LncRNA-PAGBC acts as a microRNA sponge and promotes gallbladder tumorigenesis.
Xiang Song Wu,Fang Wang,Huai Feng Li,Yun Ping Hu,Lin Jiang,Fei Zhang,Mao Lan Li,Xu-An Wang,Yun Peng Jin,Yi Jian Zhang,Wei Lu,Wen Guang Wu,Yi Jun Shu,Hao Weng,Yang Cao,Run Fa Bao,Hai Bin Liang,Zheng Wang,Yi Chi Zhang,Wei Gong,Lei Zheng,Shu Han Sun,Ying Bin Liu +22 more
TLDR
Functional analysis indicates that lncRNAs in human GBC tissues, including prognosis‐associated gallbladder cancer lncRNA (lncRNA‐PAGBC), are found to be an independent prognostic marker in GBC and provides novel insight on the molecular pathogenesis of GBC.Abstract:
Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis-associated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells. More importantly, as a competitive endogenous RNA (ceRNA), lncRNA-PAGBC competitively binds to the tumour suppressive microRNAs miR-133b and miR-511. This competitive role of lncRNA-PAGBC is required for its ability to promote tumour growth and metastasis and to activate the AKT/mTOR pathway. Moreover, lncRNA-PAGBC interacts with polyadenylate binding protein cytoplasmic 1 (PABPC1) and is stabilized by this interaction. This work provides novel insight on the molecular pathogenesis of GBC.read more
Citations
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A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response
Maite Huarte,Mitchell Guttman,Mitchell Guttman,David M. Feldser,Manuel Garber,Magdalena J. Koziol,Magdalena J. Koziol,Daniela Kenzelmann-Broz,Ahmad M. Khalil,Ahmad M. Khalil,Or Zuk,Ido Amit,Michal Rabani,Laura D. Attardi,Aviv Regev,Aviv Regev,Eric S. Lander,Eric S. Lander,Eric S. Lander,Tyler Jacks,John L. Rinn,John L. Rinn +21 more
TL;DR: In this paper, the identification of lincRNAs (lincRNA-p21) that serve as a repressor in p53-dependent transcriptional responses was reported, and the observed transcriptional repression was mediated through the physical association with hnRNP-K at repressed genes and regulation of p53 mediates apoptosis.
Journal ArticleDOI
LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis
Yiran Liang,Xiaojin Song,Yaming Li,Bing Chen,Wenjing Zhao,Lijuan Wang,Hanwen Zhang,Ying Liu,Dianwen Han,Ning Zhang,Tingting Ma,Yajie Wang,Fangzhou Ye,Dan Luo,Xiaoyan Li,Qifeng Yang +15 more
TL;DR: Results reveal a novel HIF-1α/lnc RNA BCRT1/miR-1303/PTBP3 pathway for breast cancer progression and suggest that lncRNA B CRT1 might be a potential biomarker and therapeutic target for breast cancers.
Journal ArticleDOI
Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer.
Jianan Chen,Yan Yu,Hua Li,Qiuyue Hu,Xiaolong Chen,Yuting He,Chen Xue,Fang Ren,Zhigang Ren,Juan Li,Liwen Liu,Zhenfeng Duan,Guangying Cui,Ranran Sun +13 more
TL;DR: The results of this study reveal a potential ceRNA regulatory pathway in which PVT1 modulates HK2 expression by competitively binding to endogenous miR-143 in GBC cells, which may provide new insights into novel molecular therapeutic targets for GBC.
Journal ArticleDOI
LncRNA PTAR promotes EMT and invasion-metastasis in serous ovarian cancer by competitively binding miR-101-3p to regulate ZEB1 expression
Haihai Liang,Haihai Liang,Tong Yu,Tong Yu,Yue Han,Hua Jiang,Hua Jiang,Chengyu Wang,Tianyi You,Xiaoguang Zhao,Xiaoguang Zhao,Huitong Shan,Huitong Shan,Rui Yang,Rui Yang,Lida Yang,Lida Yang,Hongli Shan,Hongli Shan,Yunyan Gu +19 more
TL;DR: A role for the PTAR-miR-101-ZEB1 axis in OvCa is highlighted, which offers novel strategies for the prevention of metastasis in Ov Ca.
Journal ArticleDOI
SP1-induced lncRNA-ZFAS1 contributes to colorectal cancer progression via the miR-150-5p/VEGFA axis
Xiaoxiang Chen,Kaixuan Zeng,Kaixuan Zeng,Mu Xu,Xiuxiu Hu,Xiuxiu Hu,Xiangxiang Liu,Tao Xu,Bangshun He,Yuqin Pan,Huiling Sun,Shukui Wang +11 more
TL;DR: It is demonstrated that SP1-induced ZFAS1 contributed to CRC progression by upregulating VEG FA via competitively binding to miR-150-5p, which acts as a tumor suppressor by targeting VEGFA in CRC.
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