Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells
Myung Soo Kim,Matthew J. Haney,Yuling Zhao,Vivek Mahajan,I.M. Deygen,Natalia L. Klyachko,Natalia L. Klyachko,Eli Inskoe,Aleksandr Piroyan,Marina Sokolsky,Onyi Okolie,Shawn Hingtgen,Alexander V. Kabanov,Alexander V. Kabanov,Elena V. Batrakova +14 more
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TLDR
A exosome-based system to carry formulation of PTX was developed and showed efficacy in the treatment of multi-drug resistant cancer cells and this novel system may be further developed to carry other chemotherapeutic agents in the future.About:
This article is published in Nanomedicine: Nanotechnology, Biology and Medicine.The article was published on 2016-04-01 and is currently open access. It has received 877 citations till now. The article focuses on the topics: Exosome & Drug delivery.read more
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The biology, function, and biomedical applications of exosomes
TL;DR: The intrinsic properties of exosomes in regulating complex intracellular pathways has advanced their potential utility in the therapeutic control of many diseases, including neurodegenerative conditions and cancer.
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Extracellular vesicles in cancer - implications for future improvements in cancer care.
TL;DR: A review of the biophysical properties and physiological functions of extracellular vesicles, particularly their pro-metastatic effects, and highlight the utility of EVs for the development of cancer diagnostics and therapeutics can be found in this paper.
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Extracellular vesicles for drug delivery.
TL;DR: Recent progress and remaining challenges in the development of EVs as drug delivery vehicles are reviewed and discussed.
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Engineering exosomes as refined biological nanoplatforms for drug delivery.
TL;DR: Exosomes, a subgroup of extracellular vesicles (EVs), have been recognized as important mediators of long distance intercellular communication and are involved in a diverse range of biological processes as mentioned in this paper.
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Review of the Isolation, Characterization, Biological Function, and Multifarious Therapeutic Approaches of Exosomes
TL;DR: The history, biogenesis, release, isolation, characterization, and biological functions of exosomes, as well as the factors influencing their biogenesis and their technical and biological challenges are discussed.
References
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Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
TL;DR: This unit describes different approaches for exosome purification from various sources, and discusses methods to evaluate the purity and homogeneity of the purified exosomes preparations.
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Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
TL;DR: It is shown that exosomes—endogenous nano-vesicles that transport RNAs and proteins—can deliver short interfering (si)RNA to the brain in mice, and the therapeutic potential of exosome-mediated siRNA delivery was demonstrated by the strong mRNA and protein knockdown of BACE1, a therapeutic target in Alzheimer's disease, in wild-type mice.
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Membrane vesicles as conveyors of immune responses
TL;DR: The role of membrane vesicles, in particular exosomes, in the communication between immune cells, and between tumour and immune cells is focused on.
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Drug delivery and nanoparticles:applications and hazards
Wim H. de Jong,Paul J A Borm +1 more
TL;DR: An overview on some of the currently used systems for drug delivery, varying from biological substances like albumin, gelatine and phospholipids for liposomes, and more substances of a chemical nature like various polymers and solid metal containing nanoparticles is provided.
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Exosomes: extracellular organelles important in intercellular communication.
TL;DR: This review focuses on various strategies for purifying exosomes and discusses their biophysical and biochemical properties, and an update on proteomic analysis of exosome from various cell types and body fluids is provided and host-cell specific proteomic signatures are discussed.