Management of the corpse with suspect, probable or confirmed COVID-19 respiratory infection - Italian interim recommendations for personnel potentially exposed to material from corpses, including body fluids, in morgue structures and during autopsy practice.
Vittorio Fineschi,Anna Aprile,Isabella Aquila,Mauro Arcangeli,Alessio Asmundo,Mauro Bacci,Mariano Cingolani,Luigi Cipolloni,Stefano D'Errico,Ilaria de Casamassimi,Giulio Di Mizio,Marco Di Paolo,Martina Focardi,Paola Frati,Mario Gabbrielli,Raffaele La Russa,Aniello Maiese,Federico Manetti,Massimo Martelloni,E. Mazzeo,Angelo Montana,Margherita Neri,Martina Padovano,Vilma Pinchi,Cristoforo Pomara,Pietrantonio Ricci,Monica Salerno,Alessandro Santurro,Matteo Scopetti,Roberto Testi,Emanuela Turillazzi,Giuseppe Vacchiano,Filippo Crivelli,Emanuela Bonoldi,Fabio Facchetti,Manuela Nebuloni,Anna Sapino +36 more
TLDR
This document is produced with the intent of offering a technical support to professional involved in the autoptic activities during the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) epidemic infection.Abstract:
The COVID-19 (Coronavirus Disease-19) is the most urgent health emergency worldwide and all professionals are called to give support in the diagnosis and treatment of patients affected by this disease. The Scientific Society of Hospital Legal Medicine of the National Health System (COMLAS) and the Italian Society of Anatomical Pathology and Cytology (SIAPEC) produced this document with the intent of offering a technical support to professional involved in the autoptic activities during the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) epidemic infection.read more
Citations
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Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study.
Luca Carsana,Aurelio Sonzogni,Ahmed Nasr,Roberta Simona Rossi,Alessandro Pellegrinelli,Pietro Zerbi,Roberto Rech,Riccardo Colombo,Spinello Antinori,Mario Corbellino,Massimo Galli,Emanuele Catena,Antonella Tosoni,Andrea Gianatti,Manuela Nebuloni +14 more
TL;DR: The predominant pattern of lung lesions in patients with COVID-19 patients is diffuse alveolar damage, as described in patients infected with severe acute respiratory syndrome and Middle East respiratory syndrome coronaviruses.
Journal ArticleDOI
Pulmonary pathology and COVID-19: lessons from autopsy. The experience of European Pulmonary Pathologists.
Fiorella Calabrese,Federica Pezzuto,Francesco Fortarezza,Paul Hofman,Izidor Kern,Angel Panizo,Jan H. von der Thüsen,Sergei Timofeev,Gregor Gorkiewicz,Francesca Lunardi +9 more
TL;DR: The first evidence of diffuse alveolar damage in the context of an acute respiratory distress syndrome has now been joined by the latest findings that report a more complex scenario in COVID-19, including a vascular involvement and a wide spectrum of associated pathologies.
Journal ArticleDOI
Autopsy findings in COVID-19-related deaths: a literature review
Aniello Maiese,Alice Chiara Manetti,Raffaele La Russa,Marco Di Paolo,Emanuela Turillazzi,Paola Frati,Vittorio Fineschi +6 more
TL;DR: It appears that there is a high incidence of deep vein thrombosis and pulmonary embolism among COVID-19 decedents, suggesting endothelial involvement, but more studies are needed.
Journal ArticleDOI
A review of the main histopathological findings in coronavirus disease 2019.
Walter Oqueli Vasquez-Bonilla,Roberto Orozco,Victor Argueta,Manuel Sierra,Lysien I. Zambrano,Fausto Muñoz-Lara,Dennis Salomón López-Molina,Kovy Arteaga-Livias,Zachary Grimes,Clare Bryce,Alberto Paniz-Mondolfi,Alfonso J. Rodriguez-Morales +11 more
TL;DR: A systematic meta-analysis of histopathologic observations to date is conducted and the reported findings are reviewed to gain a better understanding of disease pathophysiology and its ongoing impact on public health.
Journal ArticleDOI
Postmortem Findings Associated With SARS-CoV-2: Systematic Review and Meta-analysis.
Swati Satturwar,Mary Fowkes,Carol Farver,Allecia M. Wilson,Albino Eccher,Ilaria Girolami,Elisabet Pujadas,Clare Bryce,Fadi Salem,Siraj M. El Jamal,Alberto Paniz-Mondolfi,Bruce Petersen,Ronald E. Gordon,Jason Reidy,Filippo Fraggetta,Desiree A. Marshall,Liron Pantanowitz +16 more
TL;DR: In this paper, the authors systematically summarize the rapidly emerging literature regarding COVID-19 autopsies and conduct a meta-analysis based on data accrued from preprint and published articles.
References
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Victor M. Corman,Olfert Landt,Marco Kaiser,Richard Molenkamp,Adam Meijer,Daniel K.W. Chu,Tobias Bleicker,Sebastian Brünink,Julia Schneider,Marie Luisa Schmidt,Daphne G.J.C. Mulders,Bart L. Haagmans,Bas van der Veer,Sharon van den Brink,Lisa Wijsman,Gabriel Goderski,Jean Louis Romette,Joanna Ellis,Maria Zambon,Malik Peiris,Herman Goossens,Chantal B.E.M. Reusken,Marion Koopmans,Christian Drosten +23 more
TL;DR: A validated diagnostic workflow for 2019-nCoV is presented, its design relying on close genetic relatedness of 2019- nCoV with SARS coronavirus, making use of synthetic nucleic acid technology.
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