Journal ArticleDOI
Magnetic resonance angiography of intracranial and extracranial arteries in patients with spontaneous migraine without aura: a cross-sectional study
Faisal Mohammad Amin,Mohammad Sohail Asghar,Anders Hougaard,Adam E. Hansen,Vibeke Andrée Larsen,Patrick J.H. de Koning,Henrik Larsson,Jes Olesen,Messoud Ashina +8 more
Reads0
Chats0
TLDR
Migraine pain was not accompanied by extracranial arterial dilatation, and by only slight intracranial dilated arteries, and future migraine research should focus on the peripheral and central pain pathways rather than simple arterial Dilatation.Abstract:
Summary Background Extracranial arterial dilatation has been hypothesised to be the cause of pain in patients who have migraine without aura. To test that hypothesis, we aimed to measure extracranial and intracranial arteries during attacks of migraine without aura. Methods In this cross-sectional study, we recruited patients aged 18–60 years from the Danish Headache Centre and via announcements on a Danish website. We did magnetic resonance angiography during spontaneous unilateral migraine attacks. Primary endpoints were difference in circumference of extracranial and intracranial arterial segments comparing attack and attack-free days and the pain and the non-pain side. The extracranial arterial segments measured were the external carotid (ECA), the superficial temporal (STA), the middle meningeal (MMA), and the cervical part of the internal carotid (ICA cervical ) arteries. The intracranial arterial segments were the cavernous (ICA cavernous ) and cerebral (ICA cerebral ) parts of the internal carotid, the middle cerebral (MCA), and the basilar (BA) arteries. This study is registered at Clinicaltrials.gov, number NCT01471314. Findings Between Oct 12, 2010, and Feb 8, 2012, we recruited 78 patients, of whom 19 women had a scan during migraine and were included in the final analysis. On migraine compared with non-migraine days, we detected no statistically significant dilatation of the extracranial arteries on the pain side (ECA, mean difference 1·2% [95% CI −5·7 to 8·2] p=0·985, STA 3·6% [–3·7 to 11·0] p=0·532, MMA 1·7% [–1·7 to 5·2] p=0·341, and ICA cervical 2·3% [–0·3 to 4·9] p=0·093); the intracranial arteries were more dilated during attacks (MCA, 13·0% [6·4 to 19·6] p=0·001, ICA cerebral 11·5% [5·6 to 17·3] p=0·0004, and ICA cavernous 11·4% [5·3 to 17·5] p=0·001), except for the BA (1·6% [–2·7 to 5·9] p=0·621). Compared with the non-pain side, during attacks we detected dilatation on the pain side of the intracranial arteries (MCA, mean difference 10·5% [0·7–20·3] p=0·044, ICA cerebral (14·4% [4·6–24·1] p=0·013), and ICA cavernous (9·1% [3·9–14·4] p=0·003) but not of the extracranial arteries (ECA, 2·1% [–3·8 to 9·2] p=0·238, STA, 3·6% [–3·7 to 10·8] p=0·525, MMA, 2·7% [–1·3 to 5·6] p=0·531, and ICA cervical , 5·0% [–0·5 to 10·4] p=0·119). Interpretation Migraine pain was not accompanied by extracranial arterial dilatation, and by only slight intracranial dilatation. Future migraine research should focus on the peripheral and central pain pathways rather than simple arterial dilatation. Funding University of Copenhagen, the Lundbeck Foundation, the Research Foundation of the Capital Region of Denmark, Danish Council for Independent Research-Medical Sciences, and the Novo Nordisk Foundation.read more
Citations
More filters
Journal ArticleDOI
CGRP receptor antagonists and antibodies against CGRP and its receptor in migraine treatment
TL;DR: It is suggested that the antimigraine site should reside in areas not limited by the BBB such as intra- and extracranial vessels, dural mast cells and the trigeminal system, to clarify this topic and surrounding questions.
Journal ArticleDOI
Human models of migraine - short-term pain for long-term gain.
TL;DR: The existing experimental models of migraine in humans, including those that exploit nitric oxide, histamine, neuropeptide and prostaglandin signalling, are summarized and the development and use of these models in the discovery of molecular pathways that are responsible for initiation of migraine attacks are described.
Journal ArticleDOI
A second trigeminal CGRP receptor: function and expression of the AMY1 receptor
Christopher S. Walker,Sajedeh Eftekhari,Rebekah L. Bower,Andrea Wilderman,Paul A. Insel,Lars Edvinsson,Henry J. Waldvogel,Muhammad A. Jamaluddin,Andrew F. Russo,Debbie L. Hay +9 more
TL;DR: This study explores the expression and functionality of two CGRP receptor candidates in the sensory trigeminal system in a condition in need of new treatments.
Journal ArticleDOI
In Vivo Quantification of Calcitonin Gene-Related Peptide Receptor Occupancy by Telcagepant in Rhesus Monkey and Human Brain Using the Positron Emission Tomography Tracer [11C]MK-4232
Eric D. Hostetler,Aniket D. Joshi,Sandra Sanabria-Bohorquez,Hong Fan,Zhizhen Zeng,Mona Purcell,Liza Gantert,Kerry Riffel,Mangay Williams,Stacey O'Malley,Patricia Miller,Harold G. Selnick,Steven N. Gallicchio,Ian M. Bell,Christopher A. Salvatore,Stefanie A. Kane,Chi-Chung Li,Richard Hargreaves,Tjibbe de Groot,Guy Bormans,Anne Van Hecken,Inge Derdelinckx,Jan de Hoon,Tom Reynders,Ruben Declercq,Inge De Lepeleire,William P. Kennedy,Rebecca L. Blanchard,Eugene E. Marcantonio,Cyrille Sur,Jacquelynn J. Cook,Koen Van Laere,Jeffrey L. Evelhoch +32 more
TL;DR: Application of [11C]MK-4232 in human PET studies revealed that telcagepant achieved only low receptor occupancy at an efficacious dose (140 mg PO), therefore, it is unlikely that antagonism of central CGRP-R is required for migraine efficacy.
Journal ArticleDOI
Neurovascular contributions to migraine: Moving beyond vasodilation
Blaine Jacobs,Gregory Dussor +1 more
TL;DR: Together, the data discussed will provide a framework by which vessels can be viewed as important potential contributors to migraine pathophysiology, even in light of the current uncertainty over the role of vasodilation in this disorder.
References
More filters
Journal ArticleDOI
The International Classification of Headache Disorders: 2nd edition
Journal ArticleDOI
Migraine prevalence, disease burden, and the need for preventive therapy
Richard B. Lipton,Marcelo E. Bigal,Merle L. Diamond,Frederick G. Freitag,Michael L. Reed,Walter F. Stewart +5 more
TL;DR: The epidemiologic profile of migraine has remained stable in the United States during the past 15 years and more than one in four migraineurs are candidates for preventive therapy, and a substantial proportion of those who might benefit from prevention do not receive it.
Journal ArticleDOI
Cost of disorders of the brain in Europe 2010
Anders Gustavsson,Mikael Svensson,Frank Jacobi,Christer Allgulander,Jordi Alonso,Ettore Beghi,R. Dodel,Mattias Ekman,Carlo Faravelli,Laura Fratiglioni,Brenda Gannon,David P.H. Jones,Poul Jennum,Albena Jordanova,Linus Jönsson,Korinna Karampampa,Martin Knapp,Martin Knapp,Gisela Kobelt,Tobias Kurth,Roselind Lieb,Mattias Linde,Christina Ljungcrantz,Andreas Maercker,Beatrice Melin,Massimo Moscarelli,Amir Musayev,Fiona Norwood,Martin Preisig,Maura Pugliatti,Juergen Rehm,Luis Salvador-Carulla,Brigitte Schlehofer,Roland Simon,Hans-Christoph Steinhausen,Lars Jacob Stovner,Jean-Michel Vallat,Peter Van den Bergh,Jim van Os,Jim van Os,Pieter E. Vos,Weili Xu,Hans-Ulrich Wittchen,Bengt Jönsson,Jes Olesen +44 more
TL;DR: The present report presents much improved cost estimates for the total cost of disorders of the brain in Europe in 2010, covering 19 major groups of disorders, 7 more than previously, of an increased range of age groups and more cost items.
Journal ArticleDOI
The economic cost of brain disorders in Europe
TL;DR: This new report presents updated, more accurate, and comprehensive 2010 estimates of annual costs for brain disorders in Europe for 30 European countries.
Journal ArticleDOI
Brain stem activation in spontaneous human migraine attacks.
Cornelius Weiller,Arne May,V. Limmroth,M Jüptner,H Kaube,R V Schayck,H H Coenen,Hans-Christoph Diener +7 more
TL;DR: Findings support the idea that the pathogenesis of migraine is related to an imbalance in activity between brain stem nuclei regulating antinociception and vascular control.
Related Papers (5)
The International Classification of Headache Disorders, 3rd edition (beta version)
Jes Olesen,André Bes,Robert S. Kunkel,James W. Lance,Giuseppe Nappi,V Pfaffenrath,Frank Clifford Rose,Bruce S. Schoenberg,D. Soyka,Peer Tfelt-Hansen,K. Michael A. Welch,Marica Wilkinson,Marie-Germaine Bousser,Hans-Christoph Diener,David W. Dodick,Michael First,Peter J. Goadsby,Hartmut Göbel,Miguel J. A. Láinez,Richard B. Lipton,Fumihiko Sakai,Jean Schoenen,Stephen D. Silberstein,Timothy J. Steiner,Lars Bendtsen,Anne Ducros,Stefan Evers,Andrew D. Hershey,Zaza Katsarava,Morris Levin,Julio Pascual,Michael Bjørn Russell,Todd J. Schwedt,Cristina Tassorelli,Gisela M. Terwindt,Maurice Vincent,Shuu Jiun Wang,Andrew Charles,R. Lipton,Hayrunnisa Bolay,Michel Lantéri-Minet,E. A. Macgregor,T. Takeshima,Henrik Winther Schytz,S. Ashina,M. T. Goicochea,K. Hirata,Kenneth A. Holroyd,Christian Lampl,Dimos-Dimitrios Mitsikostas,P. Goadsby,C. Boes,C. Bordini,E. Cittadini,Andrew I. Cohen,M. Leone,A. May,L. Newman,J. Pareja,J. W. Park,T. Rozen,E. Waldenlind,Jong Ling Fuh,Aynur Özge,J. A. Pareja,Mario Fernando Prieto Peres,William B. Young,S. Y. Yu,Ishaq Abu-Arafeh,J. Gladstone,S. J. Huang,Rigmor Jensen,J.M. Láinez,D. Obelieniene,Peter S. Sandor,A. I. Scher,Marcel Arnold,Martin Dichgans,E. Houdart,José M. Ferro,Elizabeth Leroux,Y. S. Li,Aneesh B. Singhal,Gretchen E. Tietjen,Deborah I. Friedman,S. Kirby,B. Mokri,A. Purdy,K. Ravishankar,W. Schievink,R. Stark,F. Taylor,A. V. Krymchantowski,A. Tugrul,N. J. Wiendels,E. Marchioni,V. V. Osipova,Lidia Savi,J. R. Berger,Marcelo E. Bigal,J. González Menacho,Federico Mainardi,J. Pereira-Monteiro,M. Serrano-Dueñas,Roger Cady,C. Fernandez de las Peñas,Vincenzo Guidetti,J. Lance,Peter Svensson,Elizabeth Loder,A. E. Lake,Françoise Radat,J. I. Escobar,R. Benoliel,Claudia Sommer,A. Woda,Joanna M Zakrzewska,V. Aggarwal,L. Bonamico,Dominik A Ettlin,S. Graff-Radford,Jean-Paul Goulet,S. Jääskeläinen,Volker Limmroth,Ambra Michelotti,Donald R. Nixdorf,Mark Obermann,Richard Ohrbach,Paul Pionchon,Tara Renton,S. De Siqueira,Çiçek Wöber-Bingöl +131 more