Journal ArticleDOI
Mitochondrial complex I deficiency in Parkinson's disease.
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This article is published in The Lancet.The article was published on 1989-06-03. It has received 1548 citations till now. The article focuses on the topics: NAD(P)H Dehydrogenase (Quinone) & Substantia nigra.read more
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Journal ArticleDOI
Does Levodopa Accelerate Parkinson’s Disease?
Tanya Simuni,Matthew B. Stern +1 more
TL;DR: Evidence for and against levodopa neurotoxicity and the implications of the ‘levodopa controversy’ on clinical practice are reviewed.
Journal ArticleDOI
Reappraisal of metabolic dysfunction in neurodegeneration: Focus on mitochondrial function and calcium signaling.
TL;DR: In this paper, the authors provide a comprehensive review of the literature and interpret that defective mitochondrial metabolism is upstream and primary to protein aggregation and other dogmatic hypotheses of NDDs.
Journal ArticleDOI
UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress.
Jessica Wing-Man Ho,Philip Wing-Lok Ho,Hui-Fang Liu,Danny Hon Fai So,Koon-Ho Chan,Zero Ho-Man Tse,Michelle Hiu-Wai Kung,David B. Ramsden,Shu-Leong Ho +8 more
TL;DR: Protective effects of c-Rel overexpression in H(2)O(2)-induced oxidative stress were significantly reduced after UCP4 knockdown, indicating that UCP 4 is a target effector gene of the NF-κB c- Rel prosurvival pathway to mitigate the effects of oxidative stress.
Journal ArticleDOI
Association of Glycolysis-Enhancing α-1 Blockers With Risk of Developing Parkinson Disease.
TL;DR: In this article, the authors used active comparator control and propensity score-matched data from Danish nationwide health registries to determine whether use of terazosin, doxaziosin, and alfuzosin is associated with a decreased risk of developing Parkinson disease.
Journal Article
Treatment of parkinson's disease
TL;DR: Dopamine agonists are also helpful and, when taken with low doses of levodopa, often provide sustained benefit with fewer side effects; novel agonists and new methods for their administration are therefore under study.
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