Journal ArticleDOI
Mitochondrial complex I deficiency in Parkinson's disease.
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This article is published in The Lancet.The article was published on 1989-06-03. It has received 1548 citations till now. The article focuses on the topics: NAD(P)H Dehydrogenase (Quinone) & Substantia nigra.read more
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Glutathione Deficiency in Gclm Null Mice Results in Complex I Inhibition and Dopamine Depletion following Paraquat Administration
TL;DR: The results suggest that chronic deficiency of GSH in Gclm (-/-) mice was not sufficient to result in complex I inhibition or dopamine depletion perhaps due to homeostatic mechanisms but required an additional oxidative stress insult as shown with paraquat exposure.
Journal ArticleDOI
The Impact of Mitochondrial DNA and Nuclear Genes Related to Mitochondrial Functioning on the Risk of Parkinson’s Disease
TL;DR: Variation in the nuclear genes primarily linked to regulation of mitochondrial functioning that recently have been associated with PD risk are focused on.
Journal ArticleDOI
Emerging drugs for Parkinson's disease.
John C. Morgan,Kapil D. Sethi +1 more
TL;DR: This review discusses emerging drugs in the management of the motor and nonmotor symptoms of PD and drugs under study as disease-slowing/neuroprotective agents.
Journal ArticleDOI
Dimethoxyphenylethylamine and tetrahydropapaverine are toxic to the nigrostriatal system
Isao Koshimura,Hisamasa Imai,Toyoko Hidano,Kiyonori Endo,Hideki Mochizuki,Tomoyoshi Kondo,Yoshikuni Mizuno +6 more
TL;DR: Dimethoxyphenyl-tetrahydroisoquinoline compounds appear to be potent nigral neurotoxins in rats injected with DMPEA and THP, which are potent inhibitors of mitochondrial complex I.
Journal ArticleDOI
Inhibitory effects of antiparkinsonian drugs and caspase inhibitors in a parkinsonian flatworm model.
Yoshihisa Kitamura,Masatoshi Inden,Hisakazu Sanada,Kazuyuki Takata,Takashi Taniguchi,Shun Shimohama,Hidehumi Orii,Makoto Mochii,Kiyokazu Agata,Kenji Watanabe +9 more
TL;DR: The results suggest that the degeneration of planarian dopaminergic system induced by rotenone or MPTP may be mediated through caspase-like activation.
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