Journal ArticleDOI
Long-acting nanoparticle-loaded bilayer microneedles for protein delivery to the posterior segment of the eye
Yu Wu,Lalitkumar K. Vora,Yujing Wang,Muhammad Faris Adrianto,Ismaiel Tekko,David Waite,Ryan F. Donnelly,Raghu Raj Singh Thakur +7 more
Reads0
Chats0
TLDR
In this article, a model protein, ovalbumin (OVA)-encapsulated PLGA NPs were prepared and optimized using a water-in-oil-inwater (W/O/W) double emulsion method.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 2021-05-26. It has received 27 citations till now. The article focuses on the topics: Bilayer.read more
Citations
More filters
Journal ArticleDOI
Microneedle scleral patch for minimally invasive delivery of triamcinolone to the posterior segment of eye
TL;DR: In this article , the authors demonstrate the effectiveness of microneedle scleral patch in delivering the model molecule, triamcinolone acetonide, to the posterior segment of the eye.
Journal ArticleDOI
Microneedle scleral patch for minimally invasive delivery of triamcinolone to the posterior segment of eye
TL;DR: In this paper, the authors demonstrate the effectiveness of microneedle scleral patch in delivering the model molecule, triamcinolone acetonide, to the posterior segment of the eye.
Journal ArticleDOI
Nestorone nanosuspension-loaded dissolving microneedles array patch: A promising novel approach for “on-demand” hormonal female-controlled peritcoital contraception
TL;DR: In this article , the authors developed a tip-loaded NES-nanosuspension (NES-NS)-loaded bilayer DMNs to deliver Nestorone intradermally for subsequent release.
Book ChapterDOI
Long-lasting drug delivery systems based on microneedles
TL;DR: In this article, different types of microneedle array patch (MAP)-based self-application technology bypasses many of the challenges associated with injectable routes by delivering the therapeutic materials directly into the intradermal space and allowing the release of the active ingredient in a sustained or controlled manner.
Journal ArticleDOI
Microneedle-based ocular drug delivery systems – recent advances and challenges
Piotr Gadziński,Anna Froelich,Monika Wojtyłko,Antoni Białek,Julia Krysztofiak,Tomasz Osmałek +5 more
TL;DR: This review summarizes the latest achievements in the field of obtaining microneedle ocular patches and discusses the most important advantages and drawbacks related to the unique anatomy and physiology of the eye.
References
More filters
Journal ArticleDOI
Transscleral drug delivery for posterior segment disease.
TL;DR: Recent laboratory and clinical studies that indicate that transscleral delivery of therapeutic solutes might be an effective means of achieving therapeutic concentrations of these agents in the posterior eye are summarized.
Journal ArticleDOI
The effect of a water/organic solvent interface on the structural stability of lysozyme
TL;DR: It is found that emulsification of lysozyme-containing aqueous solutions with methylene chloride causes incomplete protein recovery and non-covalent aggregation of ly sozyme.
Journal ArticleDOI
Microencapsulation of rh-erythropoietin, using biodegradable poly(d,l-lactide-co-glycolide): protein stability and the effects of stabilizing excipients
TL;DR: Using excipients, such as hydroxypropyl-β-cyclodextrin, l -arginine, or bovine serum albumin (BSA), a distinct reduction of the formation of EPO aggregates could be achieved.
Journal ArticleDOI
Two-Photon Excitation Microscopy for the Study of Living Cells and Tissues
TL;DR: The basic physical principles behind two‐photon excitation are described and the advantages and limitations of its use in laser‐scanning microscopy are discussed, including recent technological advances.
Journal ArticleDOI
Preparation and characterization of protein C-loaded PLA nanoparticles.
TL;DR: The obtained results emphasize the potential of protein C-loaded biodegradable nanoparticles for protein progressive delivery in plasma.