Journal ArticleDOI
Kisspeptin-10 stimulates the secretion of growth hormone and prolactin directly from cultured bovine anterior pituitary cells.
TLDR
The present study is, as far as the authors know, the first to examine the direct actions of kisspeptin on the secretion of GH and PRL from the bovine pituitary gland.About:
This article is published in Animal Reproduction Science.The article was published on 2008-05-01. It has received 87 citations till now. The article focuses on the topics: Growth hormone secretion & Anterior pituitary.read more
Citations
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Journal ArticleDOI
Kisspeptins and Reproduction: Physiological Roles and Regulatory Mechanisms
TL;DR: This review aims to provide a comprehensive account of the state-of-the-art in the field of kisspeptin physiology by covering in-depth the consensus knowledge on the major molecular features, biological effects, and mechanisms of action ofkisspeptins in mammals and, to a lesser extent, in nonmammalian vertebrates.
Journal ArticleDOI
Bovine C-terminal octapeptide of RFamide-related peptide-3 suppresses luteinizing hormone (LH) secretion from the pituitary as well as pulsatile LH secretion in bovines.
TL;DR: It is suggested that RFRP-3-8 suppresses LH secretion from cultured AP cells, as well as LH pulse frequency in cattle.
Journal ArticleDOI
The neuroanatomy of the kisspeptin system in the mammalian brain.
TL;DR: The available data suggest that kisspeptins are synthesized in neurons in the anteroventral periventricular nucleus and the arcuate nucleus, and both populations are considered to be involved in control of gonadotropes.
Journal ArticleDOI
Comprehensive Review on Kisspeptin and Its Role in Reproductive Disorders
TL;DR: What is known about kisspeptin as a regulator of reproductive function is summarized, an update on recent advances are provided, and a growing body of evidence suggests thatkisspeptin signaling be regulated by nutritional status and stress are summarized.
Journal ArticleDOI
Goldfish kisspeptin: molecular cloning, tissue distribution of transcript expression, and stimulatory effects on prolactin, growth hormone and luteinizing hormone secretion and gene expression via direct actions at the pituitary level.
TL;DR: The results taken together suggest that kisspeptin via Kiss1r activation can act directly at the pituitary level to trigger LH, PRL, and GH secretion and gene expression in goldfish.
References
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Journal ArticleDOI
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Masato Kotani,Michel Detheux,Ann Vandenbogaerde,David Communi,Jean-Marie Vanderwinden,Emmanuel Le Poul,Stéphane Brézillon,Richard Tyldesley,Nathalie Suarez-Huerta,Fabrice Vandeput,Cédric Blanpain,Serge N. Schiffmann,Gilbert Vassart,Marc Parmentier +13 more
TL;DR: Stimulation of oxytocin secretion after kisspeptin administration to rats confirmed this hypothesis that human GPR54 was highly expressed in placenta, pituitary, pancreas, and spinal cord, suggesting a role in the regulation of endocrine function.
Journal ArticleDOI
Direct pituitary effects of kisspeptin: activation of gonadotrophs and somatotrophs and stimulation of luteinising hormone and growth hormone secretion.
Ester Gutiérrez-Pascual,Antonio J. Martínez-Fuentes,Leonor Pinilla,Manuel Tena-Sempere,María M. Malagón,Justo P. Castaño +5 more
TL;DR: Results provide unequivocal evidence that kisspeptins exert direct pituitary effects in peripubertal male and female rats and suggest a possible autocrine/paracrine mode of action.
Journal ArticleDOI
Colocalization of kisspeptin and gonadotropin-releasing hormone in the ovine brain.
TL;DR: The colocalization of GnRH and kisspeptin within cells of the preoptic area and GnRH neurosecretory terminals of the median eminence suggests that the two peptides might be cosecreted into the hypophyseal portal blood to act on the pituitary gland.
Journal ArticleDOI
Kisspepeptin-GPR54 signaling in the neuroendocrine reproductive axis.
TL;DR: A review of what is currently known about kisspeptin-GPR54 signaling in the regulation of the neuroendocrine reproductive axis highlights the importance of this receptor in sexual maturation.
Journal ArticleDOI
Direct kisspeptin-10 stimulation on luteinizing hormone secretion from bovine and porcine anterior pituitary cells.
TL;DR: The present results suggest that kisspeptin-10 has a direct, but weak, stimulating effect on LH secretion in bovine and porcine AP cells.
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