Intestinal Permeability Defects: Is It Time to Treat?
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TLDR
The correlation between increased intestinal permeability and disease has caught the attention of the public, leading to a rise in popularity of the diagnosis of "leaky gut syndrome," which encompasses a range of systemic disorders.About:
This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2013-09-01 and is currently open access. It has received 268 citations till now. The article focuses on the topics: Intestinal mucosa & Intestinal permeability.read more
Citations
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The intestinal epithelial barrier: a therapeutic target?
TL;DR: Mechanisms of intestinal barrier loss and the role of intestinal epithelial barrier function in pathogenesis of both intestinal and systemic diseases are reviewed and a discussion of potential strategies to restore the epithelium is discussed.
Journal ArticleDOI
Leaky gut: mechanisms, measurement and clinical implications in humans.
TL;DR: Clinicians are to discuss the components of the intestinal barrier, the diverse measurements of intestinal permeability, their perturbation in non-inflammatory ‘stressed states’ and the impact of treatment with dietary factors.
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Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions
Chaithanya Chelakkot,Youngwoo Choi,Dae-Kyum Kim,Hyun Taek Park,Jaewang Ghim,Yonghoon Kwon,Jinseong Jeon,Min-Seon Kim,Young Koo Jee,Yong Song Gho,Hae-Sim Park,Yoon-Keun Kim,Sung H Ryu +12 more
TL;DR: Results imply that AmEVs may act as a functional moiety for controlling gut permeability and that the regulation of intestinal barrier integrity can improve metabolic functions in HFD-fed mice.
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Leaky Gut As a Danger Signal for Autoimmune Diseases
TL;DR: It is hypothesized that modulating the gut microbiota can serve as a potential method for regulating intestinal permeability and may help to alter the course of autoimmune diseases in susceptible individuals.
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The gut microbiome and diet in psychiatry: focus on depression.
TL;DR: Evidence is provided for the gut microbiota as a key factor mediating the link between diet and depressive illness and promise is suggested in the development of interventions targeting the Gut microbiota for the prevention and treatment of common mental health disorders.
References
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Intestinal absorptive capacity, intestinal permeability and jejunal histology in HIV and their relation to diarrhoea.
J Keating,Ingvar Bjarnason,S Somasundaram,A Macpherson,N Francis,Ashley B. Price,D Sharpstone,J Smithson,I S Menzies,Brian Gazzard +9 more
TL;DR: Malabsorption, which has nutritional implications, relates more to immune suppression than jejunal morphological changes, and increased intestinal permeability are common in AIDS patients.
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Responses of small intestinal architecture and function over time to environmental factors in a tropical population
Paul Kelly,Ian S Menzies,Roger Crane,Isaac Zulu,Carole D. Nickols,Roger Feakins,James Mwansa,Victor Mudenda,Max Katubulushi,Steve Greenwald,Michael J.G. Farthing +10 more
TL;DR: The whole cohort had structural and functional evidence of tropical enteropathy, but structure and function were only weakly correlated, and seasonal variation was observed in villous height, xylose recovery, and permeability.
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Small intestinal transit, absorption, and permeability in patients with AIDS with and without diarrhoea
D Sharpstone,P Neild,Roger Crane,Chris Taylor,C Hodgson,R Sherwood,Brian Gazzard,Ingvar Bjarnason +7 more
TL;DR: Small bowel transit is accelerated in many patients with AIDS, particularily in protozoal diarrhoea, but is not the sole explanation for malabsorption of monosaccharides.
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A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing.
TL;DR: An abnormal lactulose breath test is more common in fibromyalgia than IBS and correlates with somatic pain, in contrast with IBS.
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Effects of phlorizin and sodium on glucose-elicited alterations of cell junctions in intestinal epithelia.
TL;DR: It is shown that phlorizin blocks a resistance decrease elicited by glucose and demonstrate that substitution of choline for sodium also prevents the response, and that in vivo perfusion studies suggest that although, at 25 mM luminal glucose, virtually all glucose absorption is transcellular, at a luminals glucose concentration of 125 mM approximately 30% of glucose absorption occurs paracellularly because of solvent drag across tight junctions of altered permeability.