Intestinal Permeability Defects: Is It Time to Treat?
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TLDR
The correlation between increased intestinal permeability and disease has caught the attention of the public, leading to a rise in popularity of the diagnosis of "leaky gut syndrome," which encompasses a range of systemic disorders.About:
This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2013-09-01 and is currently open access. It has received 268 citations till now. The article focuses on the topics: Intestinal mucosa & Intestinal permeability.read more
Citations
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Journal ArticleDOI
The intestinal epithelial barrier: a therapeutic target?
TL;DR: Mechanisms of intestinal barrier loss and the role of intestinal epithelial barrier function in pathogenesis of both intestinal and systemic diseases are reviewed and a discussion of potential strategies to restore the epithelium is discussed.
Journal ArticleDOI
Leaky gut: mechanisms, measurement and clinical implications in humans.
TL;DR: Clinicians are to discuss the components of the intestinal barrier, the diverse measurements of intestinal permeability, their perturbation in non-inflammatory ‘stressed states’ and the impact of treatment with dietary factors.
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Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions
Chaithanya Chelakkot,Youngwoo Choi,Dae-Kyum Kim,Hyun Taek Park,Jaewang Ghim,Yonghoon Kwon,Jinseong Jeon,Min-Seon Kim,Young Koo Jee,Yong Song Gho,Hae-Sim Park,Yoon-Keun Kim,Sung H Ryu +12 more
TL;DR: Results imply that AmEVs may act as a functional moiety for controlling gut permeability and that the regulation of intestinal barrier integrity can improve metabolic functions in HFD-fed mice.
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Leaky Gut As a Danger Signal for Autoimmune Diseases
TL;DR: It is hypothesized that modulating the gut microbiota can serve as a potential method for regulating intestinal permeability and may help to alter the course of autoimmune diseases in susceptible individuals.
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The gut microbiome and diet in psychiatry: focus on depression.
TL;DR: Evidence is provided for the gut microbiota as a key factor mediating the link between diet and depressive illness and promise is suggested in the development of interventions targeting the Gut microbiota for the prevention and treatment of common mental health disorders.
References
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Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non-alcoholic steatohepatitis.
Ashkan Farhadi,Sushama Gundlapalli,Maliha Shaikh,Constantine T. Frantzides,Laura Harrell,Mary Morrissey Kwasny,Ali Keshavarzian +6 more
TL;DR: This work investigated one possible mechanism for the endotoxaemia – disruption of intestinal barrier integrity – and found it to be related to hepatic oxidative stress triggered by elevated levels of endotoxin.
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Amylase-resistant starch plus oral rehydration solution for cholera.
Balakrishnan S. Ramakrishna,S. Venkataraman,Pugazhendhi Srinivasan,Pratap Dash,Graeme P. Young,Henry J. Binder +5 more
TL;DR: The addition of a resistant starch to oral rehydration solution reduces fecal fluid loss and shortens the duration of diarrhea in adolescents and adults with cholera.
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Paracellular ion channel at the tight junction.
TL;DR: The results support the hypothesis that discrete ion channels are present at the tight junction, and a new class of paracellular-tight junction channels (PTJC) facilitates the transport of ions between separate extracellular compartments.
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Intestinal permeability in patients with eczema and food allergy
TL;DR: There is an intestinal mucosal defect in eczema which exists whether or not there is coexistent food allergy, and PEG was used as a probe molecule to investigate intestinal absorption.
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Intestinal permeability test as a predictor of clinical course in Crohn’s disease
Renata D'Incà,V. Di Leo,G Corrao,Diego Martines,Anna D'Odorico,C Mestriner,C. Venturi,G. Longo,G.C. Sturniolo +8 more
TL;DR: The L/M test identifies Crohn's disease patients in apparent remission, but with a high risk of clinical relapse, better than clinical and biochemical indices.