Insertional Polymorphisms of Endogenous Feline Leukemia Viruses
Alfred L. Roca,William G. Nash,Joan C. Menninger,William J. Murphy,William J. Murphy,Stephen J. O'Brien +5 more
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TLDR
Genomic variation in enFeLVs represents a candidate for genetic influences on FeLV leukemogenesis in cats and suggests that ectopic recombination between nonhomologous subtelomeres may contribute to enFeLV distribution.Abstract:
The number, chromosomal distribution, and insertional polymorphisms of endogenous feline leukemia viruses (enFeLVs) were determined in four domestic cats (Burmese, Egyptian Mau, Persian, and nonbreed) using fluorescent in situ hybridization and radiation hybrid mapping. Twenty-nine distinct enFeLV loci were detected across 12 of the 18 autosomes. Each cat carried enFeLV at only 9 to 16 of the loci, and many loci were heterozygous for presence of the provirus. Thus, an average of 19 autosomal copies of enFeLV were present per cat diploid genome. Only five of the autosomal enFeLV sites were present in all four cats, and at only one autosomal locus, B4q15, was enFeLV present in both homologues of all four cats. A single enFeLV occurred in the X chromosome of the Burmese cat, while three to five enFeLV proviruses occurred in each Y chromosome. The X chromosome and nine autosomal enFeLV loci were telomeric, suggesting that ectopic recombination between nonhomologous subtelomeres may contribute to enFeLV distribution. Since endogenous FeLVs may affect the infectiousness or pathogenicity of exogenous FeLVs, genomic variation in enFeLVs represents a candidate for genetic influences on FeLV leukemogenesis in cats.read more
Citations
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Journal ArticleDOI
Initial sequence and comparative analysis of the cat genome
Joan Pontius,James C. Mullikin,Douglas Smith,Agencourt Sequencing Team,Kerstin Lindblad-Toh,Sante Gnerre,Michele Clamp,Jean Chang,Robert M. Stephens,Beena Neelam,Natalia Volfovsky,Alejandro A. Schäffer,Richa Agarwala,Kristina Narfström,William J. Murphy,Urs Giger,Alfred L. Roca,Agostinho Antunes,Agostinho Antunes,Marilyn Menotti-Raymond,Naoya Yuhki,Jill Pecon-Slattery,Warren E. Johnson,Guillaume Bourque,Glenn Tesler,Nisc Comparative Sequencing Program,Stephen J. O'Brien +26 more
TL;DR: The genome sequence of an inbred Abyssinian domestic cat was assembled, mapped, and annotated with a comparative approach that involved cross-reference to annotated genome assemblies of six mammals, shedding new light on the tempo and mode of gene/genome evolution in mammals and promising several research applications for the cat.
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The evolutionary dynamics of endogenous retroviruses.
TL;DR: A model that unifies current knowledge of ERV biology into a single evolutionary framework is presented that predicts the possible long-term outcomes of retroviral germline infection and can account for the variable patterns of observed ERV genetic diversity.
Journal ArticleDOI
Proliferation of Endogenous Retroviruses in the Early Stages of a Host Germ Line Invasion
TL;DR: A maximum age for enKoRV invasion of the koala germ line of approximately 22,200-49,900 years ago is suggested, although a much younger age is possible.
Journal ArticleDOI
Feline leukemia virus (FeLV) disease outcomes in a domestic cat breeding colony: relationship to endogenous FeLV and other chronic viral infections.
Jordan A. Powers,Elliott S. Chiu,Simona Kraberger,Melody E. Roelke-Parker,Isabella Lowery,Katelyn Erbeck,Ryan M. Troyer,Scott Carver,Sue VandeWoude +8 more
TL;DR: Insight is provided into the interplay between endogenous and exogenous FeLV during naturally occurring disease and reveals striking variation in the infection patterns among four chronic viral infections of domestic cats.
Journal ArticleDOI
Sequences, Annotation and Single Nucleotide Polymorphism of the Major Histocompatibility Complex in the Domestic Cat
TL;DR: Two sequences of major histocompatibility complex (MHC) regions in the domestic cat, 2.976 and 0.362 Mbps, which were separated by an ancient chromosome break (55-80 MYA) and followed by a chromosomal inversion were annotated in detail.
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