Journal ArticleDOI
Mitochondrial complex I deficiency in Parkinson's disease.
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This article is published in The Lancet.The article was published on 1989-06-03. It has received 1548 citations till now. The article focuses on the topics: NAD(P)H Dehydrogenase (Quinone) & Substantia nigra.read more
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Journal ArticleDOI
Mitochondrial Dysfunction in Parkinson's Disease-Cause or Consequence?
TL;DR: Whether the mitochondrial dysfunction the authors have detected in Parkinson’s disease is a pathogenic cause of neuronal loss or whether it is itself a consequence of dysfunction in other pathways is discussed.
Journal ArticleDOI
Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells.
TL;DR: The results suggest that under overexpression conditions, alpha-syn may translocate to mitochondria and cause enhanced toxicity in response to sub toxic concentrations of mitochondrial toxins.
Journal ArticleDOI
Parkinson's disease and cancer: two wars, one front
TL;DR: How insights from one disease can inform us about, and possibly help us to treat, the other is discussed and areas of convergence are considered.
Journal ArticleDOI
The mitochondrial protein BNIP3L is the substrate of PARK2 and mediates mitophagy in PINK1/PARK2 pathway
TL;DR: It is demonstrated that BNIP3L, as a substrate of PARK2, promotes mitophagy in the PINK1/PARK2 pathway associated with PD pathogenesis.
Journal ArticleDOI
Use of Transmitochondrial Cybrids To Assign a Complex I Defect to the Mitochondrial DNA-Encoded NADH Dehydrogenase Subunit 6 Gene Mutation at Nucleotide Pair 14459 That Causes Leber Hereditary Optic Neuropathy and Dystonia
TL;DR: Observations suggest that the ND6 np 14459 mutation may alter the coenzyme Q-binding site of complex I, which is the cause of Leber hereditary optic neuropathy and/or pediatric-onset dystonia in three unrelated families.
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