris,Paul A. Harris,Robert Taylor,Brenda L. Minor,Veida Elliott,Michelle Fernandez,Lindsay O'Neal,Laura McLeod,Giovanni Delacqua,Francesco Delacqua,Jacqueline Kirby,Stephany N. Duda +11 more
TL;DR: The Research Electronic Data Capture (REDCap) data management platform was developed in 2004 to address an institutional need at Vanderbilt University, then shared with a limited number of adopting sites beginning in 2006, and a broader consortium sharing and support model was created.
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Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study.
Xiaobo Yang,Yuan Yu,Jiqian Xu,Huaqing Shu,Jia'an Xia,Hong Liu,Hong Liu,Yongran Wu,Lu Zhang,Zhui Yu,Minghao Fang,Ting Yu,Yaxin Wang,Shangwen Pan,Xiaojing Zou,Shiying Yuan,You Shang,You Shang +17 more
TL;DR: The clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia who were admitted to the intensive care unit (ICU) of Wuhan Jin Yin-tan hospital between late December, 2019 and Jan 26, 2020 are described.
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