Journal ArticleDOI
MDM4 overexpression contributes to synoviocyte proliferation in patients with rheumatoid arthritis.
Nanwei Xu,Yuji Wang,Yuji Wang,Dawei Li,Guo-Qiang Chen,Rongbin Sun,Ruixia Zhu,Sai Sun,Hongwei Liu,Guang Yang,Tianhua Dong +10 more
TLDR
It is suggested that the abundant expression of MDM4 in FLS may contribute to the hyperplasia phenotype of RA synovial tissues.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 2010-10-22. It has received 8 citations till now. The article focuses on the topics: Synoviocyte proliferation & Arthritis.read more
Citations
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An RNA‐seq protocol to identify mRNA expression changes in mouse diaphyseal bone: Applications in mice with bone property altering Lrp5 mutations
Ugur M. Ayturk,Christina Jacobsen,Danos C. Christodoulou,Joshua M. Gorham,Jonathan G. Seidman,Christine E. Seidman,Alexander G. Robling,Matthew L. Warman +7 more
TL;DR: It is concluded that reliable and reproducible RNA‐seq data can be obtained from mouse diaphyseal bone and that lack of LRP5 has a more pronounced effect on gene expression than the HBM‐causing L RP5 missense mutation.
Journal ArticleDOI
Targeting MDM2 for novel molecular therapy: Beyond oncology
TL;DR: Recent findings related to the roles of MDM2 in the pathogenesis of several nonmalignant diseases, the therapeutic potential of its downregulation or inhibition, and its use as a biomarker are paid special attention.
Journal ArticleDOI
NEU3 inhibitory effect of naringin suppresses cancer cell growth by attenuation of EGFR signaling through GM3 ganglioside accumulation.
Ayana Yoshinaga,Natsuki Kajiya,Kazuki Oishi,Yuko Kamada,Asami Ikeda,Petros Kingstone Chigwechokha,Toshiro Kibe,Michiko Kishida,Shosei Kishida,Masaharu Komatsu,Kazuhiro Shiozaki +10 more
TL;DR: A novel mechanism of naringin is suggested in the suppression of cancer cell growth through the alteration of glycolipids through the inhibition of NEU3 sialidase.
Journal ArticleDOI
MicroRNA‑34a‑3p inhibits proliferation of rheumatoid arthritis fibroblast‑like synoviocytes
TL;DR: The results of the present study indicated that miR-34a-3p may be considered a promising therapeutic target for RA through inhibiting FLS proliferation and suppressing the production of pro-inflammatory cytokines and MMPs.
Journal ArticleDOI
Paeoniflorin Suppresses Rheumatoid Arthritis Development via Modulating the Circ-FAM120A/miR-671-5p/MDM4 Axis.
Junfu Ma,Qingliang Meng,Junping Zhan,Huilian Wang,Fan Wei,Yanqi Wang,Sudan Zhang,Hua Bian,Fuzeng Zheng +8 more
TL;DR: Paeoniflorin is an active ingredient derived from Paeonia, which has an anti-inflammatory effect as discussed by the authors, which has been shown to restrain proliferation, migration, invasion, and inflammation and accelerated cell cycle arrest in RA fibroblast-like synoviocytes (RA-FLSs).
References
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Journal ArticleDOI
The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.
Frank C. Arnett,Steven M. Edworthy,Daniel A. Bloch,Dennis J. McShane,James F. Fries,Norman S. Cooper,L. A. Healey,Stephen R. Kaplan,Matthew H. Liang,Harvinder S. Luthra,Thomas A. Medsger,Donald M. Mitchell,David H. Neustadt,Robert S. Pinals,Jane G. Schaller,John T. Sharp,Ronald L. Wilder,Gene G. Hunder +17 more
TL;DR: The revised criteria for the classification of rheumatoid arthritis (RA) were formulated from a computerized analysis of 262 contemporary, consecutively studied patients with RA and 262 control subjects with rheumatic diseases other than RA (non-RA).
Journal ArticleDOI
Surfing the p53 network
TL;DR: The p53 tumour-suppressor gene integrates numerous signals that control cell life and death, and the disruption of p53 has severe consequences when a highly connected node in the Internet breaks down.
Journal ArticleDOI
Modes of p53 regulation.
Jan Philipp Kruse,Wei Gu +1 more
TL;DR: It is proposed that antirepression, the release of p53 from repression by factors such as Mdm2 and MdmX, is a key step in the physiological activation of p 53.
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Rescue of embryonic lethality in Mdm4 -null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
John M. Parant,Arturo Chavez-Reyes,Arturo Chavez-Reyes,Natalie A. Little,Wen Yan,Valerie Reinke,Aart G. Jochemsen,Guillermina Lozano +7 more
TL;DR: MDM2 and MDM4 are nonoverlapping critical regulators of p53 in vivo, which define a new pathway of p 53 regulation and raise the possibility that increasedMDM4 levels and the resulting inactivation of p52 contribute to the development of human tumors.
Journal ArticleDOI
Inhibition of Metastatic Outgrowth from Single Dormant Tumor Cells by Targeting the Cytoskeleton
Dalit Barkan,Hynda K. Kleinman,Justin L. Simmons,Holly Asmussen,Anil K. Kamaraju,Mark J. Hoenorhoff,Zi-yao Liu,Sylvain V. Costes,Edward H. Cho,Stephen J. Lockett,Chand Khanna,Ann F. Chambers,Jeffrey E. Green +12 more
TL;DR: In vitro growth characteristics of cells that exhibit either dormant or proliferative metastatic behavior in vivo are characterized and phosphorylation of myosin light chain by MLC kinase (MLCK) through integrin beta1 is required for actin stress fiber formation and proliferative growth.