Neurovascular contributions to migraine: Moving beyond vasodilation
Blaine Jacobs,Gregory Dussor +1 more
TLDR
Together, the data discussed will provide a framework by which vessels can be viewed as important potential contributors to migraine pathophysiology, even in light of the current uncertainty over the role of vasodilation in this disorder.About:
This article is published in Neuroscience.The article was published on 2016-12-03 and is currently open access. It has received 114 citations till now. The article focuses on the topics: Cortical spreading depression & Calcitonin gene-related peptide.read more
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Purinergic Signalling: Therapeutic Developments.
TL;DR: Investigations are in progress for the use of purinergic agents for the treatment of osteoporosis, myocardial infarction, irritable bowel syndrome, epilepsy, atherosclerosis, depression, autism, diabetes, and cancer.
Journal ArticleDOI
Purinergic Signaling in the Cardiovascular System.
TL;DR: The involvement of purinergic signaling in cardiovascular pathophysiology and its therapeutic potential are discussed, including heart failure, infarction, arrhythmias, syncope, cardiomyopathy, angina, heart transplantation and coronary bypass grafts, coronary artery disease, diabetic cardiopathy, hypertension, ischemia, thrombosis, diabetes mellitus, and migraine.
Journal ArticleDOI
Advances in Meningeal Immunity
Rejane Rua,Dorian B. McGavern +1 more
TL;DR: Advances in the understanding of the meningeal immune repertoire are discussed and insights into how this CNS barrier operates immunologically under conditions ranging from neurocognition to inflammatory diseases are provided.
Journal ArticleDOI
Mechanisms of migraine as a chronic evolutive condition
TL;DR: Migraine is a life span neurological disorder that follows an evolutive age-dependent change in its prevalence and even clinical presentations, and genetic and epigenetic factors, inflammatory processes and central sensitization may play an important role.
Journal ArticleDOI
Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models
Amanda Avona,Carolina C. Burgos-Vega,Michael D. Burton,Armen N. Akopian,Theodore J. Price,Gregory Dussor +5 more
TL;DR: The preclinical behavioral models of migraine show that application of calcitonin gene-related peptide (CGRP) to the rat dura mater produces cutaneous periorbital hypersensitivity and the first to demonstrate that CGRP-induced headache-like behavioral responses at doses up to 3.8 μg are female-specific both acutely and following central and peripheral priming.
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The International Classification of Headache Disorders, 3rd edition (beta version)
Jes Olesen,André Bes,Robert S. Kunkel,James W. Lance,Giuseppe Nappi,V Pfaffenrath,Frank Clifford Rose,Bruce S. Schoenberg,D. Soyka,Peer Tfelt-Hansen,K. Michael A. Welch,Marica Wilkinson,Marie-Germaine Bousser,Hans-Christoph Diener,David W. Dodick,Michael First,Peter J. Goadsby,Hartmut Göbel,Miguel J. A. Láinez,Richard B. Lipton,Fumihiko Sakai,Jean Schoenen,Stephen D. Silberstein,Timothy J. Steiner,Lars Bendtsen,Anne Ducros,Stefan Evers,Andrew D. Hershey,Zaza Katsarava,Morris Levin,Julio Pascual,Michael Bjørn Russell,Todd J. Schwedt,Cristina Tassorelli,Gisela M. Terwindt,Maurice Vincent,Shuu Jiun Wang,Andrew Charles,R. Lipton,Hayrunnisa Bolay,Michel Lantéri-Minet,E. A. Macgregor,T. Takeshima,Henrik Winther Schytz,S. Ashina,M. T. Goicochea,K. Hirata,Kenneth A. Holroyd,Christian Lampl,Dimos-Dimitrios Mitsikostas,P. Goadsby,C. Boes,C. Bordini,E. Cittadini,Andrew I. Cohen,M. Leone,A. May,L. Newman,J. Pareja,J. W. Park,T. Rozen,E. Waldenlind,Jong Ling Fuh,Aynur Özge,J. A. Pareja,Mario Fernando Prieto Peres,William B. Young,S. Y. Yu,Ishaq Abu-Arafeh,J. Gladstone,S. J. Huang,Rigmor Jensen,J.M. Láinez,D. Obelieniene,Peter S. Sandor,A. I. Scher,Marcel Arnold,Martin Dichgans,E. Houdart,José M. Ferro,Elizabeth Leroux,Y. S. Li,Aneesh B. Singhal,Gretchen E. Tietjen,Deborah I. Friedman,S. Kirby,B. Mokri,A. Purdy,K. Ravishankar,W. Schievink,R. Stark,F. Taylor,A. V. Krymchantowski,A. Tugrul,N. J. Wiendels,E. Marchioni,V. V. Osipova,Lidia Savi,J. R. Berger,Marcelo E. Bigal,J. González Menacho,Federico Mainardi,J. Pereira-Monteiro,M. Serrano-Dueñas,Roger Cady,C. Fernandez de las Peñas,Vincenzo Guidetti,J. Lance,Peter Svensson,Elizabeth Loder,A. E. Lake,Françoise Radat,J. I. Escobar,R. Benoliel,Claudia Sommer,A. Woda,Joanna M Zakrzewska,V. Aggarwal,L. Bonamico,Dominik A Ettlin,S. Graff-Radford,Jean-Paul Goulet,S. Jääskeläinen,Volker Limmroth,Ambra Michelotti,Donald R. Nixdorf,Mark Obermann,Richard Ohrbach,Paul Pionchon,Tara Renton,S. De Siqueira,Çiçek Wöber-Bingöl +131 more
TL;DR: The International Classification of Headache Disorders, 3 edition (beta version), may be reproduced freely for scientific, educational or clinical uses by institutions, societies or individuals as mentioned in this paper. But the authors require the permission of the International Headache Society.
Journal ArticleDOI
The International Classification of Headache Disorders
TL;DR: The ICHD identifies and categorizes more than a hundred different kinds of headache in a logical, hierarchal system and has provided explicit diagnostic criteria for all of the headache disorders listed.
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Vascular endothelial cells synthesize nitric oxide from L-arginine.
TL;DR: It is demonstrated that NO can be synthesized from L-arginine by porcine aortic endothelial cells in culture and the strict substrate specificity of this reaction suggests that L- arginine is the precursor for NO synthesis in vascular endothelium cells.
Journal ArticleDOI
Spreading depression of activity in the cerebral cortex
TL;DR: In this article, an interesting response elicited by electrical stimulation was noticed in the cortex of rabbits, and the distinctive feature of this response was a marked, enduring reduction of the "spontaneous" electrical activity of the cortex.
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