Modulation of RNA Condensation by the DEAD-Box Protein eIF4A.
Devin Tauber,Gabriel Tauber,Anthony Khong,Anthony Khong,Briana Van Treeck,Jerry Pelletier,Roy Parker,Roy Parker +7 more
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TLDR
An important role is established for eIF4A, and potentially other DEAD-box proteins, as ATP-dependent RNA chaperones that limit the condensation of RNA, analogous to the function of proteins like HSP70 in combatting protein aggregates.About:
This article is published in Cell.The article was published on 2020-02-06 and is currently open access. It has received 154 citations till now. The article focuses on the topics: RNA & Stress granule.read more
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RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation
Jordina Guillén-Boixet,Andrii Kopach,Alex S. Holehouse,Sina Wittmann,Marcus Jahnel,Marcus Jahnel,Raimund Schlüßler,Kyoohyun Kim,Irmela R.E.A. Trussina,Jie Wang,Daniel Mateju,Ina Poser,Shovamayee Maharana,Martine Ruer-Gruß,Doris Richter,Xiaojie Zhang,Young-Tae Chang,Jochen Guck,Alf Honigmann,Julia Mahamid,Anthony A. Hyman,Rohit V. Pappu,Simon Alberti,Simon Alberti,Titus M. Franzmann +24 more
TL;DR: It is proposed that condensation coupled to conformational rearrangements and heterotypic multivalent interactions may be a general principle underlying RNP granule assembly.
Journal ArticleDOI
Competing Protein-RNA Interaction Networks Control Multiphase Intracellular Organization
David W. Sanders,Nancy Kedersha,Daniel S.W. Lee,Amy R. Strom,Victoria Drake,Joshua A. Riback,Dan Bracha,Jorine M. Eeftens,Allana Iwanicki,Alicia Wang,Ming-Tzo Wei,Gena Whitney,Shawn M. Lyons,Paul A. Anderson,William M. Jacobs,Pavel Ivanov,Clifford P. Brangwynne,Clifford P. Brangwynne +17 more
TL;DR: Inspired by patchy colloid theory, this work proposes a general framework by which competing networks give rise to compositionally specific and tunable condensates, while relative linkage between nodes underlies multiphase organization.
Journal ArticleDOI
Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing.
Simon Alberti,Anthony A. Hyman +1 more
TL;DR: A review of the role of biomolecular condensates in ageing and disease can be found in this paper, where the authors discuss how cellular stress, ageing-related loss of homeostasis and a decline in protein quality control may contribute to the formation of aberrant, disease-causing condensate.
Journal ArticleDOI
LNCcation: lncRNA localization and function.
TL;DR: In this paper, the authors summarize current knowledge of long noncoding RNAs subcellular localization, factors controlling their localization, emerging themes, including the role of lncRNA isoforms and the involvement of LncRNAs in phase separation bodies, and the implications of LNCRNA localization on their function and on cellular behavior.
Journal ArticleDOI
Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates.
Yan G. Zhao,Hong Zhang +1 more
TL;DR: The coordinated actions of membrane-bound and membraneless organelles ensure spatiotemporal control of various cellular functions.
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