Journal ArticleDOI
Mitochondrial complex I deficiency in Parkinson's disease.
Reads0
Chats0
About:
This article is published in The Lancet.The article was published on 1989-06-03. It has received 1548 citations till now. The article focuses on the topics: NAD(P)H Dehydrogenase (Quinone) & Substantia nigra.read more
Citations
More filters
Journal ArticleDOI
Somatic mitochondrial DNA mutations in early Parkinson and incidental Lewy body disease.
Michael T. Lin,Ippolita Cantuti-Castelvetri,Kangni Zheng,Katie E. Jackson,Yong B. Tan,Thomas Arzberger,Andrew J. Lees,Rebecca A. Betensky,M. Flint Beal,David Simon +9 more
TL;DR: It is shown for the first time that mtDNA mutation levels in substantia nigra neurons are significantly elevated in this group of early PD and ILBD cases.
Journal ArticleDOI
PGC-1α at the intersection of bioenergetics regulation and neuron function: from Huntington's disease to Parkinson's disease and beyond
Taiji Tsunemi,Albert R. La Spada +1 more
TL;DR: The role of PGC-1α in normal nervous system function and potentially neurological disease has been investigated in this article, where the role of PPARγ co-activator was shown to contribute to the development of Parkinson's disease.
Journal ArticleDOI
The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis.
Michael L.-H. Huang,Shannon Chiang,Danuta S. Kalinowski,Dong-Hun Bae,Sumit Sahni,Des R. Richardson +5 more
TL;DR: The pathological involvement of mitochondrial dysfunction in relation to oxidative stress, energy metabolism, mitochondrial dynamics, and cell death will be explored and offers potential therapeutic targets in the development of future treatments for these degenerative diseases.
Journal ArticleDOI
Therapeutic potential of N-acetylcysteine in age-related mitochondrial neurodegenerative diseases.
TL;DR: The mechanisms of N-acetylcysteine action at the cellular level, and the possible usefulness of this antioxidant for the treatment of age-associated neurodegenerative diseases are reviewed.
Journal ArticleDOI
Partial Mitochondrial Inhibition Causes Striatal Dopamine Release Suppression and Medium Spiny Neuron Depolarization via H2O2 Elevation, Not ATP Depletion
TL;DR: It is shown that acute exposure to the mitochondrial complex I inhibitor rotenone causes concentration-dependent suppression of single-pulse evoked dopamine release monitored in real time with carbon-fiber microelectrodes in guinea pig striatal slices, with no effect on DA content.
Related Papers (5)
Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis
Mutation in the α-synuclein gene identified in families with Parkinson's disease
Mihael H. Polymeropoulos,Christian Lavedan,Elisabeth Leroy,Susan E. Ide,Anindya Dehejia,Amalia Dutra,Brian L. Pike,Holly Root,Jeffrey Rubenstein,Rebecca Boyer,Edward S. Stenroos,Settara C. Chandrasekharappa,Aglaia Athanassiadou,Theodore Papapetropoulos,William G. Johnson,Alice Lazzarini,Roger C. Duvoisin,Giuseppe Di Iorio,Lawrence I. Golbe,Robert L. Nussbaum +19 more
Hereditary Early-Onset Parkinson's Disease Caused by Mutations in PINK1
Eriza Maria Valente,Patrick M. Abou-Sleiman,Viviana Caputo,Miratul M. K. Muqit,Kirsten Harvey,Suzana Gispert,Zeeshan Ali,Domenico Del Turco,Anna Rita Bentivoglio,Daniel G. Healy,Alberto Albanese,Robert L. Nussbaum,Rafael González-Maldonado,Thomas Deller,S Salvi,Pietro Cortelli,William P. Gilks,David S. Latchman,Roberk J. Harvey,Bruno Dallapiccola,Georg Auburger,Nicholas W. Wood +21 more