Maternally expressed gene 3 (MEG3): A tumor suppressor long non coding RNA
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TLDR
Several aspects of the participation of MEG3 in carcinogenesis are discussed, and this lncRNA is regarded as a putative cancer biomarker and treatment target.About:
This article is published in Biomedicine & Pharmacotherapy.The article was published on 2019-10-01 and is currently open access. It has received 110 citations till now. The article focuses on the topics: Carcinogenesis & MEG3.read more
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LncRNA LINC00470 promotes the degradation of PTEN mRNA to facilitate malignant behavior in gastric cancer cells.
TL;DR: It is shown that LINC00470 was significantly upregulated in GC tissues and cell lines, and correlated with distant metastasis, TNM stage and poor prognosis, and might serve as a therapeutic target for GC patients.
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CircRNAs in anticancer drug resistance: recent advances and future potential
TL;DR: This review is the first to summarize the latest research on circRNAs in anticancer drug resistance based on drug classification and to discuss their potential clinical applications.
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Exosomal Long Non-Coding RNAs in Lung Diseases.
Christophe Poulet,Makon-Sébastien Njock,Catherine Moermans,Edouard Louis,Renaud Louis,Michel Malaise,Julien Guiot +6 more
TL;DR: The need for additional studies describing the lncRNA mechanisms of action and confirming their potential as biomarkers, as well as their involvement in resistance to treatment, especially in non-cancerous lung diseases is concluded.
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Emerging roles of long noncoding RNAs in chemoresistance of pancreatic cancer
TL;DR: A number of compounds are described, including curcumin, genistein, resveratrol, quercetin, and salinomycin, which may modulate the expression of lncRNAs and enhance chemosensitivity in pancreatic cancers.
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Long non-coding RNAs and pyroptosis.
TL;DR: The role of lncRNAs in regulating pyroptosis is reviewed, aiming to provide new ideas for the research of lNCRNAs regulating pyrptosis and treating pyroPTosis-related diseases.
References
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Snail, ZEB and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
TL;DR: The identification of Snail, ZEB and some basic helix-loop-helix factors as inducers of epithelial–mesenchymal transition (EMT) and potent repressors of E-cadherin expression has opened new avenues of research with potential clinical implications.
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MEG3 noncoding RNA: a tumor suppressor
TL;DR: Evidence is presented that inactivation of Meg3 leads to a significant increase in expression of angiogenesis-promoting genes and microvessel formation in the brain, suggesting that MEG3 functions as a novel lncRNA tumor suppressor.
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Activation of p53 by MEG3 non-coding RNA.
Yunli Zhou,Ying Zhong,Yingying Wang,Xun Zhang,Dalia L. Batista,Roger Gejman,Peter J. Ansell,Jing Zhao,Catherine Weng,Anne Klibanski +9 more
TL;DR: It is found that transfection of expression constructs for MEG3 and its isoforms results in a significant increase in p53 protein levels and dramatically stimulates p 53-dependent transcription from a p53-responsive promoter, supporting the concept that M EG3 functions as a non-coding RNA.
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MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA–DNA triplex structures
Tanmoy Mondal,Santhilal Subhash,Roshan Vaid,Stefan Enroth,Sireesha Uday,Björn Reinius,Sanhita Mitra,Arif Mohammed,Alva Rani James,Emily Hoberg,Aristidis Moustakas,Ulf Gyllensten,Steven J.M. Jones,Claes M. Gustafsson,Andrew H. Sims,Fredrik Westerlund,Eduardo Gorab,Chandrasekhar Kanduri +17 more
TL;DR: It is shown that MEG3 and EZH2 share common target genes, including the TGF-β pathway genes, and RNA–DNA triplex formation could be a general characteristic of target gene recognition by the chromatin-interacting lncRNAs.
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Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression
Kaihua Lu,Kaihua Lu,Wei Li,Xiang-hua Liu,Ming Sun,Meiling Zhang,Wei-qin Wu,Wei-ping Xie,Ya-yi Hou +8 more
TL;DR: MEG3 expression was decreased in non-small cell lung cancer (NSCLC) tumor tissues compared with normal tissues, and associated with advanced pathologic stage, and tumor size, which indicates that MEG3 may represent a new marker of poor prognosis and is a potential therapeutic target for NSCLC intervention.