Lack of association between the uncoupling protein-2 Ala55Val gene polymorphism and phenotypic features of the Metabolic Syndrome.
Reads0
Chats0
TLDR
It is concluded that the C-->T substitution in exon 4 of the UCP2 gene does not contribute to the predisposition to be affected by the Metabolic Syndrome.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2002-11-20 and is currently open access. It has received 21 citations till now. The article focuses on the topics: Gene polymorphism & Exon.read more
Citations
More filters
Journal ArticleDOI
The human obesity gene map: the 2003 update.
Eric E. Snyder,Brandon Walts,Louis Pérusse,Yvon C. Chagnon,S. John Weisnagel,Tuomo Rankinen,Claude Bouchard +6 more
TL;DR: This is the tenth update of the human obesity gene map, incorporating published results up to the end of October 2003 and continuing the previous format.
Journal ArticleDOI
Meta-analysis reveals the association of common variants in the uncoupling protein (UCP) 1-3 genes with body mass index variability.
Letícia de Almeida Brondani,Taís Silveira Assmann,Bianca Marmontel de Souza,Ana Paula Bouças,Luis Henrique Santos Canani,Daisy Crispim +5 more
TL;DR: A meta-analysis detected a significant association between the UCP2-866G/A, Ins/Del, Ala55Val and UCP3-55C/T polymorphisms and BMI mean differences.
Journal ArticleDOI
The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications
Bianca Marmontel de Souza,Taís Silveira Assmann,Lucia Maria Kliemann,Jorge Luiz Gross,Luis Henrique Santos Canani,Daisy Crispim +5 more
TL;DR: Uncoupling protein 2 (UCP2) is expressed in several tissues, and acts in the protection against oxidative stress; in the negative regulation of insulin secretion by beta cells, and in fatty acid metabolism, which are associated with DM2 pathogenesis and its chronic complications.
The role of uncoupling protein 2 (UCP2) on the development of type 2 diabetes mellitus and its chronic complications Papel da proteína desacopladora 2 (UCP2) no desenvolvimento do diabetes melito tipo 2 e de suas complicações crônicas
Bianca Marmontel de Souza,Taís Silveira Assmann,Lucia Maria Kliemann,Jorge Luiz Gross,Luis Henrique Santos Canani,Daisy Crispim +5 more
TL;DR: Wang et al. as discussed by the authors have reported that three common polymorphisms in UCP2 gene are possibly associated with type 2 diabetes mellitus and/or obesity, with inconclusive results.
Journal ArticleDOI
Associations between UCP1 -3826A/G, UCP2 -866G/A, Ala55Val and Ins/Del, and UCP3 -55C/T polymorphisms and susceptibility to type 2 diabetes mellitus: case-control study and meta-analysis.
Bianca Marmontel de Souza,Letícia de Almeida Brondani,Ana Paula Bouças,Denise Alves Sortica,Caroline K. Kramer,Luis Henrique Santos Canani,Cristiane Bauermann Leitão,Daisy Crispim +7 more
TL;DR: A case-control study and a meta-analysis were conducted to determine whether the following polymorphisms are associated with type 2 diabetes mellitus and were not able to demonstrate any association; however, a significant association was detected between the UCP2 Ala55Val and UCP3 -55C/T polymorphisms and increased susceptibility for T2DM in Asians.
References
More filters
Journal ArticleDOI
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia
Christophe Fleury,Maria Neverova,Sheila Collins,Serge Raimbault,Odette Champigny,Corinne Levi-Meyrueis,Frédéric Bouillaud,Michael F. Seldin,Richard S. Surwit,Daniel Ricquier,Craig H Warden +10 more
TL;DR: The discovery of a gene that codes for a novel uncoupling protein, designated UCP2, which has 59% amino-acid identity to UCP1, is reported, and properties consistent with a role in diabetes and obesity are described, suggesting that U CP2 has a unique role in energy balance, body weight regulation and thermoregulation and their responses to inflammatory stimuli.
Journal ArticleDOI
Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression
Olivier Boss,Sonia Samec,Ariane Paoloni-Giacobino,Colette Rossier,Abdul G. Dulloo,Josiane Seydoux,Patrick Muzzin,Jean-Paul Giacobino +7 more
TL;DR: The novel UCP3 was 57% and 73% identical to human UCP1 and UCP2, respectively, highly skeletal muscle‐specific and its expression was unaffected by cold acclimation, suggesting this new member of the UCP family is a candidate protein for the modulation of the respiratory control in skeletal muscle.
Journal ArticleDOI
Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production.
Denis Arsenijevic,Hiroki Onuma,Claire Pecqueur,Serge Raimbault,Brian S. Manning,Bruno Miroux,Elodie Couplan,Marie-Clotilde Alves-Guerra,Marc Goubern,Richard S. Surwit,Frédéric Bouillaud,Denis Richard,Sheila Collins,Daniel Ricquier +13 more
TL;DR: It is demonstrated here that mice lacking Ucp2 following targeted gene disruption are not obese and have a normal response to cold exposure or high-fat diet and a role for UCP2 in the limitation of ROS and macrophage-mediated immunity is indicated.
Journal ArticleDOI
Uncoupling Protein-2 Negatively Regulates Insulin Secretion and Is a Major Link between Obesity, β Cell Dysfunction, and Type 2 Diabetes
Chen-Yu Zhang,Gyorgy Baffy,Gyorgy Baffy,Pascale Perret,Stefan Krauss,Odile D. Peroni,Danica Grujic,Thilo Hagen,Antonio Vidal-Puig,Olivier Boss,Young-Bum Kim,Xin Xiao Zheng,Michael B. Wheeler,Gerald I. Shulman,Catherine B. Chan,Bradford B. Lowell +15 more
TL;DR: Results establish UCP2 as a key component of β cell glucose sensing, and as a critical link between obesity, β cell dysfunction, and type 2 diabetes.
Journal ArticleDOI
The Associations between Obesity, Adipose Tissue Distribution and Disease
TL;DR: It was concluded that obesity and abdominal distribution of adipose tissue constitute two separate entities with different pathogenesis, clinical consequences and probably treatment.
Related Papers (5)
Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians
Ken Walder,Rod A. Norman,Robert L. Hanson,Patrick Schrauwen,Maria Neverova,Chris P. Jenkinson,Juliet L. Easlick,Craig H Warden,Claire Pecqueur,Serge Raimbault,Daniel Ricquier,Michael G. Harper,Kristi D. Silver,Alan R. Shuldiner,Gemma Solanes,Bradford B. Lowell,Wendy K. Chung,Rudolph L. Leibel,Richard E. Pratley,Eric Ravussin +19 more