Intestinal Permeability Defects: Is It Time to Treat?
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TLDR
The correlation between increased intestinal permeability and disease has caught the attention of the public, leading to a rise in popularity of the diagnosis of "leaky gut syndrome," which encompasses a range of systemic disorders.About:
This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2013-09-01 and is currently open access. It has received 268 citations till now. The article focuses on the topics: Intestinal mucosa & Intestinal permeability.read more
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Book ChapterDOI
Early Nutrition and its Effect on the Development of Allergic Diseases
TL;DR: The role of early nutrition on specific allergic conditions, focused on atopic dermatitis, the most common allergic disease in infancy, is reviewed, and on emerging evidence related to the role of nutrition in food protein induced enterocolitis syndrome and eosinophilic esophagitis is reviewed.
Health beneficial effects of carotenoids & polyphenols from locally grown fruits & vegetables determined by in-vitro assessment of Caco-2 cells following simulated gastro-intestinal digestion
TL;DR: Kaulmann et al. as discussed by the authors focused on the characterization of local plums and cabbage varieties, rich in carotenoids and polyphenols, their bioavailability, and aspects related to inflammatory responses as occurring in inflammatory bowel diseases.
Journal ArticleDOI
Gut microbiota composition is altered in a preclinical model of type 1 diabetes mellitus: Influence on gut steroids, permeability, and cognitive abilities
Silvia Diviccaro,Eva Falvo,Rocco Piazza,Lucia Cioffi,M. Herian,Paola Brivio,Francesca Calabrese,Silvia Giatti,Donatella Caruso,Roberto Cosimo Melcangi +9 more
TL;DR: In this article , the effects of Type 1 diabetes mellitus (T1DM) on the Gut Microbiome and the Brain: Mechanisms & Maladies were explored in a female rat.
Journal ArticleDOI
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors
Yueshan Sun,Hong Li,Lei Liu,Xiaoqin Bai,Liping Wu,Jing Shan,Xiaobin Sun,Qiong Wang,Yuanbiao Guo +8 more
TL;DR: In this paper , a nonfluorinated Lidocaine analog 2-diethylamino-N-2,5-dimethylphenyl acetamide (JM25-1) was used to stabilise the intestinal barrier.
References
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Journal ArticleDOI
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Jason M. Brenchley,David Price,Timothy W. Schacker,Tedi E. Asher,Guido Silvestri,Srinivas S. Rao,Zachary Kazzaz,Ethan Bornstein,Olivier Lambotte,Daniel M. Altmann,Bruce R. Blazar,Benigno Rodriguez,Leia Teixeira-Johnson,Alan L. Landay,Jeffrey N. Martin,Frederick Hecht,Louis J. Picker,Michael M. Lederman,Steven G. Deeks,Daniel C. Douek +19 more
TL;DR: It is shown that increased lipopolysaccharide is bioactive in vivo and correlates with measures of innate and adaptive immune activation, which establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection.
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Intestinal mucosal barrier function in health and disease.
TL;DR: Recent advances have uncovered mechanisms by which the intestinal mucosal barrier is regulated in response to physiological and immunological stimuli, along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease.
Journal ArticleDOI
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
TL;DR: It is shown that circulating microbial products, probably derived from the gastrointestinal tract, are a cause of HIV-related systemic immune activation and increased lipopolysaccharide is bioactive in vivo and correlates with measures of innate and adaptive immune activation.
Journal ArticleDOI
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
Malin E. V. Johansson,Mia Phillipson,Joel Petersson,Anna Velcich,Lena Holm,Gunnar C. Hansson +5 more
TL;DR: Findings show that the Muc2 mucin can build a mucus barrier that separates bacteria from the colon epithelia and suggest that defects in this mucus can cause colon inflammation.
Journal ArticleDOI
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Li Wen,Ruth E. Ley,Ruth E. Ley,Pavel Volchkov,Peter B. Stranges,Lia Avanesyan,Austin C. Stonebraker,Changyun Hu,F. Susan Wong,Gregory L. Szot,Jeffrey A. Bluestone,Jeffrey I. Gordon,Alexander V. Chervonsky +12 more
TL;DR: It is found that MyD88 deficiency changes the composition of the distal gut microbiota, and that exposure to the microbiota of specific pathogen-free MyD 88-negative NOD donors attenuates T1D in germ-free NOD recipients.