Intestinal Permeability Defects: Is It Time to Treat?
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TLDR
The correlation between increased intestinal permeability and disease has caught the attention of the public, leading to a rise in popularity of the diagnosis of "leaky gut syndrome," which encompasses a range of systemic disorders.About:
This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2013-09-01 and is currently open access. It has received 268 citations till now. The article focuses on the topics: Intestinal mucosa & Intestinal permeability.read more
Citations
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Exploration of Potential Molecular Targets of Dexmedetomidine in the Intestinal Repair of Burnt Rats.
TL;DR: Wang et al. as discussed by the authors explored the potential specific targets of Dex in intestinal barrier repair in burn rats model, and differentially expressed proteins were further adopted to protein-protein interaction network analysis, Gene Ontology analysis (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis.
Journal ArticleDOI
Exploring the mechanism of Xingpi Capsule in diarrhea predominant-irritable bowel syndrome treatment based on multiomics technology.
Weina Qian,Weili Li,Xiao-Yi Chen,Lingwen Cui,Xiang Hong Liu,Jun-Kai Yao,Xiaoping Wang,Yizhou Liu,Chun Li,Yong Wang,Wei Wang +10 more
TL;DR: Xingpi Capsule (XP) is a popular over-the-counter herbal medicine in China, which plays a prominent role in treating diarrhea-predominant irritable bowel syndrome (IBS-D) as discussed by the authors .
Effects of lifestyle and environmental factors on intestinal epithelial cell morphogenesis
TL;DR: For this thesis, the direct effects of different factors known from epidemiologic and clinical studies, such as cigarette smoking and the presence of pro-inflammatory cytokines on the self-organization in this cell model were assessed, furthered insights into (pathological) environmental-epithelial interplay.
Posted ContentDOI
Chemotherapy-induced intestinal injury promotes Galectin-9-driven modulation of T cell function
S.A. Jansen,Alessandro Cutilli,Coco de Koning,Marliek van Hoesel,Leire Saiz Sierra,Stefan Nierkens,Michal Mokry,Edward E. S. Nieuwenhuis,Alan M. Hanash,Enric Mocholi,Paul J. Coffer,Caroline A. Lindemans +11 more
TL;DR: In this article , a 3D model system was developed to study the direct effect of chemotherapy-induced intestinal epithelial damage on T cell behavior in allogeneic hematopoietic cell transplantation.
References
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Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Jason M. Brenchley,David Price,Timothy W. Schacker,Tedi E. Asher,Guido Silvestri,Srinivas S. Rao,Zachary Kazzaz,Ethan Bornstein,Olivier Lambotte,Daniel M. Altmann,Bruce R. Blazar,Benigno Rodriguez,Leia Teixeira-Johnson,Alan L. Landay,Jeffrey N. Martin,Frederick Hecht,Louis J. Picker,Michael M. Lederman,Steven G. Deeks,Daniel C. Douek +19 more
TL;DR: It is shown that increased lipopolysaccharide is bioactive in vivo and correlates with measures of innate and adaptive immune activation, which establish a mechanism for chronic immune activation in the context of a compromised gastrointestinal mucosal surface and provide new directions for therapeutic interventions that modify the consequences of acute HIV infection.
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Intestinal mucosal barrier function in health and disease.
TL;DR: Recent advances have uncovered mechanisms by which the intestinal mucosal barrier is regulated in response to physiological and immunological stimuli, along with evidence that this regulation shapes mucosal immune responses in the gut and, when dysfunctional, may contribute to disease.
Journal ArticleDOI
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
TL;DR: It is shown that circulating microbial products, probably derived from the gastrointestinal tract, are a cause of HIV-related systemic immune activation and increased lipopolysaccharide is bioactive in vivo and correlates with measures of innate and adaptive immune activation.
Journal ArticleDOI
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
Malin E. V. Johansson,Mia Phillipson,Joel Petersson,Anna Velcich,Lena Holm,Gunnar C. Hansson +5 more
TL;DR: Findings show that the Muc2 mucin can build a mucus barrier that separates bacteria from the colon epithelia and suggest that defects in this mucus can cause colon inflammation.
Journal ArticleDOI
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Li Wen,Ruth E. Ley,Ruth E. Ley,Pavel Volchkov,Peter B. Stranges,Lia Avanesyan,Austin C. Stonebraker,Changyun Hu,F. Susan Wong,Gregory L. Szot,Jeffrey A. Bluestone,Jeffrey I. Gordon,Alexander V. Chervonsky +12 more
TL;DR: It is found that MyD88 deficiency changes the composition of the distal gut microbiota, and that exposure to the microbiota of specific pathogen-free MyD 88-negative NOD donors attenuates T1D in germ-free NOD recipients.