Journal ArticleDOI
Innate Immune Recognition
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TLDR
Microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens to distinguish infectious nonself from noninfectious self.Abstract:
▪ Abstract The innate immune system is a universal and ancient form of host defense against infection. Innate immune recognition relies on a limited number of germline-encoded receptors. These receptors evolved to recognize conserved products of microbial metabolism produced by microbial pathogens, but not by the host. Recognition of these molecular structures allows the immune system to distinguish infectious nonself from noninfectious self. Toll-like receptors play a major role in pathogen recognition and initiation of inflammatory and immune responses. Stimulation of Toll-like receptors by microbial products leads to the activation of signaling pathways that result in the induction of antimicrobial genes and inflammatory cytokines. In addition, stimulation of Toll-like receptors triggers dendritic cell maturation and results in the induction of costimulatory molecules and increased antigen-presenting capacity. Thus, microbial recognition by Toll-like receptors helps to direct adaptive immune responses ...read more
Citations
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Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes.
Silvia Cerboni,Nadia Jeremiah,Matteo Gentili,Ulf Gehrmann,Cécile Conrad,Marie-Claude Stolzenberg,Capucine Picard,Bénédicte Neven,Bénédicte Neven,Alain Fischer,Alain Fischer,Alain Fischer,Sebastian Amigorena,Frédéric Rieux-Laucat,Nicolas Manel +14 more
TL;DR: It is shown that STING activation reduces the proliferation of T lymphocytes and also functions intrinsically in cells of the adaptive immune system to inhibit proliferation.
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IFN-alpha enhances TLR3-mediated antiviral cytokine expression in human endothelial and epithelial cells by up-regulating TLR3 expression.
TL;DR: The results suggest that IFN-α-induced up-regulation of TLR3 expression is involved in dsRNA activated antiviral response in human epithelial and endothelial cells.
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Immunology in natura: clinical, epidemiological and evolutionary genetics of infectious diseases.
Lluis Quintana-Murci,Alexandre Alcaïs,Laurent Abel,Jean-Laurent Casanova,Jean-Laurent Casanova +4 more
TL;DR: The genetic dissection of human immunity to infection in natura provides unique immunological insight, making it an indispensable complement to experimental immunology in vitro and in vivo in plants and animals.
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The role of monocytes and inflammation in the pathophysiology of heart failure.
TL;DR: The role of monocytes and inflammation in HF is discussed, focusing on monocyte activation, mobilisation, recruitment and endothelial adherence, as well as the effects they may have on myocardial performance.
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Regulation of effector T cells by antigen-presenting cells via interaction of the C-type lectin MGL with CD45.
TL;DR: Regulation of effector T cells by MGL expressed on APCs may provide a target for regulating chronic inflammatory and autoimmune diseases.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal Article
Defective LPS signaling in C3 H/HeJ and C57 BL/10 ScCr mice: Mutations in Tlr4 Gene
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Journal ArticleDOI
A Toll-like receptor recognizes bacterial DNA.
Hiroaki Hemmi,Osamu Takeuchi,Taro Kawai,Tsuneyasu Kaisho,Shintaro Sato,Hideki Sanjo,Makoto Matsumoto,Katsuaki Hoshino,Hermann Wagner,Kiyoshi Takeda,Shizuo Akira +10 more
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Journal ArticleDOI
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.
TL;DR: It is shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces the activation of NF-κB and the production of type I interferons (IFNs).