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K/DOQI clinical practice guidelines for bone metabolism and disease in chronic kidney disease

Shaul G. Massry, +80 more
- 01 Oct 2003 - 
- Vol. 42
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This article is published in American Journal of Kidney Diseases.The article was published on 2003-10-01 and is currently open access. It has received 2609 citations till now. The article focuses on the topics: Chronic kidney disease-mineral and bone disorder & Kidney disease.

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Chronic renal failure: a neglected comorbidity of COPD

TL;DR: In this paper, the prevalence and correlates of both concealed and overt chronic renal failure in elderly patients with COPD were investigated by logistic regression analysis, and it was shown that overweight and age were significantly associated with both concealed CRF and overt CRF.
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Reduced Production of Creatinine Limits Its Use as Marker of Kidney Injury in Sepsis

TL;DR: In mice, induction of sepsis by cecal ligation and puncture in bilaterally nephrectomized mice increased markers of nonrenal organ injury and serum TNF-alpha, but serum creatinine was significantly lower in septic animals than in animals subjected to bilateral neph rectomy and sham cecals, supporting the need for new biomarkers that provide better measures of renal injury.
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Achieving NKF-K/DOQI™ bone metabolism and disease treatment goals with cinacalcet HCl

TL;DR: In subjects on dialysis with secondary HPT, cinacalcet facilitates achievement of the K/DOQI-recommended targets for PTH, calcium, phosphorus, and Ca x P.
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Fibroblast growth factor 23 is not associated with and does not induce arterial calcification

TL;DR: Whereas elevated phosphate concentrations induced calcification in vitro, FGF23 had no effect on phosphate uptake or phosphate-induced calcification regardless of phosphate concentration or even in the presence of soluble klotho, thus, in contrast to serum phosphate, F GF23 is not associated with arterial calcification and does not promote calcification experimentally.
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High plasma phosphate as a risk factor for decline in renal function and mortality in pre-dialysis patients

TL;DR: High plasma phosphate is an independent risk factor for a more rapid decline in renal function and a higher mortality during the pre- dialysis phase and within the normal range is likely of vital importance in pre-dialysis patients.
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