Open AccessJournal Article
K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease
Shaul G. Massry,Jack W. Coburn,Glenn M. Chertow,Keith A. Hruska,Craig B. Langman,Hartmut H. Malluche,Kevin J. Martin,Linda McCann,James T. McCarthy,Sharon M. Moe,Isidro B. Salusky,Donald J. Sherrand,Miroslaw Smogorzewski,Kline Bolton,Charles Turkelson,Karyn A. Tappe,Stephen Tregear,James Reston,Wendy Bruening,Mark Monteforte,Janice Kaczmarek,Vivian Coates,George R. Bailie,Bryan N. Becker,Gavin J. Becker,Jerrilynn D. Burrowes,Fernando Carrera,David N. Churchill,Allan J. Collins,Peter W. Crooks,Dick DeZeeuw,Thomas A. Golper,Frank A. Gotch,Antonio M. Gotto,Roger Greenwood,Joel W. Greer,Richard H. Grimm,William E. Haley,Ronald J. Hogg,Alan R. Hull,Lawrence G. Hunsicker,Cynda Ann Johnson,Michael J. Klag,Saulo Klahr,Norbert Lameire,Francesco Locatelli,Sally McCulloch,Maureen Michael,Joseph V. Nally,John M. Newmann,Allen R. Nissenson,Keith C. Norris,Gregorio T. Obrador,William F. Owen,Thakor G. Patel,Glenda Payne,Claudio Ronco,Rosa A. Rivera-Mizzoni,Anton C. Schoolwerth,Robert A. Star,Michael W. Steffes,Theodore I. Steinman,John Pierre Wauters,Nanette K. Wenger,Josephine P. Briggs,Thomas H. Hostetter,Garabed Eknoyan,Aderra Levin,Nathan W. Levin,Sharon Andreoli,Sally Burrows-Hudson,Derrick Latos,Donna Mapes,Edith Oberley,Brian J.G. Pereira,Nadine Ferguson,Donna Fingerhut,Anthony Gucciardo,Margaret Klette,Doreen Mallard,Kerry Willis +80 more
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This article is published in American Journal of Kidney Diseases.The article was published on 2003-10-01 and is currently open access. It has received 2609 citations till now. The article focuses on the topics: Chronic kidney disease-mineral and bone disorder & Kidney disease.read more
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Association between 25-hydroxyvitamin D deficiency and cardiovascular disease in type 2 diabetic patients with mild kidney dysfunction
TL;DR: Low serum 25-hydroxyvitamin D concentrations are independently associated with prevalent CVD in type 2 diabetic patients with mild kidney dysfunction and remained statistically significant in participants in the lowest estimated GFR tertile after adjustment for potential confounders.
Journal ArticleDOI
Influence of cholecalciferol supplementation in hemodialysis patients on monocyte subsets: a randomized, double-blind, placebo-controlled clinical trial.
TL;DR: Oral cholecalciferol supplementation according to the K/DOQI recommendations normalizes 25(OH)D levels without relevant side effects such as hyperphosphatemia or hypercalcemia, but beneficial pleiotropic effects on monocyte subset cell counts, T cell differentiation, or cytokine production could not be confirmed at least at the used dosage.
Journal ArticleDOI
Management of secondary hyperparathyroidism in stages 3 and 4 chronic kidney disease.
Dennis L. Andress,Daniel W. Coyne,Kamyar Kalantar-Zadeh,Mark E. Molitch,Farhad Zangeneh,Stuart M. Sprague,Stuart M. Sprague +6 more
TL;DR: approved treatment options for secondary hyperparathyroidism (SHPT) in patients with stages 3 and 4 chronic kidney disease (CKD) are reviewed to review approved treatment options and determine early detection of SHPT is critical for effective treatment.
Journal ArticleDOI
Direct in vitro evidence of the suppressive effect of cinacalcet HCl on parathyroid hormone secretion in human parathyroid cells with pathologically reduced calcium-sensing receptor levels.
Takehisa Kawata,Yasuo Imanishi,Keisuke Kobayashi,Naoyoshi Onoda,Senji Okuno,Yoshiaki Takemoto,Takeshi Komo,Hideki Tahara,Michihito Wada,Nobuo Nagano,Eiji Ishimura,Takami Miki,Tetsuro Ishikawa,Masaaki Inaba,Yoshiki Nishizawa +14 more
TL;DR: Data from this in vitro analysis support the clinical application of cinacalcet in PHPT and SHPT therapy and demonstrates significant potency in the suppression of PTH secretion in primary cultured human parathyroid cells in vitro, despite reduced levels of the target protein, CaR.
Journal ArticleDOI
Vitamin D in patients with renal failure: A summary of observational mortality studies and steps moving forward
Myles Wolf,Ravi Thadhani +1 more
TL;DR: Two recent large-scale studies of hemodialysis patients are examined: one that demonstrated a survival advantage of paricalcitol over calcitriol, and a second that demonstrates a significant survival advantage in any intravenous Vitamin D formulation versus none.
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Cinacalcet for Secondary Hyperparathyroidism in Patients Receiving Hemodialysis
Geoffrey A. Block,Kevin J. Martin,Angel L.M. de Francisco,Stewart A. Turner,Morrell M. Avram,Michael Suranyi,Gavril Hercz,John Cunningham,Ali K. Abu-Alfa,Piergiorgio Messa,Daniel W. Coyne,Francesco Locatelli,Raphael M. Cohen,Pieter Evenepoel,Sharon M. Moe,Albert Fournier,Johann Braun,Laura C. McCary,Valter J. Zani,Kurt Olson,Tilman B. Drüeke,William G. Goodman +21 more
TL;DR: Cinacalcet lowers parathyroid hormone levels and improves calcium-phosphorus homeostasis in patients receiving hemodialysis who have uncontrolled secondary hyperparathyroidism.