Intestinal Permeability Defects: Is It Time to Treat?
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TLDR
The correlation between increased intestinal permeability and disease has caught the attention of the public, leading to a rise in popularity of the diagnosis of "leaky gut syndrome," which encompasses a range of systemic disorders.About:
This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2013-09-01 and is currently open access. It has received 268 citations till now. The article focuses on the topics: Intestinal mucosa & Intestinal permeability.read more
Citations
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Systematic review: bile acids and intestinal inflammation-luminal aggressors or regulators of mucosal defence?
Polychronis Pavlidis,Nick Powell,Royce P Vincent,D Ehrlich,Ingvar Bjarnason,Bu'Hussain Hayee +5 more
TL;DR: Inflammatory bowel diseases (IBD), comprising Crohn's disease and ulcerative colitis, are chronic conditions attributed to an aberrant immune response to luminal triggers and a pathogenic role for bile acids in this context is suggested.
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Gut Microbiota Dysbiosis as Risk and Premorbid Factors of IBD and IBS Along the Childhood–Adulthood Transition
Lorenza Putignani,Federica Del Chierico,Pamela Vernocchi,Michele Cicala,Salvatore Cucchiara,Bruno Dallapiccola +5 more
TL;DR: Large-scale gut microbiota signatures and host inflammation patterns may be integrated with dietary habits, under genetic and epigenetic constraints, providing gut dysbiosis profiles acting as risk predictors of IBD or IBS in preclinical cases.
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The effect of age on the intestinal mucus thickness, microbiota composition and immunity in relation to sex in mice
Marlies Elderman,Bruno Sovran,Floor Hugenholtz,Katrine Graversen,Myrte Huijskes,Eva Houtsma,Clara Belzer,Mark V. Boekschoten,Paul de Vos,Jan Dekker,Jerry M. Wells,Marijke M. Faas +11 more
TL;DR: The effect of age on mucus thickness, intestinal microbiota composition and immune composition in relation to sex is investigated to contribute to a better understanding of the interplay between mucus-microbiota-and immune responses and ultimately may lead to more tailored design of strategies to modulate mucus production in targeted groups.
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Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis
W. Vallen Graham,W. Vallen Graham,Wei-Qi He,Wei-Qi He,Amanda M. Marchiando,Juanmin Zha,Juanmin Zha,Gurminder Singh,Gurminder Singh,Hua-Shan Li,Amlan Biswas,Ma. Lora Drizella M. Ong,Zhi-Hui Jiang,Wangsun Choi,Harmon J. Zuccola,Yitang Wang,James P. Griffith,Jingshing Wu,Harry J. Rosenberg,Yingmin Wang,Scott B. Snapper,David A. Ostrov,Stephen C. Meredith,Lawrence W. Miller,Jerrold R. Turner,Jerrold R. Turner +25 more
TL;DR: Divertin blocks acute, tumor necrosis factor-induced MLCK1 recruitment as well as downstream myosin light chain (MLC) phosphorylation, barrier loss, and diarrhea in vitro and in vivo.
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Biomarkers of gut barrier failure in the ICU.
Gaël Piton,Gilles Capellier +1 more
TL;DR: Enterocyte biomarkers may help the intensivist to identify patients presenting with intestinal damage, and who are at risk of bacterial translocation and systemic inflammatory response syndrome, as well as those with decreased enterocyte function, at riskof malabsorption.
References
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Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Jason M. Brenchley,David Price,Timothy W. Schacker,Tedi E. Asher,Guido Silvestri,Srinivas S. Rao,Zachary Kazzaz,Ethan Bornstein,Olivier Lambotte,Daniel M. Altmann,Bruce R. Blazar,Benigno Rodriguez,Leia Teixeira-Johnson,Alan L. Landay,Jeffrey N. Martin,Frederick Hecht,Louis J. Picker,Michael M. Lederman,Steven G. Deeks,Daniel C. Douek +19 more
TL;DR: It is shown that increased lipopolysaccharide is bioactive in vivo and correlates with measures of innate and adaptive immune activation, which establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection.
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Intestinal mucosal barrier function in health and disease.
TL;DR: Recent advances have uncovered mechanisms by which the intestinal mucosal barrier is regulated in response to physiological and immunological stimuli, along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease.
Journal ArticleDOI
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
TL;DR: It is shown that circulating microbial products, probably derived from the gastrointestinal tract, are a cause of HIV-related systemic immune activation and increased lipopolysaccharide is bioactive in vivo and correlates with measures of innate and adaptive immune activation.
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The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
Malin E. V. Johansson,Mia Phillipson,Joel Petersson,Anna Velcich,Lena Holm,Gunnar C. Hansson +5 more
TL;DR: Findings show that the Muc2 mucin can build a mucus barrier that separates bacteria from the colon epithelia and suggest that defects in this mucus can cause colon inflammation.
Journal ArticleDOI
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Li Wen,Ruth E. Ley,Ruth E. Ley,Pavel Volchkov,Peter B. Stranges,Lia Avanesyan,Austin C. Stonebraker,Changyun Hu,F. Susan Wong,Gregory L. Szot,Jeffrey A. Bluestone,Jeffrey I. Gordon,Alexander V. Chervonsky +12 more
TL;DR: It is found that MyD88 deficiency changes the composition of the distal gut microbiota, and that exposure to the microbiota of specific pathogen-free MyD 88-negative NOD donors attenuates T1D in germ-free NOD recipients.