Low-density lipoprotein receptor-related protein 1 is a novel modulator of radial glia stem cell proliferation, survival, and differentiation.
Dina Safina,Frederik Schlitt,Ramona Romeo,Thorsten Pflanzner,Claus U. Pietrzik,Vasanthy Narayanaswami,Frank Edenhofer,Andreas Faissner +7 more
TLDR
It is shown that LeX‐glycosylated LRP1 is also expressed in the stem cell compartment of the developing spinal cord and has broader functions in the developing CNS, suggesting that LRP 1 facilitates NSPCs differentiation via interaction with apolipoprotein E (ApoE).Citations
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Single-cell transcriptomic analysis identifies extensive heterogeneity in the cellular composition of mouse Achilles tendons
Andrea J. De Micheli,Andrea J. De Micheli,Jacob B Swanson,Nathaniel P Disser,Leandro M Martinez,Nicholas R Walker,Nicholas R Walker,David Oliver,Benjamin D. Cosgrove,Christopher L. Mendias,Christopher L. Mendias +10 more
TL;DR: A novel and interactive tendon atlas highlights previously underappreciated heterogeneity between and within tendon cell populations, and modeled cell-cell interactions and identified previously undescribed ligand-receptor signaling interactions involved in tendon homeostasis.
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Functional Roles of the Interaction of APP and Lipoprotein Receptors
TL;DR: The molecular mechanisms that are shared by APP and LRPs are reviewed and summarized and their relative contributions to AD are discussed.
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Low Density Receptor-Related Protein 1 Interactions With the Extracellular Matrix: More Than Meets the Eye.
Ewa E. Bres,Andreas Faissner +1 more
TL;DR: This review focuses on the role of Lrp1 and some of its major ligands on ECM function and interactions with two L rp1 ligands, integrins and tissue plasminogen activator are described.
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LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair
TL;DR: These studies reveal a novel role for Lrp1 in peroxisome biogenesis, lipid homeostasis, and OPC differentiation during white matter development and repair.
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Apolipoprotein E Deficiency Exacerbates Spinal Cord Injury in Mice: Inflammatory Response and Oxidative Stress Mediated by NF-κB Signaling Pathway.
Xuan Yang,Shurui Chen,Zhenya Shao,Yuanlong Li,He Wu,Xian Li,Liang Mao,Zipeng Zhou,Liangjie Bai,Xifan Mei,Chang Liu +10 more
TL;DR: Investigation of signaling pathways that regulate Apoe deficiency-dependent inflammatory response and oxidative stress in the acute stage of SCI indicates that a critical role for activation of NF-κB in regulating Apoe-deficiency dependent inflammation and oxidative Stress is detrimental to recovery after SCI.
References
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Adult neurogenesis in the mammalian brain: significant answers and significant questions.
Guo Li Ming,Hongjun Song +1 more
TL;DR: Major advances in understanding of adult mammalian neurogenesis in the dentate gyrus of the hippocampus and from the subventricular zone of the lateral ventricle, the rostral migratory stream to the olfactory bulb are reviewed.
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The glial nature of embryonic and adult neural stem cells
TL;DR: The timing in development and location of NSCs, a property tightly linked to their neuroepithelial origin, appear to be the key determinants of the types of neurons generated.
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The cell biology of neurogenesis.
TL;DR: In this paper, the authors discuss how these features change during development from neuroepithelial to radial glial cells, and how this transition affects cell fate and neurogenesis.
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Clonal and Population Analyses Demonstrate That an EGF-Responsive Mammalian Embryonic CNS Precursor Is a Stem Cell
Brent A. Reynolds,Samuel Weiss +1 more
TL;DR: This study describes the first demonstration, through clonal and population analyses in vitro, of a mammalian CNS stem cell that proliferates in response to an identified growth factor (EGF) and produces the three principal cell types of the CNS.
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Neurogenesis in adult subventricular zone.
TL;DR: This work has identified adult brain regions harboring neural stem cells and their continual generation of new neurons throughout life, an important departure from traditional views of the germinal potential of the postnatal brain.