Intestinal Permeability Defects: Is It Time to Treat?
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TLDR
The correlation between increased intestinal permeability and disease has caught the attention of the public, leading to a rise in popularity of the diagnosis of "leaky gut syndrome," which encompasses a range of systemic disorders.About:
This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2013-09-01 and is currently open access. It has received 268 citations till now. The article focuses on the topics: Intestinal mucosa & Intestinal permeability.read more
Citations
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Journal ArticleDOI
The intestinal epithelial barrier: a therapeutic target?
TL;DR: Mechanisms of intestinal barrier loss and the role of intestinal epithelial barrier function in pathogenesis of both intestinal and systemic diseases are reviewed and a discussion of potential strategies to restore the epithelium is discussed.
Journal ArticleDOI
Leaky gut: mechanisms, measurement and clinical implications in humans.
TL;DR: Clinicians are to discuss the components of the intestinal barrier, the diverse measurements of intestinal permeability, their perturbation in non-inflammatory ‘stressed states’ and the impact of treatment with dietary factors.
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Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions
Chaithanya Chelakkot,Youngwoo Choi,Dae-Kyum Kim,Hyun Taek Park,Jaewang Ghim,Yonghoon Kwon,Jinseong Jeon,Min-Seon Kim,Young Koo Jee,Yong Song Gho,Hae-Sim Park,Yoon-Keun Kim,Sung H Ryu +12 more
TL;DR: Results imply that AmEVs may act as a functional moiety for controlling gut permeability and that the regulation of intestinal barrier integrity can improve metabolic functions in HFD-fed mice.
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Leaky Gut As a Danger Signal for Autoimmune Diseases
TL;DR: It is hypothesized that modulating the gut microbiota can serve as a potential method for regulating intestinal permeability and may help to alter the course of autoimmune diseases in susceptible individuals.
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The gut microbiome and diet in psychiatry: focus on depression.
TL;DR: Evidence is provided for the gut microbiota as a key factor mediating the link between diet and depressive illness and promise is suggested in the development of interventions targeting the Gut microbiota for the prevention and treatment of common mental health disorders.
References
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A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease
Yevgeny Zolotarevsky,Gail Hecht,Athanasia Koutsouris,Deborah E. Gonzalez,Cliff Quan,Jeffrey Tom,Randall J. Mrsny,Jerrold R. Turner,Jerrold R. Turner +8 more
TL;DR: PIK may be the prototype for a new class of targeted therapeutic agents that can restore barrier function in intestinal disease states and reverse MLC phosphorylation increases and TER decreases induced by TNF-alpha and IFN-gamma.
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Increased intestinal permeability precedes clinical onset of type 1 diabetes.
Emanuele Bosi,Laura Molteni,Maria Grazia Radaelli,L. Folini,Isabella Fermo,Elena Bazzigaluppi,Lorenzo Piemonti,M. R. Pastore,Rita Paroni +8 more
TL;DR: These findings indicate the presence of a subclinical enteropathy associated with type 1 diabetes that is already detectable before clinical onset of the disease, and suggest that the small intestine is an organ participating in the pathogenetic process of type 1 Diabetes.
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Increased Intestinal Permeability Is Associated with the Development of Multiple Organ Dysfunction Syndrome in Critically Ill ICU Patients
Christopher J. Doig,Lloyd R. Sutherland,J. Dean Sandham,Gordon H. Fick,Marja J. Verhoef,Jon Meddings +5 more
TL;DR: The development ofMODS is associated with an abnormal and severe derangement of IP that is detectable prior to the onset of the syndrome, lending credence to the premise that gastrointestinal (GI) dysfunction may be causally associated with the development of MODS in the critically ill patient.
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Genetic basis for increased intestinal permeability in families with Crohn's disease: role of CARD15 3020insC mutation?
Sabine Buhner,Carsten Büning,Janine Genschel,K. Kling,Dana Herrmann,Axel Dignass,I Kuechler,S Krueger,H. Schmidt,H. Lochs +9 more
TL;DR: In healthy first degree relatives, high mucosal permeability is associated with the presence of a CARD15 3020insC mutation, indicating that genetic factors may be involved in impairment of intestinal barrier function in families with IBD.
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Epithelial Tight Junctions in Intestinal Inflammation
Joerg D. Schulzke,Svenja Ploeger,Maren Amasheh,Anja Fromm,Sebastian Zeissig,Hanno Troeger,Jan F. Richter,Christian Bojarski,Michael Schumann,Michael Fromm +9 more
TL;DR: Immune regulation of epithelial functions by cytokines may cause barrier dysfunction not only by tight junction impairments but also by apoptotic leaks, transcytotic mechanisms, and mucosal gross lesions.