Intestinal Permeability Defects: Is It Time to Treat?
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TLDR
The correlation between increased intestinal permeability and disease has caught the attention of the public, leading to a rise in popularity of the diagnosis of "leaky gut syndrome," which encompasses a range of systemic disorders.About:
This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2013-09-01 and is currently open access. It has received 268 citations till now. The article focuses on the topics: Intestinal mucosa & Intestinal permeability.read more
Citations
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Journal ArticleDOI
The intestinal epithelial barrier: a therapeutic target?
TL;DR: Mechanisms of intestinal barrier loss and the role of intestinal epithelial barrier function in pathogenesis of both intestinal and systemic diseases are reviewed and a discussion of potential strategies to restore the epithelium is discussed.
Journal ArticleDOI
Leaky gut: mechanisms, measurement and clinical implications in humans.
TL;DR: Clinicians are to discuss the components of the intestinal barrier, the diverse measurements of intestinal permeability, their perturbation in non-inflammatory ‘stressed states’ and the impact of treatment with dietary factors.
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Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions
Chaithanya Chelakkot,Youngwoo Choi,Dae-Kyum Kim,Hyun Taek Park,Jaewang Ghim,Yonghoon Kwon,Jinseong Jeon,Min-Seon Kim,Young Koo Jee,Yong Song Gho,Hae-Sim Park,Yoon-Keun Kim,Sung H Ryu +12 more
TL;DR: Results imply that AmEVs may act as a functional moiety for controlling gut permeability and that the regulation of intestinal barrier integrity can improve metabolic functions in HFD-fed mice.
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Leaky Gut As a Danger Signal for Autoimmune Diseases
TL;DR: It is hypothesized that modulating the gut microbiota can serve as a potential method for regulating intestinal permeability and may help to alter the course of autoimmune diseases in susceptible individuals.
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The gut microbiome and diet in psychiatry: focus on depression.
TL;DR: Evidence is provided for the gut microbiota as a key factor mediating the link between diet and depressive illness and promise is suggested in the development of interventions targeting the Gut microbiota for the prevention and treatment of common mental health disorders.
References
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Intestinal permeability is increased in bronchial asthma
TL;DR: Intestinal permeability is increased in children with asthma, suggesting that the whole mucosal system may be affected, according to one study of adult asthmatics.
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Noninvasive in vivo analysis of human small intestinal paracellular absorption: Regulation by Na+-glucose cotransport
TL;DR: Intestinal paracellular absorption of creatinine is increased by the presence of luminal glucose, consistent with in vivo human regulation of mucosal permeability by Na+–glucose cotransport.
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Intestinal glucose transport using perfused rat jejunum in vivo: model analysis and derivation of corrected kinetic constants.
TL;DR: In this article, the authors defined the transport model that best fits experimental data and devised methods to obtain the kinetic constants, corrected for diffusion barrier resistance, with this model, and fitted the data to the transport equations that describe the three models with appropriate diffusion barrier corrections.
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Altered intestinal permeability in patients with primary fibromyalgia and in patients with complex regional pain syndrome
TL;DR: The IPs in primary FM and, unexpectedly, CRPS are increased, and the implication of altered IP in the disease pathophysiology of FM and CRPS is stimulated.
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Glutamine stabilizes intestinal permeability and reduces pancreatic infection in acute experimental pancreatitis
Thomas Foitzik,M. Stufler,Hubert G. Hotz,J. Klinnert,J. Wagner,Andrew L. Warshaw,Jörg-Dieter Schulzke,Michael Fromm,Heinz-Johannes Buhr +8 more
TL;DR: Adding GLN to standard TPN not only reduces the permeability of the colon but decreases pancreatic infections in acute necrotizing pancreatitis in the rat, confirming previous reports that GLN decreases bacterial translocation by stabilizing the intestinal mucosal barrier.