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K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease

Shaul G. Massry, +80 more
- 01 Oct 2003 - 
- Vol. 42
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This article is published in American Journal of Kidney Diseases.The article was published on 2003-10-01 and is currently open access. It has received 2609 citations till now. The article focuses on the topics: Chronic kidney disease-mineral and bone disorder & Kidney disease.

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Table showing dietary phosphorus/protein ratio for the Spanish population. Usefulness in chronic kidney disease.

TL;DR: The dietary prescription for patients with chronic kidney disease should take into consideration not only the absolute phosphorus value of food consumed, but also the phosphorus to protein ratio of each food and the total amount of phosphorus in the diet.
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The Pathophysiology of Secondary Hyperparathyroidism and the Consequences of Uncontrolled Mineral Metabolism in Chronic Kidney Disease: The Role of COSMOS.

TL;DR: There is an urgent need for new strategies and novel pharmacologic therapies that improve control of mineral metabolism and PTH secretion in SHPT and thus reduce the mortality associated with this condition.
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Sevelamer hydrochloride versus aluminum hydroxide: effect on serum phosphorus and lipids in CAPD patients.

TL;DR: Sevelamer hydrochloride is a well-tolerated alternative to calcium- or aluminum-containing phosphorus binder in the control of serum phosphorus in CAPD patients and improves the lipid profile in these patients.
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Renal Impairment as a Surgical Indication in Primary Hyperparathyroidism: Do the Data Support This Recommendation?

TL;DR: A secondary elevation of PTH levels has not been consistently shown to occur at the threshold currently indicated for surgical intervention, and there is no evidence to suggest that surgically curing primary hyperparathyroidism via a parathyroidectomy has any impact upon renal function.
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A low fractional excretion of Phosphate/Fgf23 ratio is associated with severe abdominal Aortic calcification in stage 3 and 4 kidney disease patients

TL;DR: In CKD 3–4, an impaired phosphaturic response to FGF23 with FEP/FGF23 < 1/3.9 associates with severe AAC independently of age, gender or CP.
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