Journal ArticleDOI
Lipid metabolism and lung cancer.
María Merino Salvador,Marta Gómez de Cedrón,Juan Moreno Rubio,Juan Moreno Rubio,Sandra Falagán Martínez,Ruth Sánchez Martínez,Enrique Casado,Ana Ramírez de Molina,María Sereno +8 more
TLDR
The basis of lipid metabolism in lung cancer is reviewed, potential biomarkers are suggested, and potential therapeutic agents based on bioactive compounds such as cerulenin, SCD1, ACLY inhibitors, statins, polyphenolic compounds, etc.Abstract:
Lung cancer is currently one of the most serious health issues in developed and developing countries. There are multiple available treatment options; however survival still remains very poor. Despite metabolism alteration being one of the hallmarks described in human cancer, lipid metabolism disorders are less known. They are recently becoming more important in this setting and therefore achieving a deeper knowledge might be helpful to obtain new strategies to accurate diagnosis, estimate prognosis, and develop therapeutic agents based on bioactive compounds such as cerulenin, SCD1, ACLY inhibitors, statins, polyphenolic compounds, etc. The present paper reviews the basis of lipid metabolism in lung cancer and suggests potential biomarkers. Further investigation is crucial to improve our knowledge in this area.read more
Citations
More filters
Journal ArticleDOI
Lipid metabolism reprogramming and its potential targets in cancer
TL;DR: SREBP cleavage-activating protein is a key transporter in the trafficking and activation of SREBPs as well as a critical glucose sensor, thus linking glucose metabolism and de novo lipid synthesis and Targeting altered lipid metabolic pathways has become a promising anti-cancer strategy.
Journal ArticleDOI
Alterations of Lipid Metabolism in Cancer: Implications in Prognosis and Treatment.
TL;DR: The impact of obesity and related tumor microenviroment alterations as modifiable risk factors in cancer is analyzed, focusing on the lipid alterations co-occurring during tumorigenesis, and the value of precision technologies and its application to target lipid metabolism in cancer are discussed.
Journal ArticleDOI
YAP and TAZ in Lung Cancer: Oncogenic Role and Clinical Targeting
TL;DR: The most recent advances made in YAP and TAZ biology in lung cancer are discussed and, more importantly, on the newly discovered mechanisms of YAPand TAZ inhibition in lung cancers as well as their clinical implications.
Journal ArticleDOI
Autophagy modulates lipid metabolism to maintain metabolic flexibility for Lkb1-deficient Kras-driven lung tumorigenesis
Vrushank Bhatt,Khoosheh Khayati,Zhixian Sherrie Hu,Amy Lee,Wali Kamran,Xiaoyang Su,Jessie Yanxiang Guo +6 more
TL;DR: It is found that autophagy ablation was synthetically lethal during Lkb1-deficient lung tumorigenesis in both tumor initiation and tumor growth, and this strongly suggest that autophile inhibition could be a strategy for treating LKB1- deficient lung tumors.
Journal ArticleDOI
Lipid metabolism in cancer progression and therapeutic strategies
Yan Fu,Tiantian Zou,Xiao-Tian Shen,Peter J. Nelson,Jiahui Li,Chao Wu,Jimeng Yang,Yan Zheng,Christiane Bruns,Yue Zhao,Lun-Xiu Qin,Qiongzhu Dong +11 more
TL;DR: Recent evidence implicating the contribution of lipid metabolic reprogramming in cancer to cancer progression is reviewed, the molecular mechanisms underlying lipid metabolism rewiring in cancer, and potential therapeutic strategies directed toward lipid metabolism in cancer are discussed.
References
More filters
Journal ArticleDOI
Cancer statistics, 2016
TL;DR: Overall cancer incidence trends are stable in women, but declining by 3.1% per year in men, much of which is because of recent rapid declines in prostate cancer diagnoses, and brain cancer has surpassed leukemia as the leading cause of cancer death among children and adolescents.
Journal ArticleDOI
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial.
Rafael Rosell,Enric Carcereny,Radj Gervais,A. Vergnenegre,Bartomeu Massuti,Enriqueta Felip,Ramon Palmero,Ramon Garcia-Gomez,Cinta Pallares,Jose Miguel Sanchez,Rut Porta,Manuel Cobo,Pilar Garrido,Flavia Longo,Teresa Moran,A. Insa,Filippo de Marinis,Romain Corre,Isabel Bover,Alfonso Illiano,Eric Dansin,Javier de Castro,Michele Milella,Noemi Reguart,Giuseppe Altavilla,Ulpiano Jimenez,Mariano Provencio,Miguel Angel Moreno,J. Terrasa,Jose Muñoz-Langa,Javier Valdivia,Dolores Isla,Manuel Domine,Olivier Molinier,Julien Mazieres,Nathalie Baize,Rosario García-Campelo,Gilles Robinet,Delvys Rodriguez-Abreu,Guillermo Lopez-Vivanco,Vittorio Gebbia,Lioba Ferrera-Delgado,Pierre Bombaron,R. Bernabé,Alessandra Bearz,Angel Artal,Enrico Cortesi,Christian Rolfo,Maria Sanchez-Ronco,Ana Drozdowskyj,Cristina Queralt,Itziar de Aguirre,Jose Luis Ramirez,Jose Javier Sanchez,Miguel Angel Molina,Miquel Taron,Luis Paz-Ares +56 more
TL;DR: Erlotinib has been shown to improve progression-free survival compared with chemotherapy when given as first-line treatment for Asian patients with non-small-cell lung cancer (NSCLC) with activating EGFR mutations as discussed by the authors.
Journal ArticleDOI
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
Andrew G Renehan,Margaret Tyson,Matthias Egger,Matthias Egger,Richard F Heller,Marcel Zwahlen +5 more
TL;DR: Assessment of the strength of associations between BMI and different sites of cancer and differences in these associations between sex and ethnic groups should inform the exploration of biological mechanisms that link obesity with cancer.
Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.
Journal ArticleDOI
Effects of a combination of beta carotene and vitamin a on lung cancer and cardiovascular disease
Gilbert S. Omenn,Gary E. Goodman,Gary E. Goodman,Mark D. Thornquist,John R. Balmes,Mark R. Cullen,Andrew G. Glass,James P. Keogh,Frank L. Meyskens,Barbara Valanis,James H. Williams,Scott Barnhart,Scott Barnhart,Samuel P. Hammar +13 more
TL;DR: After an average of four years of supplementation, the combination of beta carotene and vitamin A had no benefit and may have had an adverse effect on the incidence of lung cancer and on the risk of death from lung cancer, cardiovascular disease, and any cause in smokers and workers exposed to asbestos.