Journal ArticleDOI
Mitochondrial complex I deficiency in Parkinson's disease.
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This article is published in The Lancet.The article was published on 1989-06-03. It has received 1548 citations till now. The article focuses on the topics: NAD(P)H Dehydrogenase (Quinone) & Substantia nigra.read more
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Understanding the Multiple Role of Mitochondria in Parkinson's Disease and Related Disorders: Lesson From Genetics and Protein-Interaction Network.
Valentina Nicoletti,Giovanni Palermo,Eleonora Del Prete,Michelangelo Mancuso,Roberto Ceravolo +4 more
TL;DR: In this paper, the authors summarize and discuss the deep interconnections between mitochondrial dysfunction and basal ganglia disorders, with an emphasis into the molecular triggers to the disease process, and find that understanding the regulation of mitochondrial pathways may be beneficial in finding pharmacological or non-pharmacological interventions to delay the onset of neurodegenerative diseases.
Journal ArticleDOI
L-kynurenine: Metabolism and mechanism of neuroprotection
TL;DR: This review summarizes the main steps of the kynurenine pathway under normal conditions, discusses the metabolic disturbances and changes in this pathway in certain neurodegenerative disorders, and introduces the therapeutic applications of this pathway.
Journal ArticleDOI
Abnormal Carbohydrate Metabolism in Cerebrospinal Fluid in Rett Syndrome
Toyojiro Matsuishi,Fujiko Urabe,Alan K. Percy,Hironori Komori,Yushiro Yamashita,Rebecca S. Schultz,Yasuyo Ohtani,Norikazu Kuriya,Hirohisa Kato +8 more
TL;DR: Analyzing lactate, pyruvate, α-ketoglutarate, and malate in cerebrospinal fluid by high-performance liquid chromatography suggested that reduced nicotinamide-adenine dinucleotide-ubiquinone oxidoreductase may be deficient in the brain in Rett syndrome patients.
Journal ArticleDOI
Mitochondrial Complex 1, Sigma 1, and Synaptic Vesicle 2A in Early Drug-Naive Parkinson's Disease.
Heather Wilson,Heather Wilson,Gennaro Pagano,Edoardo Rosario de Natale,Edoardo Rosario de Natale,Ayla Mansur,Ayla Mansur,Silvia Paola Caminiti,Sotirios Polychronis,Lefkos T. Middleton,Geraint Price,Karl F. Schmidt,Roger N. Gunn,Roger N. Gunn,Eugenii A. Rabiner,Eugenii A. Rabiner,Marios Politis,Marios Politis +17 more
TL;DR: The objective of this study was to find cross‐sectional and longitudinal changes in PET markers of synaptic vesicle protein 2A, sigma 1 receptor, and mitochondrial complex 1 in drug‐naive PD patients.
Journal ArticleDOI
Metal attenuating therapies in neurodegenerative disease
Alexandra I Mot,Anthony G. Wedd,Layla Sinclair,David R. Brown,Steven J. Collins,Marcus W. Brazier +5 more
TL;DR: In this review, studies spanning a wide variety of neurodegenerative disorders are presented with their involvement of transition metals compared and contrasted, including more detailed treatise in relation to Alzheimer's disease, Parkinson's disease and prion diseases.
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