Journal ArticleDOI
Mitochondrial complex I deficiency in Parkinson's disease.
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This article is published in The Lancet.The article was published on 1989-06-03. It has received 1548 citations till now. The article focuses on the topics: NAD(P)H Dehydrogenase (Quinone) & Substantia nigra.read more
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Levodopa in the treatment of Parkinson's disease.
TL;DR: Maintaining good motor function and quality of life remain the primary goals of therapy and the principle that treatment must be tailored to the individual patient’s needs is paramount.
Journal ArticleDOI
The effects of environmental neurotoxicants on the dopaminergic system: A possible role in drug addiction.
Douglas C. Jones,Gary W. Miller +1 more
TL;DR: The recent hypothesis that exposure to environmental compounds which have effects on dopaminergic neurotransmission, including 2,4-dichlorophenoxyacetic acid, Bisphenol A, and multiple heavy metals, may potentiate drug-induced behaviors and increase the brain's vulnerability to drug addiction will be discussed.
Journal ArticleDOI
Mono- and double-mutant mouse models of Parkinson's disease display severe mitochondrial damage
Christine C. Stichel,Xin-Ran Zhu,Verian Bader,Bettina Linnartz,Saskia Schmidt,Hermann Lübbert +5 more
TL;DR: Together these results provide compelling evidence that both, asyn and parkin are relevant for mitochondrial integrity, the influence of these proteins on mitochondria are age- and tissue-specific and changes of mitochondrial morphology do not inevitably cause functional impairments.
Journal ArticleDOI
Mitochondrial respiratory failure in skeletal muscle from patients with Parkinson's disease and multiple system atrophy.
Olivier Blin,Claude Desnuelle,Olivier Rascol,M. Borg,H.Peyro Saint Paul,Jean-Philippe Azulay,F. Billé,D. Figarella,F. Coulom,Jean-François Pellissier,Jean-Louis Montastruc,M. Chatel,Georges Serratrice +12 more
TL;DR: The hypothesis of a wide-spread mitochondrial complex I deficiency in PD and MSA as compared to age-matched controls is supported, which can be found in de novo PD patients as well as in treated patients.
Journal ArticleDOI
Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance
Bavo Heeman,Chris Van den Haute,Sarah-Ann Aelvoet,Federica Valsecchi,Richard J. Rodenburg,Veerle Reumers,Zeger Debyser,Geert Callewaert,Werner J.H. Koopman,Peter H.G.M. Willems,Veerle Baekelandt +10 more
TL;DR: A key role for PINK1 is demonstrated in the regulation of mitochondrial homeostasis and energy metabolism under physiological conditions, and the impairment in energy maintenance was confirmed in the brain of Pink1-knockout mice by in vivo bioluminescence imaging.
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