Insulin-FOXO3 signaling modulates circadian rhythms via regulation of clock transcription
Inês Chaves,Gijsbertus T. J. van der Horst,Raymond D. Schellevis,Romana M. Nijman,Marian J. A. Groot Koerkamp,Frank C. P. Holstege,Marten P. Smidt,Marten P. Smidt,Marco F.M. Hoekman,Marco F.M. Hoekman +9 more
TLDR
It is shown that insulin-phosphatidylinositol 3-kinase (PI3K)-Forkhead box class O3 (FOXO3) signaling is required for circadian rhythmicity in the liver via regulation of Clock, and insulin, a major regulator of FOXO activity, regulates Clock levels in a PI3K- and FOXO3-dependent manner.About:
This article is published in Current Biology.The article was published on 2014-06-02 and is currently open access. It has received 80 citations till now. The article focuses on the topics: Circadian clock & CLOCK.read more
Citations
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Journal ArticleDOI
Clock-Talk: Interactions between central and peripheral circadian oscillators in mammals
Ueli Schibler,Ivana Gotic,Camille Saini,Pascal Gos,Thomas Curie,Yann Emmenegger,Flore Sinturel,Pauline Gosselin,Alan Gerber,Fabienne Fleury-Olela,Gianpaolo Rando,Maud Demarque,Paul Franken +12 more
TL;DR: In mice and rats, feeding-fasting rhythms, which are driven by the SCN through rest-activity cycles, are the most potent Zeitgebers for the circadian oscillators of peripheral organs.
Journal ArticleDOI
Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways.
Anorut Jenwitheesuk,Chutikorn Nopparat,Sujira Mukda,Prapimpun Wongchitrat,Piyarat Govitrapong +4 more
TL;DR: This review summarizes the current understanding of how melatonin, together with molecular, cellular and systemic energy metabolisms, regulates epigenetic processes in the neurons and will lead to a greater understanding of molecular epigenetic aging of the brain and anti-aging mechanisms to increase lifespan under healthy conditions.
Journal ArticleDOI
Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation.
Swenja Kröller-Schön,Andreas Daiber,Sebastian Steven,Matthias Oelze,Katie Frenis,Sanela Kalinovic,Axel Heimann,Frank P. Schmidt,Antonio Pinto,Miroslava Kvandova,Ksenija Vujacic-Mirski,Konstantina Filippou,Markus Dudek,Markus Bosmann,Matthias Klein,Tobias Bopp,Omar Hahad,Philipp S. Wild,Katrin Frauenknecht,Axel Methner,Erwin R. Schmidt,Steffen Rapp,Hanke Mollnau,Thomas Münzel +23 more
TL;DR: Around-the-clock aircraft noise of the mice caused the most pronounced vascular effects and dysregulation of Foxo3/circadian clock as revealed by next generation sequencing (NGS), suggesting impaired sleep quality in exposed mice and preventive measures that reduce night-time aircraft noise are warranted.
Journal ArticleDOI
Peripheral Circadian Clocks Mediate Dietary Restriction-Dependent Changes in Lifespan and Fat Metabolism in Drosophila.
Subhash D. Katewa,Kazutaka Akagi,Neelanjan Bose,Kuntol Rakshit,Timothy Camarella,Xiangzhong Zheng,David Hall,Sonnet S. Davis,Christopher S. Nelson,Rachel B. Brem,Arvind Ramanathan,Amita Sehgal,Jadwiga M. Giebultowicz,Pankaj Kapahi +13 more
TL;DR: It is reported here that the core circadian clock genes, timeless and period, are required for the metabolic and lifespan responses to DR in Drosophila, and a critical role for specific clock genes in modulating the effects of nutrient manipulation on fat metabolism and aging is identified.
Journal ArticleDOI
Etiology of Metabolic Syndrome and Dietary Intervention.
TL;DR: In this review, the proposed and demonstrated mechanisms of MetS pathogenesis are discussed and demonstrated, and different interventions are discussed, so that health practitioners can have a better understanding of the most recent research progress and have available references for their daily practice.
References
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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.
TL;DR: By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies.
Journal ArticleDOI
Coordinated transcription of key pathways in the mouse by the circadian clock.
Satchidananda Panda,Marina P. Antoch,Brooke H. Miller,Andrew I. Su,Andrew I. Su,Andrew B. Schook,Marty Straume,Peter G. Schultz,Peter G. Schultz,Steve A. Kay,Steve A. Kay,Joseph S. Takahashi,John B. Hogenesch +12 more
TL;DR: Genetic and genomic analysis suggests that a relatively small number of output genes are directly regulated by core oscillator components, and major processes regulated by the SCN and liver were found to be under circadian regulation.
Journal ArticleDOI
Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
Francesca Damiola,Nguyet Le Minh,Nicolas Preitner,Benoît Kornmann,Fabienne Fleury-Olela,Ueli Schibler +5 more
TL;DR: It is shown that temporal feeding restriction under light-dark or dark-dark conditions can change the phase of circadian gene expression in peripheral cell types by up to 12 h while leaving thephase of cyclic gene expressionIn the SCN unaffected.
Journal ArticleDOI
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues
Seung Hee Yoo,Shin Yamazaki,Shin Yamazaki,Phillip L. Lowrey,Kazuhiro Shimomura,Caroline H. Ko,Caroline H. Ko,Ethan D. Buhr,Sandra M. Siepka,Hee Kyung Hong,Won Jun Oh,Ook Joon Yoo,Michael Menaker,Joseph S. Takahashi +13 more
TL;DR: It is demonstrated that peripheral tissues express self-sustained, rather than damped, circadian oscillations and the existence of organ-specific synchronizers of circadian rhythms at the cell and tissue level is suggested.
Journal ArticleDOI
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
Scott Ogg,Suzanne Paradis,Shoshanna Gottlieb,Garth I. Patterson,Linda Lee,Heidi A. Tissenbaum,Gary Ruvkun +6 more
TL;DR: It is shown that null mutations in Daf-16 suppress the effects of mutations in daf-2 or age-1; lack of dAF-16 bypasses the need for this insulin receptor-like signalling pathway.
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