Journal ArticleDOI
Multiplexed electrical detection of cancer markers with nanowire sensor arrays.
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TLDR
Highly sensitive, label-free, multiplexed electrical detection of cancer markers using silicon-nanowire field-effect devices in which distinct nanowires and surface receptors are incorporated into arrays opens up substantial possibilities for diagnosis and treatment of cancer and other complex diseases.Abstract:
We describe highly sensitive, label-free, multiplexed electrical detection of cancer markers using silicon-nanowire field-effect devices in which distinct nanowires and surface receptors are incorporated into arrays. Protein markers were routinely detected at femtomolar concentrations with high selectivity, and simultaneous incorporation of control nanowires enabled discrimination against false positives. Nanowire arrays allowed highly selective and sensitive multiplexed detection of prostate specific antigen (PSA), PSA-a1-antichymotrypsin, carcinoembryonic antigen and mucin-1, including detection to at least 0.9 pg/ml in undiluted serum samples. In addition, nucleic acid receptors enabled real-time assays of the binding, activity and small-molecule inhibition of telomerase using unamplified extracts from as few as ten tumor cells. The capability for multiplexed real-time monitoring of protein markers and telomerase activity with high sensitivity and selectivity in clinically relevant samples opens up substantial possibilities for diagnosis and treatment of cancer and other complex diseases.read more
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Risk stratification of heart failure from one drop of blood using hand-held biosensor for BNP detection.
Indu Sarangadharan,Shin Li Wang,Tse Yu Tai,Anil Kumar Pulikkathodi,Chen Pin Hsu,Hui Hua Kenny Chiang,Lawrence Yu Min Liu,Yu-Lin Wang +7 more
TL;DR: A hand-held biosensor system to rapidly screen for brain natriuretic peptide (BNP) from a single drop of whole blood is developed, based on extended gate design of electrical double layer (EDL) field effect transistor (FET), that can directly detect BNP in whole blood, without extensive sample pre-treatments, thereby eliminating the limitations of charge screening in high ionic strength solutions.
Journal ArticleDOI
Doping of Self-Catalyzed Nanowires under the Influence of Droplets
Yunyan Zhang,Zhiyuan Sun,Ana M. Sanchez,Manfred Ramsteiner,Martin Aagesen,Jiang Wu,Dongyoung Kim,Pamela Jurczak,Suguo Huo,Lincoln J. Lauhon,Huiyun Liu +10 more
TL;DR: Be atoms are found for the first time to be incorporated into NWs predominantly through the Ga droplet that is observed to be beneficial for setting up thermodynamic equilibrium at the growth front and causing the growth of phase-pure zincblende NWs.
Journal ArticleDOI
All-printed highly sensitive 2D MoS 2 based multi-reagent immunosensor for smartphone based point-of-care diagnosis
Memoon Sajid,Ahmed Osman,Ahmed Osman,Ghayas Uddin Siddiqui,Hyun Bum Kim,Soo Wan Kim,Jeong Bum Ko,Yoon Kyu Lim,Kyung Hyun Choi +8 more
TL;DR: A general purpose electrical immunosensor has been fabricated for the quantitative detection of multiple bio-reagents through the formation of an antibody-antigen pair and showed promising performance in terms of stability, specificity, repeatability, sensitivity, limit of detection (LoD), and range of Detection (RoD).
Journal ArticleDOI
Stretchable electronic devices using graphene and its hybrid nanostructures
Jihyun Paek,Joohee Kim,Byeong Wan An,Jihun Park,Sangyoon Ji,So Yun Kim,Jiuk Jang,Youngjin Lee,Young Geun Park,Eunjin Cho,Subin Jo,Seoyeong Ju,Woon Hyung Cheong,Jang Ung Park +13 more
TL;DR: In this article, the electrical, optical, thermal, and mechanical properties of graphene and its properties were presented and information concerning the various electronic devices fabricated using graphene and their hybrid materials or structures, with special emphasis on stretchable devices.
Journal ArticleDOI
Noise spectroscopy as an equilibrium analysis tool for highly-sensitive electrical biosensing
TL;DR: In this paper, the authors demonstrate an approach for highly sensitive bio-detection based on silicon nanowire field effect transistors by employing low frequency noise spectroscopy analysis, which is further validated by the detection of cardiac troponin I of 0.23
References
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Journal ArticleDOI
Specific association of human telomerase activity with immortal cells and cancer
Nam Woo Kim,Mieczyslaw A. Piatyszek,Karen R. Prowse,Calvin B. Harley,Michael D. West,Peter L. C. Ho,Gina M. Coviello,Woodring E. Wright,Scott L. Weinrich,Jerry W. Shay +9 more
TL;DR: A highly sensitive assay for measuring telomerase activity was developed in this paper, which showed that telomerases appear to be stringently repressed in normal human somatic tissues but reactivated in cancer, where immortal cells are likely required to maintain tumor growth.
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Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species
TL;DR: The small size and capability of these semiconductor nanowires for sensitive, label-free, real-time detection of a wide range of chemical and biological species could be exploited in array-based screening and in vivo diagnostics.
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In vivo cancer targeting and imaging with semiconductor quantum dots
TL;DR: Sensitive and multicolor fluorescence imaging of cancer cells under in vivo conditions are achieved and a whole-body macro-illumination system with wavelength-resolved spectral imaging is integrated for efficient background removal and precise delineation of weak spectral signatures.
Journal ArticleDOI
Cancer nanotechnology: opportunities and challenges.
TL;DR: Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry that can provide essential breakthroughs in the fight against cancer.
Journal ArticleDOI
The use of nanocrystals in biological detection
TL;DR: The emerging ability to control the patterns of matter on the nanometer length scale can be expected to lead to entirely new types of biological sensors capable of sensing at the single-molecule level in living cells, and capable of parallel integration for detection of multiple signals.