Journal ArticleDOI
Multiplexed electrical detection of cancer markers with nanowire sensor arrays.
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TLDR
Highly sensitive, label-free, multiplexed electrical detection of cancer markers using silicon-nanowire field-effect devices in which distinct nanowires and surface receptors are incorporated into arrays opens up substantial possibilities for diagnosis and treatment of cancer and other complex diseases.Abstract:
We describe highly sensitive, label-free, multiplexed electrical detection of cancer markers using silicon-nanowire field-effect devices in which distinct nanowires and surface receptors are incorporated into arrays. Protein markers were routinely detected at femtomolar concentrations with high selectivity, and simultaneous incorporation of control nanowires enabled discrimination against false positives. Nanowire arrays allowed highly selective and sensitive multiplexed detection of prostate specific antigen (PSA), PSA-a1-antichymotrypsin, carcinoembryonic antigen and mucin-1, including detection to at least 0.9 pg/ml in undiluted serum samples. In addition, nucleic acid receptors enabled real-time assays of the binding, activity and small-molecule inhibition of telomerase using unamplified extracts from as few as ten tumor cells. The capability for multiplexed real-time monitoring of protein markers and telomerase activity with high sensitivity and selectivity in clinically relevant samples opens up substantial possibilities for diagnosis and treatment of cancer and other complex diseases.read more
Citations
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Nanowire transistor arrays for mapping neural circuits in acute brain slices
Quan Qing,Sumon K. Pal,Bozhi Tian,Xiaojie Duan,Brian P. Timko,Tzahi Cohen-Karni,Venkatesh N. Murthy,Charles M. Lieber +7 more
TL;DR: The demonstration of simultaneous high temporal and spatial resolution recording, as well as mapping of functional connectivity, suggest that NWFETs can become a powerful platform for studying neural circuits in the brain.
Journal ArticleDOI
Nanomaterials-based sensors for applications in environmental monitoring
TL;DR: In this article, the authors reviewed recent advances in this direction, by classifying nanomaterials into five categories to illustrate the applications of nanOMaterials in environmental monitoring.
Journal ArticleDOI
Enabling individualized therapy through nanotechnology.
Jason Sakamoto,Anne L. van de Ven,Biana Godin,Elvin Blanco,Rita E. Serda,Alessandro Grattoni,Arturas Ziemys,Ali Bouamrani,Tony Y. Hu,Shivakumar I. Ranganathan,Enrica De Rosa,Jonathan O. Martinez,Christine A. Smid,Christine A. Smid,Rachel M. Buchanan,Rachel M. Buchanan,Sei Young Lee,Sei Young Lee,Srimeenakshi Srinivasan,Matthew Landry,Anne Meyn,Ennio Tasciotti,Xuewu Liu,Paolo Decuzzi,Paolo Decuzzi,Mauro Ferrari,Mauro Ferrari,Mauro Ferrari +27 more
TL;DR: This manuscript provides a forward looking assessment of the promise of nanomedicine as it pertains to individualized medicine and establishes a technology "snapshot" of the current state of nano-based products over a vast array of clinical indications and range of patient specificity.
Journal ArticleDOI
Semiconductor nanowires: A platform for nanoscience and nanotechnology
TL;DR: This review will illustrate concepts using nanowires as a platform material for investigating fundamental properties and performance limits of nanoscale quantum electronic and photovoltaic devices at the single nanowire level.
Journal ArticleDOI
Biosensor technology for detecting biological warfare agents : Recent progress and future trends
TL;DR: In this paper, the authors outline the important issues with regards to the development of biosensors for the monitoring of biological warfare agents (BWAs) starting with the basic components of biosensor and the features of BWAs, which are compatible with detection using biological recognition molecules.
References
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Journal ArticleDOI
Specific association of human telomerase activity with immortal cells and cancer
Nam Woo Kim,Mieczyslaw A. Piatyszek,Karen R. Prowse,Calvin B. Harley,Michael D. West,Peter L. C. Ho,Gina M. Coviello,Woodring E. Wright,Scott L. Weinrich,Jerry W. Shay +9 more
TL;DR: A highly sensitive assay for measuring telomerase activity was developed in this paper, which showed that telomerases appear to be stringently repressed in normal human somatic tissues but reactivated in cancer, where immortal cells are likely required to maintain tumor growth.
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Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species
TL;DR: The small size and capability of these semiconductor nanowires for sensitive, label-free, real-time detection of a wide range of chemical and biological species could be exploited in array-based screening and in vivo diagnostics.
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In vivo cancer targeting and imaging with semiconductor quantum dots
TL;DR: Sensitive and multicolor fluorescence imaging of cancer cells under in vivo conditions are achieved and a whole-body macro-illumination system with wavelength-resolved spectral imaging is integrated for efficient background removal and precise delineation of weak spectral signatures.
Journal ArticleDOI
Cancer nanotechnology: opportunities and challenges.
TL;DR: Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry that can provide essential breakthroughs in the fight against cancer.
Journal ArticleDOI
The use of nanocrystals in biological detection
TL;DR: The emerging ability to control the patterns of matter on the nanometer length scale can be expected to lead to entirely new types of biological sensors capable of sensing at the single-molecule level in living cells, and capable of parallel integration for detection of multiple signals.