Journal ArticleDOI
Lipid changes of goat sperm plasma membrane during epididymal maturation
TLDR
The altered lipid profile of the mature sperm membrane leads to changes in its fluidity that play an important role in determining the structure and functions of the biomembrane.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 1991-01-30. It has received 76 citations till now. The article focuses on the topics: Sperm plasma membrane & Membrane lipids.read more
Citations
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Journal ArticleDOI
Targeted disruption of hormone-sensitive lipase results in male sterility and adipocyte hypertrophy, but not in obesity
Jun-ichi Osuga,Shun Ishibashi,Teruaki Oka,Hiroaki Yagyu,Ryu-ichi Tozawa,Akihisa Fujimoto,Futoshi Shionoiri,Naoya Yahagi,Frederic B. Kraemer,Osamu Tsutsumi,Nobuhiro Yamada +10 more
TL;DR: It is shown that HSL is required for spermatogenesis but is not the only enzyme that mediates the hydrolysis of triacylglycerol stored in adipocytes, and that adipocytes were significantly enlarged and the size differences between cell and tissue suggests the heterogeneity of adipocytes.
Journal ArticleDOI
Bicarbonate stimulated phospholipid scrambling induces cholesterol redistribution and enables cholesterol depletion in the sperm plasma membrane
Frits M. Flesch,Jos F. Brouwers,Patricia F. E. M. Nievelstein,Arie J. Verkleij,Lambert M.G. van Golde,Ben Colenbrander,Barend M. Gadella +6 more
TL;DR: A model is proposed in which phospholipid scrambling induces the formation of an apical membrane raft in the sperm head surface that enables albumin mediated efflux of cholesterol.
Journal ArticleDOI
A porcine homolog of the major secretory protein of human epididymis, HE1, specifically binds cholesterol.
Naomichi Okamura,Sachiko Kiuchi,Michiko Tamba,Takayuki Kashima,Shinsuke Hiramoto,Tadashi Baba,Françoise Dacheux,Jean-Louis Dacheux,Yoshiki Sugita,Yin-Zhe Jin +9 more
TL;DR: It was found that the He1 homolog is a major cholesterol-binding protein in the porcine epididymal fluid and the possibility that the HE1 homology is involved in the regulation of the lipid composition of the sperm membranes during the maturation in epidIDymis is discussed.
Journal ArticleDOI
The epididymis and sperm maturation: a perspective.
TL;DR: In common mammals, sperm leaving the testis are incapable of fertilizing a female gamete, and when assessing sperm maturation it is necessary to establish the proportion of sperm that has completed and retained all steps of maturation necessary to achieve fertilization of oocytes under the conditions imposed.
References
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Journal ArticleDOI
Alkyl-linked diglycerides inhibit protein kinase C activation by diacylglycerols
Larry W. Daniel,George W. Small,Jeffrey Daniel Schmitt,Canio J. Marasco,Khalid S. Ishaq,Claude Piantadosi +5 more
TL;DR: It is concluded from these studies that the biological activity of alkyl-linked glycerides may be expressed through protein kinase C inhibition.
Journal ArticleDOI
Cell signalling through phospholipid metabolism.
TL;DR: This article deals with a newly discovered transduction mechanism, based on inositol lipids, which is responsible for controlling many aspects of cell function including, it seems, the crucial decision about whether or not to grow.
Journal ArticleDOI
The macromolecular organization of membranes and its bearing on events leading up to fertilization.
TL;DR: The properties of the sperm membrane at different phases of its development up to fertilization are examined in the light of this more general model.
Journal ArticleDOI
The affinity of cholesterol for phosphatidylcholine and sphingomyelin
TL;DR: It was found that the affinity of cholesterol for dipalmitoyl phosphatidylcholine was the same as that for N-palmitsoyl sphingomyelin both at temperatures above and below the gel to liquid crystalline transition temperature of these phospholipids.
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