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Open AccessJournal Article

K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease

Shaul G. Massry, +80 more
- 01 Oct 2003 - 
- Vol. 42
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This article is published in American Journal of Kidney Diseases.The article was published on 2003-10-01 and is currently open access. It has received 2609 citations till now. The article focuses on the topics: Chronic kidney disease-mineral and bone disorder & Kidney disease.

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Optimizing the dialysate calcium concentration in bicarbonate haemodialysis

TL;DR: While CMB is nearly neutral when using 1.25 DCa, the use of 1.5 DCa results in a gain of Ca during HD, which should be considered in the choice of DCa prescription for HD but need also be weighed against the risk of worse haemodynamic dialysis tolerance.
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Treatment of hyperphosphatemia in patients with chronic kidney disease on maintenance hemodialysis.

TL;DR: Rational guidelines for the use of calcium-based phosphate binders in patients on maintenance hemodialysis are provided and calcium acetate is more efficacious and cost effective than sevelamer, it remains an accepted first-line phosphate binder.
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Vitamin D deficiency is associated with short stature and may influence blood pressure control in paediatric renal transplant recipients

TL;DR: 25(OH)D deficiency is common in pediatric renal transplant recipients and correlates with hyperparathyroidism and short stature and may be a modifiable risk factor for hypertension in transplant recipients.
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The Cost-Effectiveness of Lanthanum Carbonate in the Treatment of Hyperphosphatemia in Patients with End-Stage Renal Disease

TL;DR: Applying a cost-effectiveness threshold of pound30,000 per QALY, the model shows it is cost-effective to follow current treatment guidelines and treat all patients who are not adequately maintained on CC with second-line LC, particularly the case for patients with serum phosphorus above 6.6 mg/dl.
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The demise of calcium-based phosphate binders—is this appropriate for children?

TL;DR: The role of calcium in CKD-MBD is the focus of this review, and clinical and experimental studies have shown that, in the setting of CKD, low serum calcium levels are associated with poor bone mineralisation, whereas high serum calcium Levels can lead to arterial calcification, even in children.
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