scispace - formally typeset
Journal ArticleDOI

Mitochondrial complex I deficiency in Parkinson's disease.

Reads0
Chats0
About
This article is published in The Lancet.The article was published on 1989-06-03. It has received 1548 citations till now. The article focuses on the topics: NAD(P)H Dehydrogenase (Quinone) & Substantia nigra.

read more

Citations
More filters
Journal ArticleDOI

Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease

TL;DR: Strategies to modulate mitochondrial NO levels will likely be a promising approach to enhance mitochondrial function and protect dopaminergic neurons against oxidative or nitrosative insult.
Journal ArticleDOI

Coenzyme Q10 Depletion in Medical and Neuropsychiatric Disorders: Potential Repercussions and Therapeutic Implications

TL;DR: CoQ10 treatment significantly reduces fatigue and improves ergonomic performance during exercise and thus may have potential in alleviating the exercise intolerance and exhaustion displayed by people with myalgic encepholamyletis/chronic fatigue syndrome.
Journal ArticleDOI

Ursodeoxycholic Acid Ameliorates Apoptotic Cascade in the Rotenone Model of Parkinson’s Disease: Modulation of Mitochondrial Perturbations

TL;DR: UDCA can be introduced as a novel approach for the management of Parkinson’s disease via anti-apoptotic and anti-inflammatory mechanisms that are probably linked to dopamine synthesis and mitochondrial regulation.
Journal ArticleDOI

Maternal transmission of Alzheimer's disease: Prodromal metabolic phenotype and the search for genes

TL;DR: A review of known genetic mutations implicated in EOFAD and their effects on brain chemistry, structure and function; epidemiology and clinical research findings in LOAD, including in vivo imaging findings showing selective patterns of hypometabolism in maternally inherited AD, including chromosome X mutations, mitochondrial DNA and imprinting; and genetic mechanisms involved in other neurological disorders with known or suspected maternal inheritance as discussed by the authors.
Journal ArticleDOI

Natural Antioxidant Anthocyanins—A Hidden Therapeutic Candidate in Metabolic Disorders with Major Focus in Neurodegeneration

TL;DR: It is argued that ROS-targeted therapeutic interventions with naturally occurring antioxidant flavonoid, anthocyanin, and anthochenin-loaded nanoparticles might be the ultimate treatment against devastating illnesses.
Related Papers (5)