Journal ArticleDOI
Innate Immune Recognition
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TLDR
Microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens to distinguish infectious nonself from noninfectious self.Abstract:
▪ Abstract The innate immune system is a universal and ancient form of host defense against infection. Innate immune recognition relies on a limited number of germline-encoded receptors. These receptors evolved to recognize conserved products of microbial metabolism produced by microbial pathogens, but not by the host. Recognition of these molecular structures allows the immune system to distinguish infectious nonself from noninfectious self. Toll-like receptors play a major role in pathogen recognition and initiation of inflammatory and immune responses. Stimulation of Toll-like receptors by microbial products leads to the activation of signaling pathways that result in the induction of antimicrobial genes and inflammatory cytokines. In addition, stimulation of Toll-like receptors triggers dendritic cell maturation and results in the induction of costimulatory molecules and increased antigen-presenting capacity. Thus, microbial recognition by Toll-like receptors helps to direct adaptive immune responses ...read more
Citations
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Journal ArticleDOI
Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help
Joseph C. Sun,Michael J. Bevan +1 more
TL;DR: A previously undescribed role for CD4 help in promoting protective CD8 memory development is highlighted in mice that lack CD4+ T cells that mount a primary CD8 response to Listeria monocytogenes.
Journal ArticleDOI
Pyogenic Bacterial Infections in Humans with MyD88 Deficiency
Horst von Bernuth,Capucine Picard,Capucine Picard,Zhongbo Jin,Rungnapa Pankla,Rungnapa Pankla,Hui Xiao,Cheng-Lung Ku,Cheng-Lung Ku,Maya Chrabieh,Maya Chrabieh,Imen Ben Mustapha,Imen Ben Mustapha,Imen Ben Mustapha,Pegah Ghandil,Pegah Ghandil,Yildiz Camcioglu,Júlia Vasconcelos,Nicolas Sirvent,Margarida Guedes,Artur Bonito Vitor,María José Herrero-Mata,Juan I. Aróstegui,Carlos Rodrigo,Laia Alsina,Estibaliz Ruiz-Ortiz,Manel Juan,Claudia Fortuny,Jordi Yagüe,Jordi Anton,Mariona Pascal,Huey Hsuan Chang,Lucile Janniere,Lucile Janniere,Yoann Rose,Yoann Rose,Ben Zion Garty,Helen Chapel,Andrew C. Issekutz,László Maródi,Carlos Rodríguez-Gallego,Jacques Banchereau,Laurent Abel,Laurent Abel,Xiaoxia Li,Damien Chaussabel,Anne Puel,Anne Puel,Jean-Laurent Casanova,Jean-Laurent Casanova +49 more
TL;DR: Nine children with autosomal recessive MyD88 deficiency suffered from life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, but these patients were otherwise healthy, with normal resistance to other microbes.
Journal ArticleDOI
Chemokines in Innate and Adaptive Host Defense: Basic Chemokinese Grammar for Immune Cells
Antal Rot,Ulrich H. von Andrian +1 more
TL;DR: This review presents the current understanding of the mechanisms that regulate the cellular perception and pathophysiologic meaning of chemokines and suggests that the specific patterns of homeostatic chemokine patterns are charting lymphocyte navigation routes for immune surveillance.
Journal ArticleDOI
Pattern recognition receptors: doubling up for the innate immune response.
TL;DR: Antigen presenting cells (macrophages and dendritic cells) express pattern recognition molecules that are thought to recognize foreign ligands during early phases of the immune response, suggesting that they play a dual role in normal tissue function and host defense.
References
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Journal ArticleDOI
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Journal ArticleDOI
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Journal Article
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Journal ArticleDOI
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Hiroaki Hemmi,Osamu Takeuchi,Taro Kawai,Tsuneyasu Kaisho,Shintaro Sato,Hideki Sanjo,Makoto Matsumoto,Katsuaki Hoshino,Hermann Wagner,Kiyoshi Takeda,Shizuo Akira +10 more
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Journal ArticleDOI
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.
TL;DR: It is shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces the activation of NF-κB and the production of type I interferons (IFNs).